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Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without T2D, using whole-genome bisulfite sequencing and RNA sequencing. We discover 22,544 differentially methylated regions annotated to 7,975 genes i
BACKGROUND AND PURPOSE: Pain as a long-term outcome following rectal cancer treatment has received limited attention in previous studies. This prospective cohort study examined pain prevalence up to 5 years post-surgery in patients treated with curative intent. Secondary aims included evaluating pain intensity and its interference with daily life, and comparing pain experiences with a reference po
This thesis aims to advance our understanding of how directors’ values influence board decision-making and firm behavior by developing and testing a model that integrates insights from behavioral perspectives on boards of directors and corporate governance. Ideally, boards engage in intensive and open discussions that utilize the full cognitive capacity of their members. However, in practice, they
Introduction: Survivors of critical illness commonly experience physical, cognitive, and psychological impairments. Early rehabilitation may mitigate these impairments; however, how rehabilitation practices are perceived and implemented by healthcare professionals in intensive care unit (ICU) remains insufficiently described. This study aimed to describe healthcare professionals' perceptions of re
BACKGROUND: Our aim was to explore the reasoning and experiences of women when offered a self-sampling HPV test.METHODS: This study implemented a qualitative study design and content analysis using an inductive approach. Data consisted of written narratives collected through open-ended questions from a total of 173 women. Women were included if they had been offered a self-sampling device since Se
With an increasing demand for rural resources and land, new challenges are approaching affecting and restructuring the European countryside. While creating opportunities for rural living, it has also opened a discussion on rural gentrification risks. The concept of rural gentrification encircles the influx of new residents leading to an economic upgrade of an area making it unaffordable for local With an increasing demand for rural resources and land, new challenges are approaching affecting and restructuring the European countryside. While creating opportunities for rural living, it has also opened a discussion on rural gentrification risks. The concept of rural gentrification encircles the influx of new residents leading to an economic upgrade of an area making it unaffordable for local
Objective The basis for protein synthesis is the genetic code. Many of these proteins will affect intermediary metabolites by acting as enzymes, hormones, or by other actions. The aim of the present study was to assess the relationships of a large number of proteins with endogenous metabolites. Methods Plasma protein levels were measured by the proximity extension assay (PEA) and metabolites by ma
BackgroundObesity is commonly diagnosed using BMI, which does not capture total adiposity or fat distribution, as highlighted by the recent Lancet D&E Commission report. We assessed the prognostic value of an adiposity-based classification combining body fat percentage (BF%) and waist circumference (WC) in relation to cardiometabolic and kidney outcomes and evaluated its concordance with BMI.M
Aims: Fetal insulin is a key regulator of fetal growth and the major contributor to high birth weight in pregnancies with maternal diabetes. There is evidence for genetic variation in regulating fetal insulin, but this has not been studied on a large-scale. We performed a genome-wide association study (GWAS) of umbilical cord insulin and c-peptide measurements to identify genetic variants associat
Introduction: Adolescents are increasingly exposed to hate speech in both online and offline contexts, yet limited research has examined how such exposure is experienced and how it relates to adolescents' psychological needs and well-being. Drawing on Self-Determination Theory (SDT), this study explores how adolescents make sense of hate speech and how these experiences affect autonomy, competence
BACKGROUND AND OBJECTIVES: – The prognosis for functional independence after aneurysmal subarachnoid hemorrhage (aSAH) relies largely on patients' initial clinical status, age, and extent of the bleeding. However, some patients have poor outcome despite initially being in good clinical condition. The aim of this study was to analyze factors related to unfavorable outcome in patients with good clin
BackgroundCytoreductive surgery is central to the management of advanced ovarian cancer. As the extent of surgery varies widely, assessment of postoperative risk is challenging. The Karolinska Surgical Extent and Complexity Score (K-SECS) was developed to quantify surgical extent and has previously been associated with survival. This study evaluated whether K-SECS is also associated with major pos
AimsSocial participation is an important determinant of health-related behaviours and health. Communication disorders such as stuttering may be associated with participation. Research concerning the association between stuttering and social participation among older adults is scarce. Therefore, the aim of this population-based cross-sectional study was to investigate associations between self-perc
