An expert panel convened by the European Alliance for Personalized Medicine (EAPM) reflected on achievements and outstanding challenges in Europe in mantle cell lymphoma (MCL). Through the prism of member state experience, the panel noted advances in outcomes over the last decade, but highlighted issues constituting barriers to better care. The list notably included availability of newer treatment

As the 2022 human monkeypox (HMPX) multi-country outbreak is spreading, the response of healthcare workers (HCWs) is central to mitigation efforts. The current study aimed to evaluate HMPX knowledge and confidence in diagnosis and management among HCWs in Kuwait. We used a self-administered questionnaire distributed in July–August 2022 through a snowball sampling approach. The survey items evaluat

Given the significance of entrepreneurial women’s contribution to the tourism industry and the fifth UN Sustainable Development Goal (gender equality) this study aims to investigate: first, the interrelationship between women entrepreneurship, creating shared value, and women’s empowerment; and second, the effect of gender-based discriminations on women’s entrepreneurship, creation shared value, a

Background: There are no evidence-based recommendations on the optimal time point to initiate non-vitamin K antagonist oral anticoagulants (NOACs) after acute ischemic stroke in patients with atrial fibrillation. We aimed to investigate the efficacy and safety of early versus delayed initiation of NOAC in these patients. Methods: TIMING (Timing of Oral Anticoagulant Therapy in Acute Ischemic Strok

The present study uses large-eddy simulations (LES) to identify the underlying mechanism that governs the ignition and stabilization mechanisms of ECN Spray A flame for different injection pressures (Pinj) and ambient temperatures (Tam). Two Pinj of 50 MPa and 150 MPa, as well as two Tam of 750 K and 900 K are considered. The numerical model is validated against the experimental fuel penetration,

Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bind with high affinity in the central region of the surface-bound M protein. Suc

Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included a

Agriculture faces risks due to increasing stress from climate change, particularly in semi-arid regions. Lack of understanding of crop water requirement (CWR) and irrigation water requirement (IWR) in a changing climate may result in crop failure and socioeconomic problems that can become detrimental to agriculture-based economies in emerging nations worldwide. Previous research in CWR and IWR has

En aktuell fråga är vilken betydelse det skulle ha för barns rättigheter om barnkonventionen gjordes till svensk lag. Norge, som inkorporerade barnkonventionen i nationell lagstiftning 2003, lyfts ofta fram som ett föregångsland av frivilligorganisationer, men effekten av en inkorporering har inte undersökts närmare i någon vetenskaplig studie. Föreliggande artikel behandlar principen om barnets b

Differential expression of microRNAs (miRNAs) is observed in many diseases including type 2 diabetes (T2D). Insulin secretion from pancreatic beta cells is central for the regulation of blood glucose levels and failure to release enough insulin results in hyperglycemia and T2D. The importance in T2D pathogenesis of single miRNAs in beta cells has been described; however, to get the full picture, h

This is the second component of a two-part paper dealing with a unification of characteristic mode decomposition. This second part addresses modal tracking, interpolation, the role of ohmic losses, and presents several numerical examples for surface-based method-of-moment formulations. A new tracking algorithm based on algebraic properties of the transition matrix is developed, achieving excellent

The 2022 multi-country monkeypox outbreak in humans has brought new public health adversity on top of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The disease has spread to 104 countries throughout six continents of the world, with the highest burden in North America and Europe. The etiologic agent, monkeypox virus (MPXV), has been known since 1959 after isolation from infected monkey

Healthy regeneration of tissue relies on a well-orchestrated release of growth factors. Herein, we show the use of synthetic glycosaminoglycans for controlled binding and release of growth factors to induce a desired cellular response. First, we screened glycosaminoglycans with growth factors of interest to determine kon (association rate constant), koff (dissociation rate constant), and Kd (equil

Aiming to compare capability across persons with impairments using and not using assistive products and persons without impairments in Bangladesh for 16 different functionings, we contrast two sets of self-reported cross-sectional data from eight districts of Bangladesh: (i) data from persons with hearing impairment not using hearing aids, persons with hearing impairment using hearing aids and per

Smac mimetics are a group of compounds able to facilitate cell death in cancer cells. TNF-related apoptosis-inducing ligand (TRAIL) is a death receptor ligand currently explored in combination with Smac mimetics. The molecular mechanisms determining if the combination treatment results in apoptosis are however not fully understood. In this study, we aimed to shed light on these mechanisms in breas

Background: Studies of individuals with non-cancer-related chronic pain, find that higher levels of psychological flexibility (PF) are associated with less distress, better functioning, and a better response to treatment. People diagnosed with cancer are at significantly increased risk of developing chronic cancer-related pain, the presence of which is associated with poorer health outcomes. Littl

A product code with single parity-check component codes can be described via the tools of a multi-kernel polar code, where the rows of the generator matrix are chosen according to the constraints imposed by the product code construction. Following this observation, successive cancellation decoding of such codes is introduced. In particular, the error probability of single parity-check product code

Cancer metabolism is characterized by an increased utilization of fermentable fuels, such as glucose and glutamine, which support cancer cell survival by increasing resistance to both oxidative stress and the inherent immune system in humans. Dialysis has the power to shift the patient from a state dependent on glucose and glutamine to a ketogenic condition (KC) combined with low glutamine levels—

Pulse transformer size is fundamentally linked to application pulselength, pulse power and pulse rise time. In considering long-pulse high-power applications, it has earlier been demonstrated that the large voltage-time integral associated with long-pulse operation in combination with the severe pulse rise time required to ensure high pulse efficiency strictly limits the number of transformer wind