Forensic DNA analysis applying PCR enables profiling of minute biological samples. Enhanced analysis conditions can be applied to further push the limit of detection, coming with the risk of visualising artefacts and allele imbalances. We have evaluated the consecutive increase of PCR cycles from 30 to 35 to investigate the limitations of low-template (LT) DNA analysis, applying the short tandem r

Abstract in Romanian ntemeiată la 1348, Universitatea Carolină din Praga se numără printre cele mai vechi instituţii de învăţământ superior din lume. Studiul limbii române beneficiază aici de o bogată tradiţie, acesta fiind introdus la catedra de limbi romanice a Universităţii încă din anul 1882 de către profesorul ceh de filologie Jan Urban Jarník (1848-1923). Este notabil şi faptul că UniversitaFounded in 1348, Charles University in Prague is among the oldest academic institutions in the world. Teaching the Romanian language has a longstanding tradition as well: it was established by the Czech philologist Jan Urban Jarník (1848-1923) within the Romance Department in 1882. Thus Charles University in Prague became the fifth university outside Romania that began teaching Romanian language (

This paper presents an optimization of shell and tube heat exchangers with respect to the total annual costs by a cuckoo search algorithm. The total annual cost is considered as the optimization objective so as to obtain economic heat exchanger structures. The performance of the CSA algorithm is further compared with various algorithm representative of the state of the art in heat exchanger optimi

ABSTRACT Background: Frontotemporal dementia (FTD) constitutes a spectrum of neurodegenerative disorders associated with degeneration of, predominantly, the frontal and temporal lobes. The clinical heterogeneity is evident, and early diagnosis is a challenge. The primary objectives were to characterize psychotic symptoms, initial clinical diagnoses and family history in neuropathologically verifie

Poor insight has a negative impact on the outcome in schizophrenia; consequently, poor insight is a logical target for treatment. However, neither medication nor psychosocial interventions have been demonstrated to improve poor insight. A method originally designed for diabetes patients to improve their illness management, Guided Self-Determination (GSD), has been adapted for use in patients with

We have imaged GaP nanowires (NWs) incubated with human laminin, serum albumin (HSA), and blood plasma using both cryo-transmission electron microscopy and synchrotron based X-ray photoemission electron microscopy. This extensive imaging methodology simultaneously reveals structural, chemical and morphological details of individual nanowires and the adsorbed proteins. We found that the proteins bi

Water soluble acrylic acid grafted luminescent silicon quantum dots (Si-QDs) were prepared by a simplified method. The resulting Si-QDs dissolved in water and showed stable strong luminescence with peaks at 436 and 604 nm. X-ray photoelectron spectroscopy (XPS) was employed to examine the surface electronic states after the synthesis. The co-existence of the Si2p and C1s core levels infers that th

Within linguistics a word class is defi ned in grammatical terms as a set of words that exhibit the same syntactic properties. In this paper the aim is to argue that the meanings of different word classes can be given a cognitive grounding. It is shown that with the aid of conceptual spaces, a geometric analysis can be provided for the major word classes. A universal single-domain thesis is propos

Abstract in Finnish Arvioinnin kohteena oli vuosien 2008–2011 ja 2012–2015 aikana toteutettu pitkäaikaisasunnottomuuden vähentämisohjelmakokonaisuus, Paavo I ja Paavo II. Arvioinnissa keskityttiin ohjelmakokonaisuuteen ja sen eri osa-alueisiin näkökulmana asunto ensin -mallin toteuttaminen suomalaisessa yhteiskunnassa. Arviointiraportissa on kuvattu Iso-Britannian, Ruotsin ja USA:n asunnottomuustyThe review covered the whole of the programme to reduce long-term homelessness implemented during 2008–2011 and 2012–2015, Paavo I and Paavo II. The review focused on the programme as a whole as well as its different aspects from the point of view of implementing the Housing First model in Finnish society. The review report described work on homelessness done in the United Kingdom, Sweden and the

In the present study we have investigated the activity concentrations of (210)Pb, (210)Po as well as (7)Be in surface air of the North and South Atlantic (1988-1989), the Arctic Ocean (1991), and along the coastline of Siberia (1994) during succeeding expeditions in the Swedish Polar Research program. During the cruises in the Arctic Ocean during 1991-07-28 to 1991-10-04 the average air concentrat

Infrared spectra of partially deuterated water trimers have been investigated. It is found that HDO(H(2)O)(2) has a single, bound OD stretching fundamental, (HDO)(2)H(2)O two bound OD stretches. (HDO)(3) has a single, bound OD stretch and (H(2)O)(3) has a pair of bound OH stretches. Ab initio and discrete Fourier transform (DFT) calculations predict that the water trimer has C(1) symmetry with six

With the development of urbanization and deterioration of water environment, the fresh water shortage in eastern coastal cities of China is more and more serious. Desalination, as the only way to increase the amount of fresh water, should be more applied in this region, while the actual development is not as expected for some reasons. The study reviews the desalination status in China from the per

To improve compliance with abdominal aortic aneurysm (AAA) screening in low compliance areas, individually tailored invitations were developed in collaboration with a professional advertising agency. Compliance increased in two intervention municipalities from 71.4% in 2010-2012 to 78.1% in 2013 (p = 0.025), and was then higher [odds ratio 1.7; 95% confidence interval 1.1-2.6; p = 0.013] than in t

Several of the ingredients in fragrance mix I (FM I) have been shown to evaporate from petrolatum preparations applied in test chambers to an extent that can be suspected to affect the patch test result.

IN 2008 AND 2009, the European Commission conducted its Pharmaceutical Sector Inquiry based on a suspicion that a slower rate of approval for new drugs may have resulted from violations of European Union competition law. The Commission issued Preliminary and Final Reports detailing the findings of the Inquiry, which did not include any findings of the sort of competition law violations originally

A finite element plane stress parameter study of the global perpendicular to grain stiffness of timber structural elements such as beams and cross ties is presented. This stiffness is affected by the size and shape of the cross section, the growth ring pattern, the stiffness properties of the wood and the boundary conditions. Various rectangular sections with concentric circular growth rings with

Biomass burning is one of the largest sources of atmospheric trace gases and aerosols globally. These emissions have a major impact on the radiative balance of the atmosphere and on air quality, and are thus of significant scientific and societal interest. Several datasets have been developed that quantify those emissions on a global grid and offered to the atmospheric modelling community. However

Background For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies (inhibitor development). Methods We evaluated 574 consecutive patients with severe hemophilia A (factor VIII activity,