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Aspects of proteinase-activated receptor-2: A sensor of enzymatic activity at the cell surface.

Popular Abstract in Swedish Vår kropp består av en till synes oändlig mängd individuella celler. För att alla dessa celler skall kunna fungera som en helhet måste de meddela sig med varandra. För att en cell i tån ska kunna känna av vad som händer i knät så har den bland annat receptorer på sin yta. Receptorer är proteiner som sitter förankrade i cellens yttre skal, i cellmembranet. Receptorns enaInformation about extracellular proteolytic activity is transduced to the cell by a transmembrane G-protein coupled receptor subfamily. These receptors are activated by proteolytic cleavage in the extracellular amino-terminal domain and are thus termed proteinase-activated receptors (PARs). The second member of this subfamily, PAR-2, is activated by trypsin-like proteinases, however the physiologi

Hydro-mechanical properties of a water unsaturated sodium bentonite. Laboratory study and theoretical interpretation

Highly compacted bentonite has been proposed as the buffer material in the Swedish concept for the disposal of nuclear waste. To increase the knowledge of the hydro-mechanical behaviour of unsaturated swelling bentonite a series of laboratory experiments was carried out. The main purpose was to conceptually model the hydro-mechanical behaviour of the bentonite. The influence of testing techniques

Probing single-particle and collective states in atomic nuclei with Coulomb excitation

Popular Abstract in Swedish Atomer är de grundläggande byggstenarna för alla material runt omkring oss. Varje enskild atom består av ett tätt packat område i centrum, som kallas atomkärnan, omgivet av ett moln av elektroner. Atomkärnan innehåller neutroner och protoner, hopbundna av den starka kärnkraften. Vissa kombinationer av neutroner och protoner leder till bildandet av kärnor som är stabilaA series of experiments and developments, related to stable and radioactive isotopes, have been carried out. These studies have focused on measuring the low-lying excitations of spherical and deformed nuclei using electromagnetic (Coulomb) excitation and also on developments in detector technology for upcoming radioactive ion beams facilities. The low-lying excitations in the nuclei 107,109Sn and

Direkt profil: A system for evaluating texts of second language learners of French based on developmental sequences

Direkt Profil is an automatic analyzer oftexts written in French as a second lan-guage. Its objective is to produce an eval-uation of the developmental stage of stu-dents under the form of a grammaticallearner profile. Direkt Profil carries outa sentence analysis based on developmen-tal sequences, i.e. local morphosyntacticphenomena linked to a development in theacquisition of French.The paper pre

Morphological and electromyographical studies of trapezius myalgia in cleaners

Popular Abstract in Swedish Sammanfattning på svenska Avhandlingen är en sammanläggningsavhandling, bestående av fem delarbeten. I avhandlingen studeras yrkesrelaterad muskelvärk (myalgi) i kappmuskeln (trapezius) ur framförallt morfologiska, histopatologiska och elektromyografiska aspekter hos en förhållande stor grupp av försökspersoner. Försökspersonerna består av städerskor med och utan yrkesrPathomechanisms of work-related myalgia are poorly understood. Myalgia is caused by exitation of nociceptors present in the muscular tissue but not in the muscle fibres themselves. Morphological analysis can contribute to knowledge of excitation of nociceptors. Surface EMG is a widely used method in the research field of ergonomics. Knowledge of influence of myalgia, occupation, age and intrinsic

Training Regions Research Centre Strategic Plan 2011-2013

Our world is changing and cities and regions are increasingly understood not only as places, but also as vital hubs in national and global networks, through which people, capital, goods and services flow to ensure the functioning of society, as we know it. People and capital are increasingly concentrated in these hubs, which aside of positive effects on efficiency also is associated with challenge

Curvature Regularization for Curves and Surfaces in a Global Optimization Framework

Length and area regularization are commonplace for inverse problems today. It has however turned out to be much more difficult to incorporate a curvature prior. In this paper we propose several improvements to a recently proposed framework based on global optimization. We identify and solve an issue with extraneous arcs in the original formulation by introducing region consistency constraints. The

The Sun, Space Weather and Effects

The Sun and the solar magnetic activity is responsible for a variety of effects in space and on the Earth. High energy radiation and charged particles are constantly being emitted from the solar atmosphere interacting with our atmosphere and technological systems in space and on the ground. The research papers included in this thesis cover analysis of solar magnetic activity, solar indices, solar