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Acquisition of homozygous activating growth factor receptor mutations might accelerate cancer progression through a simple gene-dosage effect. Internal tandem duplications (ITDs) of FLT3 occur in approximately 25% cases of acute myeloid leukemia and induce ligand-independent constitutive signaling. Homozygous FLT3-ITDs confer an adverse prognosis and are frequently detected at relapse. Using a mou
A search has been performed for photons originating in the decay of a neutral long-lived particle, exploiting the capabilities of the ATLAS electromagnetic calorimeter to make precise measurements of the flight direction of photons, as well as the calorimeter's excellent time resolution. The search has been made in the diphoton plus missing transverse energy final state, using the full data sample
BACKGROUND: Serology for human papillomaviruses (HPV) types -16 and -18 is established as an important tool for studies of HPV vaccinology and epidemiology. However, as there are a large number of oncogenic genital types of HPV there is a need for development of high-throughput, validated HPV serological assays that can be used for more comprehensive seroepidemiological studies and for research on
A concept based on a combination of photofragmentation laser-induced fluorescence (PF-LIF) and two-photon laser-induced fluorescence (LIF) is for the first time demonstrated for simultaneous detection of hydrogen peroxide (H2O2) and water (H2O) vapor. Water detection is based on two-photon excitation by an injection-locked krypton fluoride (KrF) excimer laser (248.28 nm), which induces broadband f
In-situ, time-resolved small-angle neutron scattering (SANS) investigations of the early stages of the spinodal decomposition process in Fe-35Cr were performed at 773 and 798K. The kinetics of the decomposition, both in terms of characteristic distance and peak intensity, followed a power-law behaviour from the start of the heat treatment (a' = 0.10-0.11 and a '' = 0.67-0.86). Furthermore, the met
BACKGROUND: While surgical care impacts a wide variety of diseases and conditions with non-operative and operative services, both preventive and curative, there has been little discussion concerning how surgery might be integrated within the health system of a low and middle-income country (LMIC), nor how strengthening surgical services may improve health systems and population health. METHODS: We
Crystal structure and defects have been shown to have a strong impact on III-V nanowire properties. Recently, it was demonstrated that the issue of random stacking and polytypism in semiconductor nanowires can often be controlled using accessible growth parameters (such as temperature, diameter, and V/III ratio). In addition, it has been shown that crystal phase can be tuned selectively between cu
The anisotropic local electric fluctuations within a nanoscopic sphere of a polar fluid surrounded by vacuum are analysed using dielectric theory and molecular simulation. The electric fluctuations are characterized through the mean-square multipole moments (Q(l)(2)), which are related to the dielectric constant of the fluid. The results show that the fluctuations are suppressed close to the fluid
Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols. In 2008, a MCL international prognostic index (MIPI) was created to enable stratification of the clinical diverse MCL patients into three risk groups. So
Abstract Objectives: The study aimed to test the construct validity, factor structure and reliability of the 11-item version of the Tampa Scale for Kinesiophobia (TSK-11, Swedish version) among older people (65+) with chronic pain. Design: Methodological study. Subjects: 433 participants with chronic pain (mean age 74.8, 65-98 years) completed postal questionnaires. 264 of the participants complet
Haemophilia is a rare disease. To improve knowledge, prospective studies of large numbers of subjects are needed. To establish a large well-documented birth cohort of patients with haemophilia enabling studies on early presentation, side effects and outcome of treatment. Twenty-one haemophilia treatment centres have been collecting data on all children with haemophilia with FVIII/IX levels up to 2
We apply first- and second-order splitting schemes to the differential Riccati equation. Such equations are very important in e.g. linear quadratic regulator (LQR) problems, where they provide a link between the state of the system and the optimal input. The methods can also be extended to generalized Riccati equations, e.g. arising from LQR problems given in implicit form. In contrast to previous
In this paper, we study the minimal problem of estimating the essential matrix between two cameras with constant but unknown focal length and radial distortion. This problem is of both theoretical and practical interest and it has not been solved previously. We have derived a fast and stable polynomial solver based on Gr{\"o}bner basis method. This solver enables simultaneous auto-calibration of f
We describe the setup and first results of an inverse modelling system for atmospheric N2O, based on a four-dimensional variational (4DVAR) technique and the atmospheric transport zoom model TM5. We focus in this study on the European domain, utilizing a comprehensive set of quasi-continuous measurements over Europe, complemented by N2O measurements from the Earth System Research Laboratory of the
We use the strategy method to classify subjects into cooperator types in a large-scale online Public Goods Game and find that free riders spend more time on making their decisions than conditional cooperators and other cooperator types. This result is robust to reversing the framing of the game and is not driven by free riders lacking cognitive ability, confusion, or natural swiftness in respondin
We compared compliance with standards of acute stroke care between 6 European audits and identified factors associated with delivery of appropriate care.
Since the discovery of a formal quintuple bond in Ar'CrCrAr' (CrCr = 1.835 angstrom) by Power and co-workers in 2005, many efforts have been dedicated to isolating dichromium species featuring quintuple-bond character. In the present study we investigate the electronic configuration of several, recently synthesized dichromium species with ligands using nitrogen to coordinate the metal centers. The
In this paper we investigate whether learners of L2 English show knowledge of the Definiteness Effect (Milsark, 1977), which restricts definite expressions from appearing in the existential there-insertion construction. There are cross-linguistic differences in how restrictions on definiteness play out. In English, definite expressions may not occur in either affirmative or negative existentials (
