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Medical students’ access to clinical supervision when rotating through hospital workplaces and the quality of that supervision are and have been an area of growing professional and societal concern. Increased training measures targeted at supervising physicians have been suggested to address this issue. Traditionally, such training has focused on offering physicians opportunities to develop as sup
Aims/hypothesis: Sleep duration is a risk factor for incident diabetes mellitus and CHD. The primary aim of the present study was to investigate, in sex-specific analyses, the role of incident diabetes as the possible biological mechanism for the reported association between short/long sleep duration and incident CHD. Considering that diabetes is a major risk factor for CHD, we hypothesised that a
Popular Abstract in English Every year, Sweden produces 1.5 million tons of incineration residues from waste to energy plants. Among these residues bottom ash(BA) due to its large volume and good geotechnical quality can be reused as an alternative construction material. However there are some negative environmental impacts of this practice such as leaching of salts and metals to soils and groundw
Many parents perceive the urban environment as hazardous for their children and therefore prescribe and circumscribe young people’s access to the environment (Malone, 2001). Consequently, spontaneous unregulated play in neighbourhood spaces is decreasing as children are primarily encouraged to participate in regulated play environments in their homes, friends houses and commercial facilities. Simu
Ambient fine particulate matter PM2.5 (particles with a diameter smaller than 2.5 μm) has been associated with cardiovascular and respiratory morbidity and mortality. It has been shown that biomass burning for heat production purposes can generate large amounts of fine particles. Thus characteristics of particle emissions from biofuel combustion may be important in the assessment of health effects
Since some years ago greenhouse gases and especially carbon dioxide have become one of the most widely debated issues. To reduce the emission of carbon dioxide and nuclear waste, renewable energy sources as for example wind power plants have become very successful. These generation units are normally small compared to common thermal power plants and they are often placed distributed and connected
The chemical industry is primarily dependent on fossil oil and gas as raw materials. With increasing demands on reducing the greenhouse gas emissions and carbon footprint attributed to fossil based production, the industry looks for alternative renewable cleaner resources to secure the supplies for future chemical and material products. The current trend in the shift to bio-based economy aims at u
Importance: Accurate blood-based biomarkers for Alzheimer disease (AD) might improve the diagnostic accuracy in primary care, referrals to memory clinics, and screenings for AD trials. Objective: To examine the accuracy of plasma β-amyloid (Aβ) and tau measured using fully automated assays together with other blood-based biomarkers to detect cerebral Aβ. Design, Setting, and Participants: Two pros
Background Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods For the discovery sample, we did a genome-wide analysis of common genetic variants associated with inc
Bakgrund Med en snabbt växande äldre populationsgrupp kommer även andelen med kognitiva störningar, som demens, att växa. Det är således nödvändigt med forskning på kognition och åldrande. Denna avhandling, genom fyra delarbeten, redogör för testledareffekter vid kognitionsmätningar och hur yngre födelsekohorter (generationer) presterar bättre än äldre på kognitionstester. Den kommer även förklaraGiven a growing population of older adults and the common occurrence of natural as well as pathological cognitive decline, i.e. dementia, there is a need to better understand how to accurately measure and classify level of cognitive functioning. Both using multiple test administrators to collect cognitive data and what year the participant is born (birth cohort effects) can influence participants’
Background High-dose aspirin (>= 500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75-300 mg daily) is unknown. We assessed the effects of aspirin on incidence and mortality due to colorectal cancer in relation to dose, duration of treatment, and site of tumour. Methods
AIMS: Carbohydrate antigen 125 (CA125), a mucin produced by serosal cells in response to mechanical and inflammatory stimuli, has emerged as an important biomarker to guide risk stratification in heart failure (HF). The prognostic value of CA125 in acute coronary syndrome (ACS) patients is less explored.METHODS: In a cohort of 524 ACS patients (73% males, mean age 67 ± 12 years), we assessed the a
IMPORTANCE An accurate prognosis is especially pertinent in mild cognitive impairment (MCI), when individuals experience considerable uncertainty about future progression. OBJECTIVE To evaluate the prognostic value of tau positron emission tomography (PET) to predict clinical progression from MCI to dementia. DESIGN, SETTING, AND PARTICIPANTS This was a multicenter cohort study with external valid
Background: With a trend toward de-escalation of axillary surgery in breast cancer, prediction models incorporating imaging modalities can help reassess the need for surgical axillary staging. Although mammography is routinely performed for breast cancer imaging, its potential in nodal staging remains underutilized. This study aims to employ advancements in deep learning (DL) to comprehensively ev
Stödgrupper för barn som växer upp i familjer med psykisk ohälsa, skadligt bruk/beroende eller våld är en insats som erbjuds av socialtjänsten i många kommuner. Trots att stödgrupper ges på frivilliga grunder utan biståndsprövning, dvs ”lätt tillgängligt” (Prop.2024/25:89), är rekryteringen av barn en utmaning. Denna licentiatuppsats fördjupar kunskapen om de förhållanden och överväganden som påve
