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Introduction In type 2 diabetes (T2D), beta cell failure is often associated with islet inflammation driven by the innate immune response, with macrophages playing a significant role. However, the composition and phenotype of lymphoid immune cells in the islets of individuals with T2D have not been extensively studied. This study aims to characterize and compare the presence, phenotype, and freque
Background: The growing challenges of population aging create a pressing need for specialized geriatric medicine services to effectively address the complex health needs of older adults and influence supportive healthcare policies. Older patients may present clinical complexity with multimorbidity, disability, and/or frailty, necessitating a shift from the traditional organ-oriented clinical appro
Summary: Screening initiatives for osteoporosis must facilitate treatment of those at elevated fracture risk. In a randomized controlled trial of 24,229 women, those in the screening group with FRAX ≥ 15% were invited for DXA with AOM treatment offered as per national guidelines. Treatment initiation in the following year was 9.5 times higher compared with controls. Purpose: To determine if screen
Cyber-Physical Systems (CPS) are integral to critical infrastructure, but their interconnected nature exposes them to sophisticated cyber threats. Traditional security mechanisms primarily focus on detecting direct manipulations of control signals or sensor data, leaving them vulnerable to more subtle attack vectors. This paper introduces a novel optimisation framework for modelling and executing Cyber-Physical Systems (CPS) are integral to critical infrastructure, but their interconnected nature exposes them to sophisticated cyber threats. Traditional security mechanisms primarily focus on detecting direct manipulations of control signals or sensor data, leaving them vulnerable to more subtle attack vectors. This paper introduces a novel optimisation framework for modelling and executing
Background and purpose — In complex primary total knee arthroplasty (TKA), constrained condylar knee (CCK) or rotating hinge knee (RHK) designs may be required to provide stability or address bony deficiencies. We analyzed trends in incidence of these designs in primary TKA and evaluated the mid-to long-term survivorship of CCK and RHK in 4 Nordic countries. Methods — From 2000 to 2017, 5,134 CCK
Evolutionary changes in geographic distribution and larval host plants may promote the rapid diversification of montane insects, but this scenario has been rarely investigated. We studied the rapid radiation of the butterfly genus Colias, which has diversified in mountain ecosystems in Eurasia, Africa, and the Americas. Based on a data set of 150 nuclear protein-coding genetic loci and mitochondri
Context. The peculiar Galactic globular cluster ω Centauri (NGC 5139) has drawn attention for its unique features, such as an unusually high stellar mass compared to other Galactic globular clusters and a broad distribution of chemical elements. These features have led to the hypothesis that ω Centauri might be the nuclear remnant of an ancient dwarf galaxy accreted by the Milky Way, potentially b
High-speed vertical III–V nanowire transistors utilize their channel material for high frequency and low noise performance. A device layout revision to optimize gate resistance, in a trade-off to gate-source capacitance, is presented. A two-step redesign of the established device layout is proposed. First step is demonstrated with fabricated structures. The second step predicts the design transiti
Purpose: People with acquired neurogenic Communication Disorders (PwCD) experience reduced satisfaction in healthcare environments, possibly relating to communication difficulties. Communication Partner Training might improve communication success. The purpose of the scoping review was to map the literature about educational experiences in teaching communication strategies to healthcare students (
Functional gradient sintering of WC-TiC-Co cemented carbides was studied to reveal the effect of powder metallurgical processing conditions on compositional and microstructural, as well as hardness and toughness, gradients. The samples were created by local addition of TiC prior to sintering. Two different starting WC powders, one sub-micron and one medium-coarse, were used. Sintering at two diffe
Measurements of azimuthal angular correlations of inclusive and identified particles from EPOS4 and PYTHIA8 event generators are used to study the unexpected collective behavior observed in small collision systems. In particular, anisotropic flow coefficients measured using two- and four-particle correlations and balance functions are reported in pp collisions at √s = 13.6 TeV. The second-order Fo
The European spruce bark beetle (Ips typographus) is an insect species that causes significant damage to Norway spruce (Picea abies) forests across Europe. Infestation by bark beetles can profoundly impact forest ecosystems, affecting their structure and composition and affecting the carbon cycle and biodiversity, including a decrease in net primary productivity (NPP), a key indicator of forest he
Purpose: To investigate the incidence and risk factors of retinal detachment (RD) and bacterial endophthalmitis in a cohort of children who underwent cataract surgery before the age of eight. Methods: Data was retrieved from the Swedish national paediatric cataract register. All eyes with congenital or infantile cataract that underwent surgery between January 1, 2007, and December 31, 2023 with at
We introduce the concept of cyclicity and hypercyclicity in self-similar groups as an analogue of cyclic and hypercyclic vectors for an operator on a Banach space. We derive a sufficient condition for cyclicity of non-finitary automorphisms in contracting discrete automata groups. In the profinite setting we prove that fractal profinite groups may be regarded as measure-preserving dynamical system
Climate policies are challenged around the world, a development coinciding with the backlash of globalisation. The emergence of the modern welfare state, however, indicates that similar tensions may give rise to transformative change, if coinciding interests for change develop. This article explores the case of Sweden, critical due to its longstanding role as an environmental frontrunner, now expe
Cemented carbides with tungsten carbide grains as hard phase and metallic cobalt binder phase are used extensively for drill bit inserts for rock drilling. The process of rock drilling is severe with some of the wear happening through fracture in the cemented carbide. This work investigated two cemented carbides with iron rich alternative binder phases containing different amounts of FCC phase, in
This study is aimed at detecting Parkinson's disease by analyzing voice measurements made using a mobile phone. The key objectives include creating a model that ensures accurate predictions while maintaining interpretability, consistent with the existing literature on Parkinson's disease. We introduce a novel group-wise scaling method to address typical age and biological sex biases in the dataset
Indoor sensing is challenging because of the multi-bounce effect, spherical wavefront, and spatial nonstationarity (SNS) of the near-field effect. This paper addresses radio-based environment sensing considering these issues. Specifically, graph theory (GT) is used to model the multi-bounce propagation of the near field. In this manner, indoor reflectors/scatterers are modeled as vertices in a pro
