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Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedis

Aim: It has been claimed that supraspinal structures are necessary forthe depression of nocifensive behaviour elicited by acupuncture or acupuncturelike (AL) stimulation. However, nocifensive reflexes in the spinal catwere inhibited for long periods by a mechanism releasing opieids on AL conditioning stimulation of groups II-III muscle afferents (Sj~lund and Eriksson, Neurosci.Lett. S3:264:1979).

Background:Nurses and physicians in nephrology settings provide care for patients with end-stage kidney disease receiving hemodialysis treatment along a complex illness trajectory.Aim:The aim was to explore physicians’ and nurses’ perspectives on the trajectories toward the end of life involving decisions regarding hemodialysis withdrawal for patients with end-stage kidney disease.Research design

Background: Smoking is a strong risk factor for the development of Graves’ ophthalmopathy (GO). Immediate early genes (IEGs) are overexpressed in patients with active GO compared to healthy controls. The aim of this study was to study the effects of tobacco smoking and simvastatin on preadipocytes and orbital fibroblasts (OFs) in the adipogenic process. Methods: Cigarette smoke extract (CSE) was g

Background.The role of schools in providing community-based support for children's mental health and well-being is widely accepted and encouraged. Research has mainly focused on designing and evaluating specific interventions and there is little data available regarding what provision is available, the focus and priorities of schools and the professionals involved in providing this support. The cu

BACKGROUND: Exposure to moldy or damp indoor environments is associated with allergic disease in young children, but it is unclear whether the effects persist to adolescence. Our objective was to assess whether exposure to mold or dampness during infancy increases the risk of asthma, rhinitis, or IgE sensitization in children followed from birth to 16 years of age.METHODS: We collected questionnai

The impact of Parkinson's disease (PD) on workforce participation has received little attention even though demographic, lifestyle, and political changes together will result in an increased burden of PD on the working-age population. In this study, we investigate workforce survival after a PD diagnosis, as well as what demographic factors that are associated with workforce survival. As an explora

Objective Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population heterogeneity is not described by measurement of total haemoglobin or haematocrit. We therefore aimed to describe a subpopulation of large RBCs with hyper high

BACKGROUND: Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated.METHODS: We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spac

Geological time is by many geoscience instructors considered a threshold concept for geoscience students, being a central concept for how we experience geosceince phenomena that takes place on a spatio-temporal scale ranging from micro (e.g. cloud formation) to macro (e.g. plate tectonics). If one wishes to understand geoscience phenomena that goes beyond human perception, one must move from the cGeological time is by many geoscience instructors considered a threshold concept for geoscience students, being acentral concept for how we experience geosceince phenomena that takes place on a spatio-temporal scale rangingfrom micro (e.g. cloud formation) to macro (e.g. plate tectonics). If one wishes to understand geoscience phenomenathat goes beyond human perception, one must move from the conc

Chimney sweeps have higher incidence and mortality of cardiovascular disease (CVD), likely related to their exposure to polycyclic aromatic hydrocarbons (PAH). In order to identify underlying mechanisms of PAH-related CVD, we here investigated whether PAH exposure was associated with levels of putative CVD-related proteins in serum among currently working chimney sweeps. We enrolled 116 chimney sw

Icke-förskriven användning av opioidläkemedel, såsom tramadol, är ett stort globalt hälsoproblem. I Sverige har användningen av tramadol bland unga uppmärksammats stort och lyfts fram som ett nytt droganvändningsmönster. Det övergripande syftet med denna licentiatuppsats är att utforska droganvändningsförlopp och processen att försöka sluta med droger bland unga med erfarenhet av problematiskt tra

BackgroundOlder adults have a high prevalence of chronic pain, which can have a substantial effect on their health and quality of life. Patients’ use of effective pain relief methods is a central part of the treatment and management of chronic pain. The utilization of pain relief methods and their perceived effectiveness are important knowledge for treating and managing chronic pain for clinicians

RNA binding motif protein X‐linked (RBMX) encodes the heterogeneous nuclear ribonucleoprotein G (hnRNP G) that regulates splicing, sister chromatid cohesion and genome stability. RBMX knock down experiments in various model organisms highlight the gene’s importance for brain development. Deletion of the RGG/RG motif in hnRNP G has previously been associated with Shashi syndrome, however involvemen

To optimize the workflow of civil engineering construction in a harbour, this paper developed a framework of the contaminant leaching assessment carried out on the stabilized/solidified dredged soil material. The specimens included the sampled sediments collected from the in situ fieldwork in Arendal and Kongshavn. The background levels of the concentration of pollutants were evaluated to assess t