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High-risk neuroblastomas exhibit a high degree of intratumoral heterogeneity. Single-cell RNA sequencing has greatly improved our understanding of these tumors, but the method lacks cellular tissue context and spatial information about local signaling dynamics. To address this, we profiled untreated and chemotherapy-treated high-risk neuroblastomas from archived, formalin-fixed, paraffin-embedded
Robots, which were seen as gimmicks in science fiction stories until not so long ago, have already crossed into reality. Thanks to the ever-growing autonomy of robots and ever-expanding variety of roles assigned to them, they are becoming more integrated into the ordinary course of everyday life. With the advent of social robots that can engage human beings on personal levels, for the first time,
An important area of application of robotics technologies is unmanned water surface and underwater vehicles, such as in remote exploration work, maritime transportation, repairs of oil rigs and so on. This study evaluates the consequences of these technologies, particularly in a liability context. Taking into account the characteristics of vehicles mentioned above, especially autonomy, it is expec
För att främja ett aktivt och hälsosamt åldrande (AHA) är det avgörande att förstå hur olika generationer använder digitala teknologier, då dessa verktyg blir en alltmer integrerad del av vardagen. Detta avhandlingsprojekt undersökte teknikanvändning bland kvinnor och män i tre åldersgrupper som representerar olika generationer (30–39, 50–59 och 70–79 år), med fokus på attityder, användningsmönsteTo promote active and healthy ageing (AHA), it is essential to understand how different generations engage with digital technologies, as these tools are becoming increasingly integral to everyday life. This thesis project explored technology adoption among men and women from three age groups representing different generations (30–39, 50–59 and 70–79 years), focusing on attitudes, usage patterns, a
We examine the cross-national comparability of expert placements of political partieson the economic left-right dimension using a novel dataset combining data from Europe, Latin America, Australia, Israel, Canada, and the United States. Using anchoring vignettes and Bayesian Aldrich-McKelvey Scaling (BAM), we assess evidence of geographic and expert-level differential item functioning (DIF) in how
Human-robot interactions are inherently different from interactions with other artefacts, as robots are autonomous. Furthermore, recent technological advances have also enabled robots to undertake roles that are formerly thought to be reserved for humans, e.g. as companions or lovers, since interactive abilities of robots and their autonomy are sufficient to evoke an automatic cognitive response -
This research note introduces the 2024 Chapel Hill Expert Survey (CHES) on party positioning in Europe. When combined with earlier waves of CHES data, this new data set provides estimates of the ideological and policy positions of political parties over twenty-five years of European politics, 1999–2024. The note demonstrates the value of the time series by examining two important trends in Europea
Purpose: This study aimed to investigate the factors associated with blood pressure control in a primary healthcare population with hypertension. Materials and methods: We used baseline data from a recent Swedish randomized controlled trial where 400 patients diagnosed with hypertension from 10 primary health care centers were included. The participants underwent blood pressure measurements, blood
The future role of boreal forests in the global carbon cycle is uncertain given the rapid climate change in high latitudes. At the landscape scale, heterogeneity in stand age and land cover, contributions from terrestrial and aquatic fluxes, and harvest export may create complex carbon cycle-climate interactions. However, the integrated response of the net landscape carbon balance (NLCB) to inter-
BACKGROUND: Prolonged second stage of labor increases the risk of insufficient gas exchange over the placenta to the fetus and risk of birth asphyxia. There are considerable variations in clinical guidelines regarding the recommended duration of pushing during the active second stage of labor. Thus, the aim of this study was to investigate the total duration of the second stage of labor and its as
Hafnia-based ferroelectric Field-Effect Transistors (FeFETs) are promising candidates for non-volatile memory and neuromorphic computing due to their fast switching, low power consumption, and CMOS compatibility [1]–[3]. IIIV materials, such as InAs, offer superior electron transport properties [4], [5], and high remnant polarization at low annealing temperatures when integrated with hafnia-based
Eko was a sound installation made to the art exhibition Öppen visning (May 2025 in Lund, Sweden). The exhibition was set in an apartment for sale and combined the works of several artists. The work uses sounds generated and recorded in the apartment, a 1950’s radio program, and a text borrowed from a visual artwork by Lars Embäck which is also part of the exhibition. The sound installation is acco
Complementary pathways present a legally sound case for an interrogation of the distinction between migration and asylum, as they test the foundations of the international refugee regime and its key principles. Are complementary pathways enhancing the protection of refugees or diluting it? This analysis contributes to a discussion on the intersection between migration and asylum (the “migration-as
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix deposition. Current IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive extracellular matrix production in IPF. Here we show that fibrotic alveolar type II cells regulate producti
BACKGROUND: Bartonella schoenbuchensis is suspected to cause deer ked dermatitis and febrile diseases in humans. Deer keds (Lipoptena cervi), which infest cervids (e.g., roe deer, fallow deer), are discussed as potential vectors for B. schoenbuchensis.METHODS: We analyzed the seroprevalence of anti-B. schoenbuchensis immunoglobulin G (IgG) antibodies in sera of forest workers (FW; n = 82) compared
This study investigated the effects of organic concentration in wastewater on nutrient recovery in a 5-cell electrodialysis (ED) system with sacrificial magnesium (Mg) anode under different current densities and linear flow velocities. Municipal wastewaters without/with dosed alginate were used as feed solutions to simulate diverse organic concentrations. The results revealed that increasing organ
This paper constructs the first long-run estimates of Irish regional GDP over the twentieth century and traces the relative economic performance of Ireland’s regions since independence. Using an array of data sources available at a county level, output in Agriculture, Industry and Services in benchmark census years is estimated. Applying a variety of alternative measures, we find a reduction in re
This special issue examines the role of companies as rights-bearing actors in shaping planetary change. While anthropogenic climate change is commonly framed as the work of humanity, vast disparities in power mean that corporate entities have a disproportionate influence over emissions, political decision-making, and the global flow of biophysical resources. These asymmetries reshape not only clim
