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Efficient systemic pharmacological treatment of solid tumors is hampered by inadequate tumor concentration of cytostatics necessitating development of smart local drug delivery systems. To overcome this, we demonstrate that doxorubicin (DOX), a cornerstone drug used for osteosarcoma treatment, shows reversible accretion to hydroxyapatite (HA) of both nano (nHA) and micro (mHA) size. nHA particles
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell
This paper reports on a search for heavy resonances decaying into WW, ZZ or WZ using proton–proton collision data at a centre-of-mass energy of s=13 TeV. The data, corresponding to an integrated luminosity of 139 fb 1, were recorded with the ATLAS detector from 2015 to 2018 at the Large Hadron Collider. The search is performed for final states in which one W or Z boson decays leptonically, and the
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these
A search for the Zγ decay of the Higgs boson, with Z boson decays into pairs of electrons or muons is presented. The analysis uses proton–proton collision data at s = 13 TeV corresponding to an integrated luminosity of 139 fb−1 recorded by the ATLAS detector at the Large Hadron Collider. The observed data are consistent with the expected background with a p-value of 1.3%. An upper limit at 95% con
We report on the measurement of freeze-out radii for pairs of identical-charge pions measured in Pb-Pb collisions at sNN=2.76 TeV as a function of collision centrality and the average transverse momentum of the pair kT. Three-dimensional sizes of the system (femtoscopic radii), as well as direction-averaged one-dimensional radii are extracted. The radii decrease with kT, following a power-law beha
The PHENIX experiment at the Relativistic Heavy Ion Collider has measured φ meson production and its nuclear modification in asymmetric Cu+Au heavy-ion collisions at sNN=200 GeV at both forward Cu-going direction (1.2
Measurements of midrapidity charged-particle multiplicity distributions, dNch/dη, and midrapidity transverse-energy distributions, dET/dη, are presented for a variety of collision systems and energies. Included are distributions for Au+Au collisions at sNN=200, 130, 62.4, 39, 27, 19.6, 14.5, and 7.7 GeV, Cu+Cu collisions at sNN=200 and 62.4 GeV, Cu+Au collisions at sNN=200 GeV, U+U collisions at s
The performance of the ATLAS muon trigger system is evaluated with proton-proton (pp) and heavy-ion (HI) collision data collected in Run 2 during 2015-2018 at the Large Hadron Collider. It is primarily evaluated using events containing a pair of muons from the decay of Z bosons to cover the intermediate momentum range between 26 GeV and 100 GeV. Overall, the efficiency of the single-muon triggers
The pseudorapidity (η) and transverse-momentum (pT) distributions of charged particles produced in proton–proton collisions are measured at the centre-of-mass energy s=13 TeV. The pseudorapidity distribution in |η|<1.8 is reported for inelastic events and for events with at least one charged particle in |η|<1. The pseudorapidity density of charged particles produced in the pseudorapidity region |η
We present measurements of the azimuthal dependence of charged jet production in central and semi-central sNN=2.76 TeV Pb–Pb collisions with respect to the second harmonic event plane, quantified as v2 ch jet. Jet finding is performed employing the anti-kT algorithm with a resolution parameter R=0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy o
The production of the hypertriton nuclei HΛ3 and H[U+203E]Λ-3 has been measured for the first time in Pb-Pb collisions at sNN=2.76 TeV with the ALICE experiment at LHC. The pT-integrated HΛ3 yield in one unity of rapidity, dN/dy×B.R.(HΛ3→He3,π-)=(3.86±0.77(stat.)±0.68(syst.))×10-in the 0-10% most central collisions, is consistent with the predictions from a statistical thermal model using the same
The centrality dependence of the charged-particle pseudorapidity density measured with ALICE in Pb-Pb collisions at √sNN=2.76 TeV over a broad pseudorapidity range is presented. This Letter extends the previous results reported by ALICE to more peripheral collisions. No strong change of the overall shape of charged-particle pseudorapidity density distributions with centrality is observed, and when
Direct photon production at mid-rapidity in Pb–Pb collisions at sNN=2.76 TeV was studied in the transverse momentum range 0.9
Open-Source Software (OSS) is increasingly common in industry software and enables developers to build better applications, at a higher pace, and with better security. These advantages also come with the cost of including vulnerabilities through these third-party libraries. The largest publicly available database of easily machine-readable vulnerabilities is the National Vulnerability Database (NV
The production of electrons from heavy-flavour hadron decays was measured as a function of transverse momentum (pT) in minimum-bias p–Pb collisions at sNN=5.02 TeV using the ALICE detector at the LHC. The measurement covers the pT interval 0.5
A search for dark matter in association with a Higgs boson decaying to two photons is presented. This study is based on data collected with the ATLAS detector, corresponding to an integrated luminosity of 36.1 fb-1 of proton-proton collisions at the LHC at a center-of-mass energy of 13 TeV in 2015 and 2016. No significant excess over the expected background is observed. Upper limits at 95% confide
Experimental results are presented on event-by-event net-proton fluctuation measurements in Pb–Pb collisions at sNN=2.76 TeV, recorded by the ALICE detector at the CERN LHC. These measurements have as their ultimate goal an experimental test of Lattice QCD (LQCD) predictions on second and higher order cumulants of net-baryon distributions to search for critical behavior near the QCD phase boundary
A study of the charge conjugation and parity (CP) properties of the interaction between the Higgs boson and top quarks is presented. Higgs bosons are identified via the diphoton decay channel (H→γγ), and their production in association with a top quark pair (tt¯H) or single top quark (tH) is studied. The analysis uses 139 fb-1 of proton-proton collision data recorded at a center-of-mass energy of
