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Rationale: The management of indeterminate pulmonary nodules (IPNs) remains challenging, resulting in invasive procedures and delays in diagnosis and treatment. Strategies to decrease the rate of unnecessary invasive procedures and optimize surveillance regimens are needed. Objectives: To develop and validate a deep learning method to improve the management of IPNs. Methods:ALung Cancer Prediction
The aim of this paper was to analyse how three different television adaptations of Jane Austen’s Emma(1815) avail themselves of the medium of television to narrate the story. The productions analysed are John Glenister’s BBC series from 1972, dramatised by Denis Constanduros; Diarmuid Lawrence’s ITV film from 1996, dramatised by Andrew Davies; and Jim O’Hanlon’s BBC series from 2009, dramatised by
Some major challenges in the development of L2L products is the lack of efficient converter electronics, modelling tools for dimensioning and furthermore, characterization facilities to support the successful development of the products. We report the development of 2 Three-Port-Converters respectively for 1-10Wp and 10-50 Wp with a peak efficiency of 97% at 1.8 W of PV power for the 10 Wp version
BACKGROUND: Intraabdominal and retroperitoneal sarcomas (IaRS) are malignant connective tissue tumors. Surgical resection is often the only curative treatment. The primary objective was to report the mid-term outcomes following contemporary treatment protocols and identify prognostic factors.METHODS: A retrospective review of consecutive patients (n = 107) with IaRS treated at single center from 2
Avhandlingen närmar sig frågan om hur journalistiska praktiker underlättar konstruktionen av kändisstatus. Teoretiskt uppfattas kändisskap som en särskilt flytande form av social status baserat på medierad uppmärksamhet och engagemang. Journalistik studeras som en invitation att dela upplevelser, organiserade utifrån narrativa strukturer. De empiriska fallen som studeras i avhandlingen är två mångThe thesis approaches the research question of how journalistic practices facilitate the construction of celebrity status. Theoretically, celebrity is conceptualised as a particularly fluid form of social status based on mediatized attention and engagement. Journalism is studied as an invitation to shareexperiences, organised through media logics and narrative structures. The empirical cases studi
In-situ quantification of particle concentration during the combustion of solid fuel powders is of importance for analyzing their combustion behaviors. Digital holography (DH) is applied here for studying iron powder combustion at high concentration. The performance of DH as a function of particle concentration is thoroughly studied with synthetic holograms. The detection efficiency is found to be
Residues 136-159 of VPI of foot and mouth disease virus (FMDV) comprise the G-H loop of the protein and form a prominent feature on the surface of virus particles. This sequence contains an immunodominant neutralizing epitope, which can be mimicked with synthetic peptides, and includes an Arg, Gly, Asp motif which has been implicated in the binding of the virus to cellular receptors. Crystallograp
This article addresses the relation between the design of regulatory agencies and efficiency, arguing that authority concentrated to a single individual outperforms more collegial decision-making when the regulated firms’ interests are aligned. The tentative explanation is that concentrated leadership reduces the risk for capture. This argument is developed from an empirical case on the markets fo
Negative trends of climate change and biodiversity loss are closely linked with farming practices, and it is therefore essential to re-think how agricultural systems can sequester more carbon, and simultaneously create vital ecosystems. The overall aim of this research is to imagine Swedish farms as carbon sinks rather than sources, and how to re-design the current farm- and food system to also ad
This chapter explores the use of Experience Sampling Method (ESM) in a qualitative research design, departing from reflections on ontological and epistemological aspects of the tourist experience. It suggests that the tourist experience can be studied in its ordinary moments and proposes the use of ESM to capture such experience of “everydayness”. The chapter illustrates how the method can be used
The dawn of the COVID-19 pandemic in 2020 brought on an acceleration of the transition to virtual spaces in international diplomacy. Studying the virtualization of peace mediation, we describe the new conditions of hybrid peace mediation and show both advantages and challenges in comparison to traditional diplomatic face-to-face meetings. We show how virtual meetings have advantages, such as poten
The paper explores tourists’ smartphone-related information behavior on site in light of the concept of “planned serendipity”. The ability to gatherinformation at anytime and anywhere can deeply influence tourists’ behavior,their information needs and the outcomes of their travel plans. In this study, theconcept of planned serendipity is used to suggest that the outcome of travelinformation behavi
Smartphones have become one of the main tools for travel information search, especially on site, during the trip. The use of mobile technologies and ubiquitous internet connectivity do not only allow tourists to access information anywhere, at any time, but have deep impacts on tourists’ behaviours and on their whole tourist experience.The study suggests an interpretation of tourists’ information
Ribonucleotide reductase (RNR) is an essential enzyme that catalyzes the synthesis of DNA building blocks in virtually all living cells. NrdR, an RNR-specific repressor, controls the transcription of RNR genes and, often, its own, in most bacteria and some archaea. NrdR senses the concentration of nucleotides through its ATP-cone, an evolutionarily mobile domain that also regulates the enzymatic a
SQSTM1/p62 is an autophagic receptor that plays a major role in mediating stress and innate immune responses. Preclinical studies identified p62 as a target of the prototype innate defense regulator (IDR); however, the molecular mechanism of this process remains unclear. Here, we describe the structural basis and biological consequences of the interaction of p62 with the next generation of IDRs, d
