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Background: First-line managers in healthcare operate in increasingly complex environments marked by high demands, rapid change, and limited resources. These conditions impact their health, leadership capacity, and the sustainability of their roles. While previous research has addressed various aspects of leadership in healthcare, there is a lack of studies focusing specifically on how first-line
The evacuation of hospitals in the event of fires and similar emergencies can be a difficult endeavor. Patients usually require assistance, with a considerable number of them being unable to evacuate by themselves due to medical conditions or due to the treatment they are receiving. Assistance is to be provided by the healthcare staff in the affected ward, which means that their level of preparedn
Background: Optimal treatment and support in family planning for women with type 1 diabetes (T1D) and follow-up during pregnancy are important, however, there is limited knowledge from the women’s perspective on their considerations of family planning, pregnancy, and motherhood. Objectives: To explore expectations and experiences of family planning, pregnancy, and motherhood among women with T1D.
Background: Early identification of patients with suspected infection who are at risk of clinical deterioration in the Emergency Department (ED) is challenging, yet crucial for timely initiation of appropriate care and prevention of clinical deterioration. This multicenter international study evaluates the performance of established scores (SIRS, LODS, qSOFA, SOFA, NEWS) in predicting severe outco
Background: T cell receptor (TCR) binding properties have been related to a wide range of pathological conditions, including infections, autoimmunity and cancer. Characterising the TCR repertoire is of great biomedical interest but it has been challenging due to its high structural diversity. Methods: In situ sequencing (ISS) is a suitable technique for spatial cell typing and linking gene pattern
BackgroundPediatric heart-lung transplantation (pHLTx) remains the only treatment option for children with significant and fixed elevation of pulmonary vascular resistance (PVR) in the setting of uncorrectable end-stage heart disease. We aimed to determine the characteristics, waiting list course and long-term outcomes for children listed for pHLTx within the Scandiatransplant region.MethodsThis w
Introduction:Exclusive breastfeeding (EB) is globally recommended due to health benefits for women and their infants. Home-based postnatal midwifery care (HBPMC) is a model of care where midwives give in-home care during the first postnatal week. The study objectives were to investigate breastfeeding outcomes at two months after birth, in women and newborns receiving HBPMC, and to identify risk fa
Sustainable bioenergy is central to climate change mitigation, yet biomass supply depends not only on biophysical and economic assessments but also on farmers' decision-making. Straw from cereal and oilseed crops can support renewable energy, but its availability is constrained by on-farm uses, management practices, and farmers' access to knowledge of sustainable soil management. Because straw rem
Introduction Endometriosis is a chronic, inflammatory and oestrogen-dependent disease frequently causing infertility. Assisted reproductive technologies (ART) are often required to achieve pregnancy, especially in women with advanced endometriosis. To date, there is no randomised controlled trial (RCT) exploring reproductive outcomes after first-line surgery followed by ART versus first-line ART i
Understanding the spatiotemporal dynamics of dissolved organic carbon (DOC) is essential for predicting aquatic carbon fluxes and managing water quality in boreal catchments. Traditional DOC modelling approaches are limited in their ability to represent seasonal dynamics, event-driven responses, and riparian-zone contributions. Here, we evaluate the performance of the Krycklan-HYPE model in simula
Background: Continuous glucose monitor (CGM) devices enable characterization of individuals' glycemic variation. However, there are concerns about their reliability for categorizing glycemic responses to foods that would limit their potential application in personalized nutrition recommendations. Objectives: We aimed to evaluate the concordance of 2 simultaneously worn CGM devices in measuring pos
Background: The protein C anticoagulant system plays a key role in maintaining the hemostatic balance. Although several studies have identified thrombomodulin gene (THBD) variants among venous thromboembolism (VTE) patients, the role of THBD in relation to VTE in humans remains to be clarified. Objectives: This study aimed to determine the thrombotic risk of rare and common THBD variants in a larg
Long-term survival after childhood cancer often comes at the expense of late, adverse health conditions. However, survivorship care is frequently not available for adult survivors in Europe. The PanCareFollowUp Consortium therefore developed the PanCareFollowUp Care Intervention, an innovative person-centred survivorship care model based on experiences in the Netherlands. This paper describes the
