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Purpose To develop an infrastructure for structured and automated collection of interoperable radiation therapy (RT) data into a national clinical quality registry. Materials and methods The present study was initiated in 2012 with the participation of seven of the 15 hospital departments delivering RT in Sweden. A national RT nomenclature and a database for structured unified storage of RT data a

Nutritional management of blood glucose levels is a strategic target in the prevention and management of type 2 diabetes mellitus (T2DM). To implement such an approach, it is essential to understand the effect of food on glycemic regulation and on the underlying metabolic derangements. This comprehensive review summarizes the results from human dietary interventions exploring the impact of dietary

Biblioteks- och informationsvetenskaplig forskning har visat hur infrastruk-turer och data inte är neutrala utan bidrar till att forma både det som de re-presenterar och sammanhangen där de används. Vi utgår från dessa insik-ter och diskuterar i artikeln en nyhetsrapportering från november 2015 som handlade om en eventuell förändring av abortgränsen i Sverige. Registerda-ta från Svenskt Neonatalt Library and information studies research has shown how infrastructures and data are, contrary to common perceptions, not neutral but take part in sha- ping what they represent and the contexts in which they are used. Starting off from these insights we discuss Swedish media reports from November 2015 about a possible alteration of the abortion limit due to recent findings in neonatal care and rese

We investigated phonon-phonon interactions in photoexcited single-crystalline graphite by ultrafast electron diffraction. Transient electron diffraction profiles from a 35 nm graphite film were observed following laser excitation. Changes in intensities of diffraction spots revealed a two-exponential relaxation process with

We report on a theoretical study of the electronic structures of the [1 1 1]-oriented, freestanding, zincblende InAs and InP nanowires with hexagonal cross sections by means of an atomistic sp3s∗, spinorbit interaction included, nearest-neighbor, tight-binding method. The band structures and the band state wave functions of these nanowires are calculated and the symmetry properties of the bands an

People who live in brown bear areas often fear encounters with these animals. This article evaluated the potential effect of exposure to bears and their habitats on human fear of brown bears using the modeling of appropriate behavior when close to bears. In a within-subject design, 25 persons who reported to be fearful of brown bears participated in a guided walk approaching approximately 50 m of

Objective: Iron isomaltoside (Monofer®) is a high-dose intravenous iron preparation with good tolerability and efficacy in inflammatory bowel disease (IBD) patients with iron deficiency anaemia (IDA). This trial evaluates the safety and efficacy, including effect on intact fibroblast growth factor 23 (iFGF23) of a high single dose and cumulative doses of iron isomaltoside in IBD patients with IDA.

Calcium-rich supernovae (SNe) represent a significant challenge for our understanding of the fates of stellar systems. They are less luminous than other SN types and they evolve more rapidly to reveal nebular spectra dominated by strong calcium lines with weak or absent signatures of other intermediate-and iron-group elements, which are seen in other SNe. Strikingly, their explosion sites also mar

Four species of Coleoptera, not previously reported from Sweden are presented; Euconnus campestris (Schaufuss, 1866) (Staphylinidae: Scydmaeninae), Scopaeus ryei Wollaston, 1872 (Staphylinidae: Paederinae), Acritus homoeopaticus Wollaston, 1857 (Histeridae) and Ephistemus reitteri Casey, 1900 (Cryptophagidae). They have all been collected using car net in an area next to the lake Häckeberga in Sca

Background and Purpose - Orosomucoid (α-1-acid glycoprotein) is an acute-phase protein that has been implicated in anti-inflammatory, immunomodulating, and angiogenic pathways. Orosomucoid has also been associated with coronary disease and stroke. The relationship between orosomucoid, carotid plaque, and stroke incidence were explored in this study. Methods - Plasma levels of orosomucoid were asse

Lake Eibsee, Garmisch-Partenkirchen, November 19 to 21, 2015: The European Stroke Organization convened >120 stroke experts from 27 countries to discuss latest results and hot topics in clinical, translational, and basic stroke research. Since its inception in 2011, the European Stroke Science Workshop has become a cornerstone of European Stroke Organization's academic activities and major highlig

BACKGROUND: Globally, the most common method for in situ fixation of slipped capital femoral epiphysis (SCFE) is a threaded screw, which causes physeal arrest. The standard treatment in Sweden is unthreaded fixation using the Hansson hook-pin, which leads to continued growth of the femoral neck. Our purpose was to study remodeling during the remaining growth after fixation with the Hansson hook-pi

Objectives: The Swedish Pulmonary Arterial Hypertension Register (SPAHR) is an open continuous register, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients from 2000 and onwards. We hereby launch the first data from SPAHR, defining baseline characteristics and survival of Swedish PAH and CTEPH patients. Design: Incident PAH and CTEPH

Increasingly the material research deals with is cast as data. This is an ambiguous concept, which describes the matter of research in all stages of the research process. From having been seen as a stepping-stone on the way to producing the scientific results, increasingly data is itself positioned as the result. At the same time demands for data preservation and open data are often motivated with

Importance: Excess alcohol consumption and alcohol use disorders (AUDs) are associated with substantially increased mortality. Efforts to reduce this toll require an understanding of their causes. Objective: To clarify the degree to which the excess mortality associated with AUDs arises (1) from the predispositions of the person who develops AUD (and which would likely be shared by close relatives

Background: Natural killer (NK) cells and NK T cells (NKT) are vital parts of tumour immunosurveillance. However, their impact on prognosis and chemotherapy response in periampullary adenocarcinoma, including pancreatic cancer, has not yet been described. Methods: Immune cell-specific expression of CD56, CD3, CD68 and CD1a was analysed by immunohistochemistry on tissue microarrays with tumours fro

IL-18 has been implicated in inflammatory bowel disease (IBD), however its role in the regulation of intestinal CD4+ T-cell function remains unclear. Here we show that murine intestinal CD4+ T cells express high levels of IL-18Rα and provide evidence that IL-18Rα expression is induced on these cells subsequent to their entry into the intestinal mucosa. Using the CD45RBhi T-cell transfer colitis mo

Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohor

Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or