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High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generall
Machine learning (ML) methods have shown noteworthy skill in recognizing environmental patterns. However, presence of weather noise associated with the chaotic characteristics of water cycle components restricts the capability of standalone ML models in the modeling of extreme climate events such as droughts. To tackle the problem, this article suggests two novel hybrid ML models based on combinat
BackgroundWe primarily aimed to determine whether the presence of enlarged cardiophrenic lymph nodes (CPLNs), visualized by computed tomography (CT), and CA-125 can be used to assess diaphragmatic carcinomatosis and residual disease (RD) in advanced ovarian cancer (AOC) patients treated with upfront surgery. The secondary aim was to determine the prognostic role of CT-CPLNs in overall survival (OS
In this paper we explore the potential of academic podcasting to effect positive change within academia and between academia and society. Building on the concept of “epistemic living spaces,” we consider how podcasting can change how we evaluate what is legitimate knowledge and methods for knowledge production, who has access to what privileges and power, the nature of our connections within acade
Combining hard and soft costal protection solutions can be an appropriate measure to enhance structure lifetime. This study aims to quantify the morphological evolution of the nourished stretch and adjacent coastlines. A small-scale beach nourishment has been performed in front of a rock revetment at site in Faxe Ladeplads in Zealand, Denmark. The overall objective is to learn more about the dynam
Personal growth as a process remains vaguely understood. We introduce the Personal Growth Process (PGP) model based on Carl Rogers’s organismic valuing process (OVP). The PGP model explains personal growth as a sociocognitive embodied process whereby an individual undergoes multiple mental shifts that make up an ongoing, fluctuating process over the long term, starting from a place of psychologica
Background and aimsData exploring normal values of different ventricular–arterial coupling (VAC) parameters and their association with anthropometric and cardiovascular (CV) factors are scarce. We aim to report values of two different methods of VAC assessment according to age and sex and explore their association with CV factors within a large population-based cohort of middle-aged individuals.Me
Background:Sensory overresponsivity (SOR) has emerged as a potential endophenotype in obsessive-compulsive disorder (OCD), but few studies have examined SOR in relation to the major symptom dimensions of OCD and to symptoms across the full obsessive-compulsive (OC) symptom spectrum.Objective:This study had 2 main objectives. First, we examined the psychometric properties of the SOR Scales in a com
Cognitive emotion regulation refers to the management of one’s emotions through cognitive strategies. Studies have found that individuals with obsessive–compulsive symptoms utilize emotion regulation strategies differently compared to those without these symptoms. This study aims to investigate the relationship between cognitive strategies for emotion regulation and specific dimensions of obsessiv
BackgroundA machine-learning approach identified five subgroups of diabetes in Europeans which included severe autoimmune diabetes (SAID), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD) with partially distinct genetic aetiologies. We previously validated four of the non-autoimmune subgroup
Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney disease (DKD) in Type 1 diabetes (T1D) with replication in Type 1 and 2 diabetes. Sequencing reproducibly s
Purpose: The majority of women with ovarian cancer are diagnosed in late stages. Most women do have symptoms prior to diagnosis, sometimes several months before the diagnosis. The aim of this study was to evaluate the timeline from the first presentation of symptoms to a physician until there is a reasonable suspicion of cancer, among women diagnosed with advanced stage ovarian cancer. We wanted t
In the ECG recordings during tilt test, changes in RR series characteristics can be observed. The purpose of the present study is to investigate to what extent these changes can be explained by changes in the atrial input and in the atrioventricular (AV) nodal characteristics induced by the autonomic nervous system (ANS). Average RR series characteristics (mean, rmssd and sample entropy) and avera
The frequency of the ECG fibrillatory f-waves (Ff) in atrial fibrillation (AF) shows significant variations over time. Cardiorespiratory interactions through the autonomic nervous system have been suggested to play a role in such variations. Here, we tested whether the spatial distribution associated with the release of the parasympathetic neurotransmitter acetylcholine (ACh) could affect the freq
The heart rate during atrial fibrillation (AF) is highly dependent on the conduction properties of the atrioventricular (AV) node, which can be affected using β-blockers or calcium channel blockers, often chosen empirically. Thus, characterization of the AV nodal conduction properties could contribute to personalized treatment of AF. We have created a mathematical network model of the AV node wher
Hjärntumör inklusive glioblastom.Glioblastom är den vanligaste sortens hjärntumör bland vuxna och samtidigt den mest elakartade. Glioblastom drabbar cirka 550 personer årligen i Sverige. När tumören upptäcks är behandlingen först operation för exakt diagnos och med syfte att avlägsna så mycket som det går av tumören, utan att orsaka skada för patienten, annars görs en diagnostisk biopsi. StandardAbstractBackground: Glioblastoma is the most common malignant brain tumor. Operation with maximal resection, if feasible, otherwise biopsy followed by radiotherapy and chemotherapy with temozolomide is standard therapy. The prognosis remains poor, with median overall survival being 15 months despite therapy. Improved monitoring and treatment response assessment will be important when seeking to im
BACKGROUND: Low birth weight (LBW), advanced glycation end-products (AGE), and ankle-brachial index (ABI) have all been independently associated with risk of cardiovascular disease. Evidence is lacking on the effect of LBW on adult AGE, a marker of glucose metabolism, and ABI, a marker of peripheral atherosclerosis. The objective was to study these associations in a population-based cohort.METHODS
We performed a molecular phylogenetic analysis on the family Euteliidae to clarify deep divergences and elucidate evolutionary relationships at the level of the subfamily, tribe, and genus. Our dataset consists of 6.3 kbp of one mitochondrial and seven nuclear DNA loci and was analysed using model-based phylogenetic methods, that is, maximum likelihood and Bayesian inference. Based on the recovere
