Search results

Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigat

Background: In many parts of the world, roadsides are regularly managed for traffic-safety reasons. Hence, there are similarities between roadsides and certain other managed habitats, such as wooded pastures and mown or grazed grasslands. In contrast to roadsides, the latter habitats have declined rapidly in Europe during the last century, and today only a fraction of their former extent remains.

Introduction: The aim of this study is to report the current status of ovarian tissue cryopreservation among alternatives for fertility preservation in the Nordic countries. Material and methods: A questionnaire was sent to 14 Nordic academic reproductive centers with established fertility preservation programs. It covered fertility preservation cases performed up to December 2014, standard proced

Background-The correlation of null alleles with human phenotypes can provide insight into gene function in humans. In individuals of African ancestry, we set out to identify null and damaging missense variants, and test these variants for association with a range of cardiovascular phenotypes. Methods and Results-We performed whole-exome sequencing in 3223 black individuals from the Jackson Heart S

Background: Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D. Methods: Renin was analyzed by the Proximity Extension Assay in subject

Background: Associations between BMI and DNA methylation of hypoxia-inducible factor 3-alpha (HIF3A) in both blood cells and subcutaneous adipose tissue (SAT) have been reported. In this study, we investigated associations between BMI and HIF3A DNA methylation in the blood and SAT from the same individuals, and whether HIF3A gene expression in SAT and skeletal muscle biopsies showed associations w

BACKGROUND: A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the ratio between somatic and germline BRCA1/2 mutations in unselected breast cancer patients are currently unclear.PATIENTS AND METHODS: Paired normal and tumor DNA was analyzed for BRCA1/2 mutations by massively parallel seque

Objective: The addition of adjuvant chemotherapy after surgical resection has improved survival rates for patients with pancreatic ductal adenocarcinoma (PDAC). However, outside clinical trials, many operated patients still do not receive adjuvant chemotherapy due to clinical and tumor-related factors. The aim of this study was to investigate factors that may influence the receipt of adjuvant chem

Detta examensarbete introducerar ett nytt förslag på användning av nedlagda skolor, fabrikslokaler, vårdinstitutioner, och andra övergivna anläggningar som står tomma runt om på Sveriges landsbygd. Behovet av funktioner dessa byggnader en gång var ämnade för saknar idag efterfrågan och jag vill lyfta potentialen sådana platser kan ha för särskilda användningsområden, i jämförelse med att bygga nyt

Hur kan naturliga dagvattensystem förhindra översvämningar i våra städer? Kraftigare skyfall och fler hårdgjorda ytor ökar risken för översvämningar i städer. I detta arbete utvecklades en metod för att undersöka bästa möjliga placering av blågröna lösningar för att avlasta vattenledningarna i området. Denna metod tillämpades senare på ett område i Lund där olika lösningar simulerades och effektiClimate change and increasing urbanization pose significant challenges to our urban environment. Urbanization leads to more impermeable surfaces, which, in combination with more rainfall, put communities at risk of flooding due to combined sewer overflows or overloaded drainage systems. To combat urban flooding, natural systems, also called blue-green solutions, can be implemented to mimic the nat

Simulating temporal changes in breast tissue has been challenging, despite advancement in virtual clinical trials. This study aims to enable virtual trials over time, motivated by interest in the effect of tissue involution on tumor visibility. We present a framework for creating 3D voxel-based breast phantoms and lesions using in-house Perlin Noise-based algorithm. The framework consists of three

Aims: The objective of this study was to compare the risk of developing type 1 diabetes in individuals with celiac disease, hyperthyroidism and hypothyroidism to that of individuals without those conditions. Materials and Methods: In this retrospective, observational, matched-cohort study based on real-world claims data, individuals with at least one diagnosis of celiac disease, hyperthyroidism (e

En förflyttning av bilresor till cykeltrafik har många fördelar, t.ex.förbättrad folkhälsa genom ökad fysisk aktivitet och minskadeföroreningar och trängsel. En slät yta med adekvat friktion är viktigt förcyklisternas trafiksäkerhet, komfort och framkomlighet. Sprickor ochojämnheter är vanligt förekommande underhållsrelaterade brister som ärkopplade till cykelvägens nedbrytning. Ett syfte med den A shift in modal share from car driving to cycling has many benefits, e.g.,health benefits from increased physical activity and less pollution andcongestion. A smooth cycle path surface with sufficient friction isimportant for cyclist traffic safety, comfort and level of service. Cracks andsurface unevenness are frequent maintenance-related deficienciesassociated with the degradation of the struct

Mobile, near-source measurements are broadly used for determining δ13CH4 of individual methane (CH4) emissions sources. To answer the need for robust and comparable measurement methods, we aim to define the best practices to determine isotopic signatures of CH4 sources from atmospheric measurements, considering instrument accuracy and precision. Using the Keeling and Miller-Tans methods, we verify