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Atherosclerosis, the underlying pathology of cardiovascular diseases such as myocardial infarction and ischemic stroke, is characterized by chronic inflammation. T cells are present in atherosclerotic plaques and have been implicated in its pathogenesis. This thesis describes studies exploring both the regulation of T cells in atherosclerosis as well as immunomodulatory therapeutics. To study the
Background: The World Health Organization recommends a minimum of 150 min of moderate intensity exercise per week or 75 min of strenuous activity weekly for adults. Younger hip fracture patients are often assumed less active than the general population, however, knowledge on physical activity (PA) and health-related quality of life (HRQoL) in younger hip fracture patients is limited. Objectives: W
Objective: To explore how cancer survivors have experienced their contacts with primary care after being diagnosed with cancer, focusing on the integration between cancer specialist and primary care, and participants’ views on what could make primary care services better at catering to the needs of cancer survivors. Design: A qualitative study in which data was collected through semi-structured di
Avhandlingen är en studie av hur stöd och service organiseras kring fyra barn med funktionshinder och deras familjer. I denna service är normalt flera olika formella organisationer involverade, som barnhabilitering, förskola/skola/särskola, hjälpmedelscentral, assistentorganisationer, sjukvård m fl. Dessutom kan barnets och familjens situation vara komplicerad på många sätt. Själva funktionshindre
Boreal forests and peatlands store over 30% of the global terrestrial carbon in their vegetation and soil. but changing climate can compromise the current carbon stock. Rising air temperatures, changing precipitation patterns and increased risk of natural disturbances can impact the ability of the boreal ecosystems to absorb and store carbon, reducing their effectiveness as carbon sinks. Reliable
De senaste årens fokus på säkerhetsrisker i samhället har gett upphov till olika former av polisarbete, såsom gränsöverskridande och underrättelsebaserat polisarbete. Den här studien uppmärksammar ett samverkansprojekt mellan gränsmyndigheter i Östersjöområdet som pågick mellan 2014 och 2015. Projektet fick namnet Turnstone och involverade underrättelsepoliser, gränspoliser och kustbevakare från SThe risks and insecurities emphasised in contemporary societies have given rise to diverse forms of policing, such as transnational and intelligence-based police collaborations. This dissertation focuses on a border police collaboration project, called Turnstone, that took place between 2014 and 2015, aiming to address issues related to irregular migration and cross border crimes in the Baltic Sea
Visuals like photographs and videos produced and circulated by lay people in social media serve as significant mediators in crisis communication. Such visuals are crucial for the way contemporary crisis events are defined and perceived in public (Mortensen, 2015; Coombs, 2007). This type of eyewitness footage is a growing visual genre of crisis communication. Yet, previous studies tend to neglect
Childless men are reported to have a higher risk of cardiovascular disease (CVD) and mortality. Information on inherited genetic risk for CVD has improved the predictive models. Presuming that childlessness is a proxy of infertility we aimed to investigate if childless men inherit more often genetic traits for CVD and if combining genetic and parenthood information improves predictive models for C
Background: Saturated fat (SFA) has consistently been shown to increase liver fat, but the response appears variable at the individual level. Phenotypic and genotypic characteristics have been demonstrated to modify the hypercholesterolemic effect of SFA but it is unclear which characteristics that predict liver fat accumulation in response to a hypercaloric diet high in SFA. Objective: To identif
Under de senaste åren har en doktorand ockuperat den akademiska ledningscentralen och skisserat ett antal renoveringar med mål att förändra premisserna för arbetet med breddad rekrytering av studenter från studieovana hem. Utgångpunkten för renoveringarna är att rikta blicken mot de villkor och strukturer, som ’de studieovana’ möter och istället för att fokusera på hur ’De’ ska anpassas till ’Oss’Over the past few years a Ph.D. student has occupied the academic command centre and sketched a number of renovations in order to change the university’s ongoing work to broaden the recruitment of students from homes with no study habit. The point of departure of the renovations is to direct attention to the terms and structures that people with backgrounds different than the academic norm are sup
Background: Galectin 3 and ST2 are mediators and biomarkers of myocardial fibrosis and remodeling that have recently entered the clinical practice guidelines as prognostic factors in heart failure patients. Elevated galectin 3 and ST2 levels in acute myocardial infarction patients have also been associated with increased incidence of adverse events during follow-up. Purpose: We aimed to assess the
Gestational diabetes mellitus(GDM) defines an unhealthy state of hyperglycaemia that develops in response to an otherwise normal physiological adaptive insulin resistance state during pregnancy. However, the exact plasma glucose levels differentiating the unhealthy GDM state from a normal pregnancy is unknown, and relies upon arbitrary cut off criteria based on associations with adverse health out
Background: Stress myocardial perfusion scintigraphy (MPS) is widely regarded as a useful imaging modality for diagnosing patients with suspected ischemic heart disease. Current European guidelines recommend stress study to be performed first since rest study can be omitted if stress study is interpreted as normal. Thus, a rest study should only be performed in patients with equivocal or abnormal
We propose a model to consider data dependencies and assess spatial and temporal variability in land use specific floral coverage across landscapes. Data dependence arising from repeated measurements across the flowering season is taken into account using hierarchical Archimedean copulas, where the correlation is assumed to be stronger within seasonal periods than between periods. For each seasona
Aims: We applied near-infrared-spectroscopy (NIRS) to measure absolute frontal cerebral tissue oxygen saturation (SctO2) during head-up tilt test (HUT) in patients investigated for unexplained syncope.Methods and results: Synchronized non-invasive beat-to-beat haemodynamic monitoring, ECG, SctO2 (NIRS; normal range: 60-80%), and peripheral oxygen saturation (left hand, SpO2) were applied during HU
Objectives: Open abdomen therapy may be necessary to prevent or treat abdominal compartment syndrome (ACS). The aim of the study was to analyse the primary delayed fascial closure (PDFC) rate and complications after open abdomen therapy with vacuum and mesh mediated fascial traction (VACM) after aortic repair and to compare outcomes between those treated with open abdomen after primary versus seco
Background The long-term risk of stroke after surgical treatment of atrial fibrillation is not well known. We performed an observational cohort study with long follow-up after the “cut-and-sew” Cox-maze III procedure (CM-III), including left atrial appendage excision. The aim was to analyze the incidence of stroke/transient ischemic attack (TIA) and the association to preoperative CHA2DS2-VASc (ag
