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Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) provides a mechanistic basis for impairment in glycaemic control through the interactions of substrate availability, substrate metabolism and abdominal ectopic fa
BACKGROUND: Overweight and gestational diabetes are risk factors for pregnancy complications. We hypothesized that the metabolic impact of overweight on pregnancy outcome, would be different if it was combined with a predisposition for diabetes. The aim of this study was to compare the outcome of pregnancies in women with diabetes diagnosed later in life, to the outcome of pregnancies of women who
Background: Semi-natural pastures are unfertilized grasslands with a long history of traditional low-input grazing management. This kind of pastures are recognized for their high species richness. However, as a consequence of modernization of agriculture, many of the semi-natural pastures have been lost during the last century, leading to a serious threat to farmland biodiversity. Semi-natural pas
Stress factors such as climate change and drought may switch the role of temperate peatlands from carbon dioxide (CO2) sinks to sources, leading to positive feedback to global climate change. Water level management has been regarded as an important climate change mitigation strategy as it can sustain the natural net CO2 sink function of a peatland. Little is known about how resilient peatlands are
A significant part of our cultural heritage consists of wood. Research on historical wooden structures and artefacts thereby provides knowledge of people’s daily lives and the society in which they lived. Dendrochronology is a well-established dating method of wood that can also provide valuable knowledge about climate dynamics, environmental changes, silviculture, and cultural transformations. HoA significant part of our cultural heritage consists of wood. Research on historical wooden structures and artefacts thereby provides knowledge of people’s daily lives and the society in which they lived. Dendrochronology is a well-established dating method of wood that can also provide valuable knowledge about climate dynamics, environmental changes, silviculture, and cultural transformations. Ho
Background: Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer. The current study aimed to elucidate the molecular mechanism underlying the effect of CSMD1 in highly invasive triple negative breast cancer (TNBC). Methods: We examined the antitumor action of CSMD1 in three TNBC cell lines overexpressing CSMD1, MDA-MB-231, BT-20 and MDA-MB-486,
The 3.1- and 3.7-km-deep FFC-1 and DGE-1 geothermal explorations wells drilled into the Precambrian crystalline basement on the southern margin of the Fennoscandian Shield are evaluated regarding experiences from drilling, geological conditions, and thermal properties. Both wells penetrate an approximately 2-km-thick succession of sedimentary strata before entering the crystalline basement, domina
Background: Carotid atherosclerotic plaques with intraplaque hemorrhage (IPH) are associated with elevated stroke risk. IPH is predominantly imaged based on paramagnetic properties of the upstream hemoglobin degradation product methemoglobin. This is an explorative observational study to test the feasibility of a spoiled gradient echo based T2* weighted MRI sequence (3D MEDIC) for carotid plaque i
Water contamination with per- and polyfluoroalkyl substances (PFAS) is a serious problem for water suppliers in many regions. Due to persistence of the substances and a complex distribution mechanism, PFAS can have an adverse impact on water quality. Reported toxicological and health effects, make it very important to minimise the of wildlife and human exposure to PFAS. The exposure path is, howev
Sphingosine 1-phosphate (S1P) has pleiotropic biological functions in the regulation of proliferation, survival, migration, inflammation or angiogenesis. S1P acts as intracellular second messenger, as well as extracellular receptor ligand via five G-protein coupled receptors (S1PR1-5). In the brain, S1P regulates neuronal proliferation or apoptosis, excitatory neurotransmission and neuroglia activ
Obesity associates with reduced life expectancy, type 2 diabetes, hypertension and cardiovascular disease, and is characterized by chronic inflammation. Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein, dead cells and some microorganisms. Antibodies against PC (anti-PC) have anti-inflammatory properties. Here, we explored the role of anti-PC in hospitalized versus non-hospi
Objective: Medical crises occur rather seldom in the primary care setting, but when they do, initial management impacts on morbidity and mortality. Factors that impede the performance of emergency interventions in primary care have not been studied through in-situ simulation. Checklists reportedly improve crisis management. Design: This randomized controlled trial evaluated emergency intervention
OBJECTIVE Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting in anti-AGE-specific autoantibodies. The association of these immune responses with macro- and microvascular complications in type 1 diabetes remains unclarified. We investigated associations between MGO-modified apolipoprotein B
OBJECTIVES: Preterm birth has been linked with increased risk of autism spectrum disorder (ASD); however, potential causality, sex-specific differences, and association with early term birth are unclear. We examined whether preterm and early term birth are associated with ASD in a large population-based cohort. METHODS: A national cohort study was conducted of all 4 061 795 singleton infants born
PURPOSE: Intrauterine undernutrition is associated with increased risk of type 2 diabetes. Children born premature or small for gestational age were reported to have abnormal retinal vascularization. However, whether intrauterine famine act as a trigger for diabetes complications, including retinopathy, is unknown. The aim of the current study was to evaluate long-term effects of perinatal famine
An increased prevalence of obstructive sleep apnoea (OSA) has been suggested in patients with ankylosing spondylitis (AS) in a few controlled studies. We aimed to study the prevalence of OSA compared to controls and to investigate if disease-related and non-disease-related factors were determinants of OSA in AS patients. One hundred and fifty-five patients with AS were included in the Backbone stu
Wild bees are declining in many parts of the world, which poses a risk for crop pollination and ecosystem health. Land use and climate change are two of the main drivers of the decline, and understanding the interactive effects of these two drivers and wild bees is very important to be able to develop proper responses and mitigate future negative effects. In this thesis I have investigated the ef
BACKGROUND: The association between leisure-time physical activity and cardiovascular mortality has been previously studied, but few studies have focused on specific activities and intensities.METHODS: The association between different leisure-time physical activities and cardiovascular mortality was investigated among 25,876 individuals without diabetes or cardiovascular disease from the populati
