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Importance: Accurate blood-based biomarkers for Alzheimer disease (AD) might improve the diagnostic accuracy in primary care, referrals to memory clinics, and screenings for AD trials. Objective: To examine the accuracy of plasma β-amyloid (Aβ) and tau measured using fully automated assays together with other blood-based biomarkers to detect cerebral Aβ. Design, Setting, and Participants: Two pros
Background Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods For the discovery sample, we did a genome-wide analysis of common genetic variants associated with inc
Bakgrund Med en snabbt växande äldre populationsgrupp kommer även andelen med kognitiva störningar, som demens, att växa. Det är således nödvändigt med forskning på kognition och åldrande. Denna avhandling, genom fyra delarbeten, redogör för testledareffekter vid kognitionsmätningar och hur yngre födelsekohorter (generationer) presterar bättre än äldre på kognitionstester. Den kommer även förklaraGiven a growing population of older adults and the common occurrence of natural as well as pathological cognitive decline, i.e. dementia, there is a need to better understand how to accurately measure and classify level of cognitive functioning. Both using multiple test administrators to collect cognitive data and what year the participant is born (birth cohort effects) can influence participants’
Some seabirds we encounter only fleetingly, as they fly by as we walk along the beach, or perhaps meet far out at sea when we take a boat trip. Others though we are more familiar with, such as the ‘seagulls’ that many will not even turn their head to appreciate. Yet, all seabirds have remarkable stories to tell, and we are fortunate now to live at a time where we can follow individual birds as the
This master thesis was commissioned for the company IAC Group AB in Gothenburg. The factory assembles and delivers instrument panels in sequence to Volvo Car Corporation. The task was to create and implement a maintenance system where all maintenance processes such as preventive maintenance and corrective maintenance can be registered. The purpose was to give the company a deeper knowledge of the
A risk evaluation with regards to fire safety has been performed at Torpa Stenhus. The focus of the evaluation was the safety of the people inside the building in case of a fire. As part of the education for future fire protection engineers at LTH a risk evaluation report is performed in the course Brandteknisk riskvärdering (VBR054). Torpa Stenhus was built during the 15th century and is located
Salinisation is a global issue which leads to desertification and soil degradation and exposure to salt is also known to inhibit microbial activity and plant growth. This study was conducted to determine the influence of salinity on microbial activity of a non- saline soil. By using Salt Induced Community Tolerance (SICT) concept I found that microbial community tolerance to salt can be induced in
It is challenging for the food industry to deliver products that satisfy consumers changing desires and needs. Baobab is a fruit that holds potential for the development of trendy food products due to its rich nutritional profile and unique rheology. Unlike most fruits, it contains a dry pulp with a moisture content of 11-12 % (Phytotrade, 2008). Despite these features, baobab has been overlooked
Mellan Kristianstad och Bromölla finns Ivö, Skånes största ö som i nuläget är okänt utanför närområdet. På öns norra spets reser sig en urbergskulle 134 meter över havet, så kallad Ivö Klack. Området är idag ett naturreservat, med en rik historia av mytologier, torparlämningar, unika fossilfynd, gammal bokskog och industrilämningar från när Ifö-verken, keramikindustrin, utvann sin råvara på ön. IBetween Kristianstad and Bromölla is Ivö, Skåne's largest island, which is currently unknown outside the region. On the northern tip of the island, a primary rock rises 134 meters above sea level, so-called Ivö Klack. The area is today a nature reserve, with a rich history of mythologies, croft remains, unique fossil finds, old beech forest, and industrial remains from when Iföverken, the cera
Vad som händer om någon inte presterar i enlighet med avtalet regleras ofta under rubriken garanti i avtalet. Beroende på hur garantibestämmelsen utformats och på vilket sätt avtalsobjektet avviker från vad som avtalats, kan konsekvensen bli allt från inget ansvar alls, till ett ansvar som innefattar även kompensation för indirekt förlust. Garantiers utformning och omfattning har därför stor ekono
As global concern increases regarding pollution does the demand to develop more ecient and environmental friendlier propulsion system come in high focus. The main systems for transportation have been dominated by the Otto and Diesel engine for a long time, but both are trade-o in local and global emissions, i.e. NOX, soot, HC and CO versus CO2. This has driven the evolution to concepts as homogene
The aim of this Master’s thesis is to evaluate what possible impact an increased use of groundwater may have on the spread of nitrogen pollution. The work is part of a larger project where Sweco Environment AB assists about 40 farmers in the “Köpinge - Vrams vattenförening” to apply for authorization for groundwater use in agricultural irrigation. The work was performed in three steps: a literatur
Decreasing CO2 emissions in the building sector by improving energy efficiency isan essential part of the goal to reduce global CO2 emissions, as the sector accountedfor nearly 40 percent of the energy-related CO2 emissions in 2017.There are six main parameters that affect a building's energy use. These areoutdoor climate, building envelope properties, building services and energysystems, operatio
Background Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D3 inversely associated with T2D, but the epimeric form (C3-epi-25(OH)D3) positively associated with T2D. Whether or not these observational associations are causal remains uncertain. We aimed to examine the potential causality of thes
