Background Worse outcomes have been noted in patients with multiple primary melanomas (MPMs) than in patients with single primary melanomas. Objective We investigated how family history of melanoma and germline CDKN2A mutation status of MPM patients affects risks of developing subsequent melanomas and other cancers and survival outcomes. Methods Comprehensive data on cancer diagnoses and deaths of

Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes development remains poorly understood. The aim of this study was to identify novel islet lncRNAs differently expressed in type 2 diabetes models and to inv

Corrosion of steel reinforcement is a common cause of deterioration in reinforced concrete bridges and many existing bridges are damaged to varying degrees. The rate of deterioration of the bridge stock has been shown to increase due to climate change. Unsympathetically, the demand for load-carrying capacity is however often increased with time. Therefore there is an increasing need for reliable m

AIMS:Register data allow for nuanced analyses of heterogeneities between sub-groups which are not observable in other data sources. One heterogeneity for which register data is particularly useful is in identifying unique migration histories of immigrant populations, a group of interest across disciplines. Years since migration is a commonly used measure of integration in studies seeking to unders

AIM: The relative roles(s) of impaired insulin secretion vs. insulin resistance in the development of gestational diabetes mellitus depend upon multiple risk factors and diagnostic criteria. Here, we explored their relative contribution to gestational diabetes as defined by the WHO 1999 (GDM1999) and adapted WHO 2013 (GDM2013) criteria, excluding the 1-h glucose value, in a high-risk Indian popula

Objectives To study the association between lifestyle risk factors and chronic hypertension by history of hypertensive disorders of pregnancy (HDP: gestational hypertension and pre-eclampsia) and investigate the extent to which these risk factors modify the association between HDP and chronic hypertension. Design Prospective cohort study. Setting Nurses' Health Study II (1991-2013). Participants 5

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used in colorectal surgery due to their opioid-sparing effect. However, several studies have indicated an increased risk of anastomotic leakage following NSAID treatment, although conflicting results exist. The primary goal of this study was to further examine whether postoperative NSAIDs are independently associated with a

Context: Variation in genes that cause maturity-onset diabetes of the young (MODY) has been associated with diabetes incidence and glycemic traits. Objectives: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. Design and Setting: This was a secondary analysis of a multicenter, randomized clinical trial, the D

The stable isotope of carbon, 13C, has been used in several studies for source characterization of carbonaceous aerosol since there are specific signatures for different sources. In rural areas, the influence of different sources is complex and the application of δ13C for source characterization of the total carbonaceous aerosol (TC) can therefore be difficult, especially the separation between bi

Recent research on human nonverbal vocalizations has led to considerable progress in our understanding of vocal communication of emotion. However, in contrast to studies of animal vocalizations, this research has focused mainly on the emotional interpretation of such signals. The repertoire of human nonverbal vocalizations as acoustic types, and the mapping between acoustic and emotional categorie

Objective: To implement a mendelian randomization (MR) approach to determine whether type 2 diabetes mellitus (T2D), fasting glucose, fasting insulin, and body mass index (BMI) are causally associated with specific ischemic stroke subtypes. Methods: MR estimates of the association between each possible risk factor and ischemic stroke subtypes were calculated with inverse-variance weighted (convent

Whilst Building Information Modelling (BIM) promises significant improvements in construction quality and efficiency, current contractual models do not encourage its use; indeed actively inhibit the collaboration at its core. To help bring BIM into the mainstream, it is claimed we need to re-craft existing contractual relationships to facilitate collaborative decision making and to equitably alloc

Scania, the dangerous peninsula. History, identity and ideology 1865 to 2000 This dissertation deals with the organized written history of Scania 1865 to 2000 and the intersection of history, identity and ideology. Under what circumstances were the history produced and circulated? What was its significance for identity and ideology alike? The theoretical and analytical inspiration is drawn from P

Existing installations and energy systems in most commercial buildings could be used in a more efficient way to provide savings – both in terms of energy and load demand. The key for effective operation is a thorough and detailed analysis of energy use patterns that creates essential baseline for energy savings and the development of demand response (DR) strategies. The knowledge of energy deman

Society has a responsibility to aid its citizens in case of emergency. This calls for planning and preparations. However, societal emergency response activities are not always fully effective. This might be due to suboptimal emergency planning and preparations, with some planned response actions not working as intended. For example, it is possible that some actions show to be ‘over-planned’ with t