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OBJECTIVE Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise beta-cell function in a Phase II clinical trial. GADA affinity has been shown

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Med avseende på de svenska förhållandena vintertid kan frostpåverkan antas ha betydande inverkan på nedbrytningen av betong i vattenbyggnader. Både ytliga och inre skador, vilka misstänks ha orsakats av frostpåverkan, har upptäckts på betong i exempelvis vattenkraftkonstruktioner. Nämnda observationer har väckt frågor om vattenbyggnaders beständighet i ett kallt klimat. Ytligt belägna skador, vil

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In response to the increased early workflow implied by BIM processes it is important for design consultants to focus on creating and communicating information that is critical for its purpose (Jernigan 2008) - be it model content for 3d Design Coordination at scheme design stage, or Cost Estimation at Design Development stage, or generation of a suitable Record Model for Facilities Management. Tod

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Popular Abstract in English Darwin’s masterpiece “On the origin of species” describes how populations (one group of individuals from the same species that can easily mate with each other and that occupy the same geographic area) evolve through the process of natural selection, which can be shortly abbreviated as the survival of the fittest. More specifically, the individuals within one population The gene (Pgi) encoding the enzyme phosphoglucose isomerase (PGI) which plays a central role in the main pathways of carbon metabolism has been shown to be of adaptive significance in a wide range of different species. Earlier studies of enzyme electromorph variation in the grass Festuca ovina suggest that variation in cytosolic PGI (PGIC) may be involved in the adaptive response of F. ovina to th

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Extracellular glutathione peroxidase (eGSHPx) is a selenoprotein catalysing the reduction of hydrogen peroxide, organic peroxides and lipid peroxides in the presence of glutathione. A scaled-up purification procedure for obtaining eGSHPx from human plasma was established based on ammonium sulphate fractionation, hydrophobic interaction chromatography, ion-exchange chromatography and gel chromatogr

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I denna bok utforskas den rättsliga hanteringen av duellbrott som ärekränkningar och dueller med dödlig utgång under stormaktsväldets slutskede. Med inspiration från New Cultural History och teorier om manlighet och våld analyseras lagtexter, rättsfall, prästers och rättslärdas skrifter samt anklagade duellanters brev och nådeansökningar. Studien fokuserar på hur den rättsliga diskursen kring duel

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What are the social positions of adults who were in long-term foster care as children, compared with the general population and with adults who grew up at home in families similar to foster children's birth families? How common is it to have been in foster care? Four approaches are used in this study: - A systematic review of around 50 studies on adult foster children. Conclusions are more pessim

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BACKGROUND: Short body height is associated with increased risk for coronary heart disease; however, mechanisms are not fully explained. In this study, associations between body height and serum cholesterol, non-high-density lipoprotein (non-HDL cholesterol) and high-density lipoprotein (HDL cholesterol) were investigated. METHODS: Prospective cohort study of middle-aged men from Helsingborg, Swed

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1. In intensively farmed agricultural landscapes, many species are confined to very small uncultivated areas such as field margins. However, it has been suggested that these small habitat elements cannot support viable populations of all the species observed there. Instead, species richness and abundance in these small habitat fragments may, at least partly, be dependent on dispersal from larger s

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The hallmark of severe haemophilia, defined as a circulating level of factor (F) VIII (haemophilia A cases) or FIX (haemophilia B cases) of < 1%, is recurrent bleeding into muscles and joints (haemarthroses) from an early age of life. The inevitable result of such bleeding is progressive joint damage, leading to disabling arthritis that is typically evident within the first 2 decades of life in pe

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The primary productivity of a plant community can be modeled as the product of the amount of photosynthetically active radiation (PAR) absorbed by the canopy and a light use efficiency factor, where the amount of absorbed PAR (APAR) is the product of the fractional absorption and the amount of incident PAR. By implementing a method, PARcalc, using atmospheric data from the Moderate Resolution Imag

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Background: Smoking and the use of smokeless tobacco have a detrimental impact on general and oral health. The relationship to dental caries is however still unclear. As caries is a multi-factorial disease with clear life-style, socio-economic and socio-demographic gradients, the tobacco use may be a co-variable in this complex rather than a direct etiological factor. Our aim was to analyze the im