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Background: It remains unknown if bivalirudin compared to heparin confers any additional inhibition of platelet and coagulation activation during primary percutaneous coronary intervention (PPCI) after pretreatment with ticagrelor. Methods: In this substudy of VALIDATE-SWEDEHEART trial, 103 patients pretreated with ticagrelor were randomized before PPCI to heparin or bivalirudin. Blood samples wer
Differential evolution is a real value encoded evolutionary algorithm for global optimization. It has gained popularity due to its simplicity and efficiency. Use of special kind of mutation and crossover operators differentiates it from other evolutionary algorithms. In recent times, it has been widely used in different fields of science and engineering. Among recently developed various variants o
Background: Allergens are foreign proteins that stimulate the production of immunoglobulin E (IgE), when they come in contact with human body. These allergens after binding with IgE through FcεRI receptor, triggers the signal transduction reaction in mast cell and basophil cells, leading to allergic reactions by releasing some mediators. Four correctly written as surface-exposed tryptpphans Trp 87
Objective: Zea m1 is one of the most common aeroallergens, causing allergy. This pollen allergen, present in maize, is responsible for type I hypersensitivity reaction. Despite having available X ray crystal structure of this pollen allergen, no definite vaccine has been developed for allergic disorder in humans. Method: In our present study, an epitope-based peptide vaccine against Zea m 1 pollen
Computer science plays a major role in image segmentation and image processing applications. Despite the computational cost, PSO evaluated QCA approaches perform comparable to or better than their crisp counterparts. This novel approach, proposed in this chapter, has been found to enhance the functionality of the CA rule base and thus enhance the established potentiality of the fuzzy-based segment
Mixed-pixels classification in land-cover regions is a challenging task in remote sensing imagery. To classify mixed-pixels, vagueness is always the main characteristic by handling uncertainty. We propose a hybrid approach for pixel classification using Rough sets and Cellular automata models to solve this problem. Multiple belongingness and vagueness among data can be handled efficiently using Ro
Pixel classification of watershed satellite image is a challenging task in remote sensing. Uses of Particle Swarm Optimisation and Cellular Automata are significant methods in watershed image segmentation. This paper proposes a method of pixel classification using a new hybrid Particle Swarm Optimization-Cellular Automata approach. The proposed unsupervised method identifies clusters using 2-Dimen
Image segmentation among overlapping land cover areas in satellite images is a very crucial task. Detection of belongingness is the important problem for classifying mixed pixels. This paper proposes an approach for pixel classification using a hybrid approach of Fuzzy C-Means and Cellular automata methods. This new unsupervised method is able to detect clusters using 2-Dimensional Cellular Automa
In this paper a novel digital phase lock loop (DPLL) is introduced with Teager energy operator (TEO) incorporated discrete energy separation algorithm DESA2. The output of the DESA2 is controlled using genetic algorithm (GA) optimized fuzzy controller. The input and output membership functions are optimized using GA along with the input and output controller gains of the fuzzy controller. This kin
Image segmentation among overlapping land cover areas in satellite images is a very crucial task. Detection of belongingness is the important problem for classifying mixed pixels. This paper proposes an approach for pixel classification using a hybrid approach of Fuzzy C-Means and Cellular automata methods. This new unsupervised method is able to detect clusters using 2-Dimensional Cellular Automa
Kernel based learning algorithms are sensitive to the choice of appropriate kernel function and parameter setting. Classification accuracies yielded by the kernel based classifiers may show variation depending on the choice of the kernel and its associated parameters. Suggesting an efficient kernel function and effective setting of kernel parameters are thus important problems for kernel based cla
Fuzzy approaches in a low-level image processing method to partition the homogeneous regions are important challenges in image segmentation. The analysis of the fuzziness in data produces comparable or improved solutions compared with the respective crisp approaches. The novel approach proposed in this chapter has been found to enhance the functionality of the fuzzy rule base and thus enhance the
Identification of co-expressed genes is the central goal in microarray gene expression analysis. Point-symmetry-based clustering is an important unsupervised learning technique for recognising symmetrical convex- or nonconvex-shaped clusters. To enable fast clustering of large microarray data, we propose a distributed time-efficient scalable approach for point-symmetrybased K-Means algorithm. A na
Pixel classification among overlapping land cover regions in remote sensing imagery is a very challenging task. Detection of uncertainty and vagueness are always the key features for classifying mixed pixels. This paper proposes an approach for pixel classification using a hybrid approach of rough set theory and particle swarm optimization methods. Rough set theory deals with incompleteness and va
Pixel classification of mixed pixels in overlapping regions of remote sensing images is a very challenging task. Efficiency and detection of uncertainty are always the key ingredients for this task. This paper proposes an approach for pixel classification using Shannon's entropy-based fuzzy distance norm. Unsupervised clustering is used to group the objects based on some similarity or dissimilarit
Identification of cancer pathways is the central goal in the cancer gene expression data analysis. Data mining refers to the process analyzing huge data in order to find useful pattern. Data classification is the process of identifying common properties among a set of objects and grouping them into different classes. A cellular automaton is a discrete, dynamical system with simple uniformly interc
Pixel classification among overlapping land cover regions in remote sensing imagery is a challenging task. Detection of uncertainty and vagueness are always key features for classifying mixed pixels. This chapter proposes an approach for pixel classification using hybrid approach of Fuzzy C-Means and Particle Swarm Optimization methods. This new unsupervised algorithm is able to identify clusters
In rhizosphere Plant Growth Promoting Rhizobacteria (PGPR) produce N-acyl-l-homoserine lactones (AHL) as the quorum-sensing (QS) signals. AHLs can act as trans-kingdom signalling molecules between plants and rhizobacteria and that can regulate plant growth and development. The plant-beneficial PGPR Burkholderia phytofirmans PsJN promotes growth in Arabidopsis thaliana by producing 3-oxo-dodecanoyl
The inference of gene networks from gene expression data is known as "reverse engineering." Elucidating genetic networks from high-throughput microarray data in seed maturation and embryo formation in plants is crucial for storage and production of cereals for human beings. Delayed seed maturation and abnormal embryo formation during storage of cereal crops degrade the quality and quantity of food
A hybrid unsupervised learning algorithm, which is termed as Evolutionary Rough Multi-Objective Optimization (ERMOO) algorithm, is proposed in this chapter. It comprises a judicious integration of the principles of the rough sets theory with the archived multi-objective simulated annealing approach. While the concept of boundary approximations of rough sets in this implementation deals with the in
