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People with intellectual disabilities have an increased risk of diabetes mellitus (DM). They tend to develop it at earlier ages than the general population, resulting in even higher risks in younger people. However, few studies have separated Type 1 and Type 2 DM. The aim of this study was to assess prevalence of different types of DM in different age groups in relation to the general population.

Background: Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to understand the influence of metformin on the levels of the circulating proteome. Methods: We analysed a combined longitudinal proteomics dataset from the IMPOCT, RAMP and S3WP-T2D clinical trials in 98 participants before and after metformin e

BACKGROUND: n-3 (ω-3) long-chain polyunsaturated fatty acids (n-3 LCPUFAs) have anti-inflammatory effects that may influence immune-mediated diseases.OBJECTIVES: We investigated whether higher maternal pregnancy intake of n-3 LCPUFA is associated with a lower incidence of infection in young children.METHODS: We used data from 3 Nordic cohorts: the Norwegian Mother, Father and Child Cohort study (M

Objective To delineate organ-specific and systemic drivers of metabolic dysfunction-associated steatotic liver disease (MASLD), we applied integrative causal inference across clinical, imaging, and proteomic domains in individuals with and without type 2 diabetes (T2D). Methods Bayesian network analyses and complementary two-sample Mendelian randomization were used to quantify causal pathways link

BACKGROUND: Several studies have sought to investigate gambling craving and its potential contribution to gambling problems. One aim of this line of research has been to further examine whether craving should be considered a separate diagnostic criterion for gambling disorder, which it currently is not. The present study aimed to investigate the relationship between craving and other risk factors—

Background: Heart diseases are among the leading causes of disease burden worldwide with often a large impact on the lives of the affected individuals. The association between heart disease and depression is well-known and elevated suicide risk has been demonstrated in several types of heart disease. The aim of this study was to investigate what health care contacts individuals with heart disease

Taurine, an amino sulfonic acid abundant in seafood and meat, has been proposed to have a potential role in the prevention of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its antioxidant and anti-inflammatory properties. However, the association between dietary taurine intake and MASLD remains unclear in human populations. Also, data on dietary taurine intake among adult

Populärvetenskaplig sammanfattning: Kvävebelastningen på sjöar och hav har ökat markant de senaste tiotal åren. Jordbruket står för ca 50 % av de svenska kväveutsläppen som människan bidrar till. En ökad kvävebelastning på haven kan leda till övergödning, vilket får en stor negativ effekt på vattenekosystemen. Ett sätt att minska övergödningsproblematiken är att öka vattnets uppehållstid i landskaPolitical decisions have resulted in more focus on how to optimize wetlands natural ability to lower nitrogen fluxes in order to minimize the problem with eutrophication in costal areas. However there is no exact knowledge how to calculate the effectiveness of nitrogen removal in wetlands with natural water flow due to the many biochemical and hydrological processes that interact. In this study tw

Populärvetenskaplig sammanfattning: Den ökande växthuseffekten, med påföljande klimatförändringar, framträder alltmer som ett av vår tids största miljöproblem. På grund av människans industriella och agrikulturella aktiviteter har atmosfärskoncentrationen av de viktiga växthusgaserna koldioxid (CO2), metan (CH4) och lustgas (N2O) ökat drastiskt. Med hjälp av modeller och beräkningar förutspås det Northern peatlands are important in the context of the climate change. Since they comprise huge amounts of soil organic carbon and are found where the most significant greenhouse warming is predicted, they have the potential to exert major feedback effects on the global warming. Studies of the greenhouse gas exchange in northern peatlands have mainly focused on the growing season when the soil is

Populärvetenskaplig sammanfattning: Jordens klimat är ett aktuellt forskningsämne. För att komma fram till resultat som är globalt applicerbara bedrivs forskning för att öka förståelsen och kunskapen om återkopplingsmekanismer mellan klimat och vegetation på många platser runt om i värden och i olika klimatzoner. Sedan början av 1900-talet har det pågått forskningsstudier (av ekosystemprocesser) iThis report investigates the utilization of digital camera images (DCIs), sensitive in the visible part of the spectrum, for documentation of seasonal and inter-annual variations in snow cover and plant phenology. The DCIs used were transformed to orthographic images (ortho-image) from ordinary oblique DCIs taken between January 2001 and December 2003 at a sub- arctic mire (Stordalen) in northern

In modern cancer therapy, radiotherapy (RT) is a vital part of most treatments. Most RT treatments in Sweden are performed using intensity-modulated radiotherapy (IMRT) with fixed or dynamic arc delivery. The dose gradients outside the target are steep, the margins are small, and the treatment delivery is complicated. Complicated treatments increase the requirement for control of the uncertainties

Background: Parkinson's disease (PD) is a progressive neurodegenerative disease with motor- and non-motor symptoms. When the disease progresses, symptom burden increases. Consequently, additional care demands develop, the complexity of treatment increases, and the patient's quality of life is progressively threatened. To address these challenges, there is growing awareness of the potential benefit

Increasing land-use intensity is a main driver of biodiversity loss in farmland, but measuring proxies for land-use intensity across entire landscapes is challenging. Here, we develop a novel method for the assessment of the impact of land-use intensity on biodiversity in agricultural landscapes using remote sensing parameters derived from the Sentinel-2 satellites. We link crop phenology and prod

Poster A153Introduction: Diabetic peripheral neuropathy (DPN) is a devastating complication to DM, potentially leading to diabetic foot ulcers. Studies using electrophysiology shows high occurrence of subclinical DPN among children, but it is unclear when and how to start screen children with T1D for DPN. Aim: To investigate whether evaluation of the vibrotactile sense, using a multi-frequency method, in the

Introduction: Decline in physical function varies substantially across older individuals due to several extrinsic modifiable factors such as dietary patterns, physical activity and social support. We aimed to determine the association of these factors and their interaction with mobility and muscle strength decline. Methods: We analyzed data from 1686 functionally healthy individuals aged 60 + from

BACKGROUND: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink a