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Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer’s disease (AD) pathology. However, non-AD-related interindividual variation in biofluids can also affect biomarker concentrations. Here, we investigated whether normalization of CSF and plasma biomarkers to reference proteins, such as amyloid-β40 (Aβ40) and non-phosphorylated mid-re
Objective: Meniscal calcifications are associated with meniscal degeneration and osteoarthritis (OA). We investigated micro-computed tomography (μCT) imaging for identification of calcification patterns caused by basic calcium phosphate (BCP) and calcium pyrophosphate (CPP). Design: Posterior horns of human medial and lateral menisci from 19 individuals with medial compartment knee OA and 21 decea
Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common rheumatic diseases worldwide, causing pain and disability. Both conditions are highly heterogeneous, and their onset occurs insidiously with non-specific symptoms, so they are not always distinguishable from other arthritis during the initial stages. This makes early diagnosis difficult and resource-demanding in clinical env
Background: Expression of CD25, the IL-2 receptor alpha chain, on human mast cells is primarily associated with aberrant mast cells in clonal mast cell disorders. However, the regulation of CD25 expression in normal, mature tissue-resident mast cells remains poorly understood. Objective: IL-33 is a key modulator of immune responses, including in lung inflammatory conditions. Because mast cells are
Abstract Study regionThree mid-high latitude catchments include the Krycklan (Boreal Sweden), the Danube (Central Europe) and the Mississippi (USA).Study focusWe develop a hybrid eco-hydrological framework that couples the process-based terrestrial ecosystem model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) with five machine-learning (ML) algorithms through two hybrid model structure
Mentoring graduate students and postdoctoral researchers shapes the development of future scientists and, by extension, the progress of science itself. Here we explain how scientific mentoring can be enhanced by incorporating history and philosophy of science (HPS). HPS can provide mentees with a vocabulary for interpreting scientific practice and help to foster creative and innovative biologists
OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of therapeutic hypothermia (TH) compared to standard care in newborn infants with hypoxic-ischaemic encephalopathy (HIE).
Preventing obsessive–compulsive disorder (OCD) before it emerges has long been considered a central, yet elusive, goal for researchers. Achieving this will likely require identifying individuals at elevated risk and intervening during critical developmental periods before the onset of impairing symptoms. This trial evaluated the feasibility of a brief parent-guided online targeted prevention progr
This paper critically analyses European Court of Human Rights jurisprudence on bulk data collection, situating it within the Court’s broader turn to proceduralism. We argue that, in cases concerning mass surveillance, the Court has effectively abandoned structured proportionality review and transformed national security from a prima facie legitimate aim into a de facto exception to Article 8. Plac
Background: Children and adolescents with autism spectrum disorder (ASD) are generally more sedentary and engage less in physical activity (PA) than their peers. Despite increasing evidence of benefits, practical guidance on implementing adapted PA programs in real-world settings remains limited. This study aimed to document iterative adaptations, implementation processes, and participant experi
Background: Knowledge is increasing about TSC-Associated Neuropsychiatric Disorders (TAND), but little is known about the potentially confounding effects of intellectual ability (IA) on the rates of TAND across age, sex, and genotype. We evaluated TAND in (a) children vs. adults, (b) males vs. females, and (c) TSC1 vs. TSC2 mutations, after stratification for levels of IA, in a large, internationa
This non-interventional post-authorisation safety study (PASS) assessed the long-term safety of everolimus in patients with tuberous sclerosis complex (TSC) who participated in the TuberOus SClerosis registry to increase disease Awareness (TOSCA) clinical study and received everolimus for the licensed indications in the European Union. The rate of adverse events (AEs), AEs that led to dose adjustm
This article contributes to the literature on sexual harassment at work in China. It advances the theoretical claim that network silences contribute to the persistence of sexual harassment. With the aim of contributing to the understanding of how networksilences are maintained, we analyzed the #MeToo in China Archives 2018–2019. Three themes emerged explaining silences of sexual harassment: (1) th
PURPOSE: To respond to the psychological needs of adolescent and young adult (AYA) cancer survivors, we developed and evaluated a theoretically grounded online intervention to teach adaptive coping skills to promote resilience in early survivorship: 'Recapture Life'. This qualitative study aimed to evaluate the process of implementing Recapture Life into community organisations, after having been
While contemporary scholarship on post-Soviet informality typically frames informal networks as either adaptive (survival) or parallel (subversive forces undermining formal governance) mechanisms, this ethnographic study demonstrates their dual nature as both. Focusing on Uzbekistan’s transitional context (2020–24), the article reveals how informal business networks construct hybrid governance by
Research on degrowth has developed a strong conceptual vocabulary for envisioning alternatives, centered on life-making and collective autonomy within ecological and societal limits. Looking into the past and engaging with anarchism, we argue, can further enrich the degrowth imaginary on transformation beyond the state. A historical approach to political ecology – where delving into the past recla
