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Objective: To estimate the size of regression to the mean (RTM) for common patient-reported outcomes in trials for knee osteoarthritis (OA). Design: Longitudinal cohort study; we included participants of the Osteoarthritis Initiative who fulfilled typical inclusion criteria for enrolment in a trial. These included: age 40–79 years, symptomatic knee OA, Kellgren-Lawrence grade 2–3, use of pain medi
Distinguishing between vagrancy and regular migration has proved to be challenging as vagrants may, in theory, act as pioneers in the establishment of new migration routes. Because migratory songbirds tend to follow the same orientation and migration route throughout their lives, age assessment can help to distinguish individuals which have already used a route (i.e. adults) from those using it fo
The paper shows, based on a case study of the production of a strategic plan at a fairly traditional university, the problems and potential meaninglessness of working with strategic plans in this type of setting, characterized by strong professional norms. Senior people involved in the strategy work raise strong doubts over, and distancing from, the process and outcome. Possible meanings of the st
Objectives: This study aimed to clinically validate the six-gene prognostic molecular clinical risk score (MCRS) for the prediction of aggressive prostate cancer in diagnostic biopsy tissue. Methods: MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, n = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason
The present study focuses on the computation of interfacial excess potential for the cohesive zones through which a brittle crack propagates in tungsten (W) twist grain boundaries (TGBs). Additionally, the influence of phosphorus (P) impurities is investigated. To this end, we have performed classical atomistic modeling of several ⟨110⟩ TGBs in their pristine and P-impurity segregated states. The
Background: Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regard to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs),
How well patient perceived outcome reflects clinical measurements after arthroscopic lysis and lavage of the temporomandibular joint (TMJ) is not fully understood.The purpose of this study was to detect any correlation between patient reported outcome measures (PROM) and clinical follow-up measurements.Patients with internal derangement of the TMJ treated with arthroscopic lysis and lavage 2014–20
Purpose: Direct percutaneous access to the carotid artery (diPerCa) during endovascular aortic arch repair (EVAAR) can potentially present a minimally invasive access with lesser local adverse events. Techniques: A retrospective review of consecutive EVAAR between January 2018 and January 2024, in a tertiary referral center, was performed to identify cases, in which diPerCa was used. Patients who
This article further theorises and develops the notion of a threat of abandonment while trying to elucidate the applicability and usefulness of this concept in the case of Ukraine in its fight against Russia since 2014. If Ukraine perceives the European Union (EU) as weakened by multiple crises, it may translate this image into a scenario of less attention to Ukraine and its problems, and – ultima
Aims/hypothesis: A better understanding of the mechanisms underlying an elevated infection risk in individuals with type 2 diabetes is needed to guide risk stratification and prevention. We investigated the risk of infection in subgroups of individuals with type 2 diabetes according to indices of insulin sensitivity and beta cell function. Methods: We classified 7265 individuals with recently diag
This article addresses the issue of how Social Science and Humanities (SSH) researchers frame and argue relevance, where there are no explicit expectations to do so. It uses research project reports submitted to a Swedish research council, to distil and further analyze ‘relevance expressions’. These expressions illustrate some methodological differences along the lines of the long-standing distinc
Aim: Public health nurses working in high schools have few set tasks, and there is limited research available on their flexible role. Therefore, the aim of the study was to describe public health nurses’ perspectives on their role when working in Norwegian high schools. Design: A qualitative descriptive design, with an inductive approach. Sample: Eight public health nurses with at least 1-year of
Nonoverlapping domain decomposition methods have been utilized for a long time to solve linear and nonlinear elliptic problems, and more recently, parabolic problems. Despite this, there is no convergence theory for nonlinear elliptic and parabolic equations on general Lipschitz domains in Rd, d ≥ 2. We therefore develop a Steklov–Poincaré theory for nonlinear elliptic and parabolic problems and s
Trust is an important aspect of learning. However, there is little published research on how students perceive its value. In this article, we report on engineering students’ perceptions of the role of trust in their learning and their experiences of what teachers do in their courses that builds trust. Nine students participated in semi-structured interviews and 477 student replies to a survey sent
Background: Cerebrovascular accident (CVA) is an outdated termfor describing stroke as it implies stroke is an accident.We conducted an integrative review to examine the use of CVA in terms of (1) frequency in major medical journals over time; (2) associated publication characteristics (e.g., number of authors, senior author country, topic); and (3) frequency in medical records. Methods: We search
Studies addressing patients’ experiences of person-centered care (PCC) in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are scarce; hence, this study aimed to explore patients’ experiences of PCC, and its associations with individual characteristics and health-related quality of life, in the context of allogeneic stem cell transplantation. It is a cross-sectional su
