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Background: Periprocedural stroke during transcatheter aortic valve implantation is a rare but devastating complication. The calcified aortic valve is the most likely source of the emboli in a periprocedural stroke. The total load and distribution of calcium in the leaflets, aortic root, and left ventricular outflow tract varies from patient to patient. Consequently, there could be patterns of cal

Seagrass meadows are important ecosystem engineers, providing habitat for a range of marine organisms which sustain many ecosystem functions. Due to global loss of seagrass, conservation and restoration incentives are rapidly increasing. However, it is not well understood how environmental setting affects the structural and functional diversity of macrofaunal communities in eelgrass meadows (Zoste

In times of emergent emphases on how climate change will affect welfare societies, welfare policies and individuals’ welfare and vice versa, this study investigates public support for welfare and environmental policies and concerns. Since previous research and literature have pointed towards a socioeconomic divide between the welfare agenda and the environmental agenda in terms of public support,

Adopting circular business models (CBM) represents a key lever for industry to address urgent global challenges. Prior research recognizes the need for systems thinking and collaboration, but existing CBM tools and methods often implicitly assume that the focal firm has direct access to end customers, usage data and end-of-life phases. However, upstream suppliers who lack this access often produce

Background: To prevent severe contractures and their impact on adjacent joints in children with cerebral palsy (CP), it is crucial to treat the reduced range of motion early and to understand the order by which contractures appear. The aim of this study was to determine how a hip–knee or ankle contracture are associated with the time to and sequence of contracture development in adjacent joints. M

The agricultural sector has a critical role in creating social and environmental value of natural resources in addition to its traditional role of creating economic value by supplying food to the ever-increasing world population. In fulfilling this dual role, the agricultural sector often faces competing pressures: to operate financially profitable businesses and to create, maintain, and benefit f

Due to the growing awareness that insects' diversity and populations are in decline, there is an increased need for monitoring insects. Entomological lidars and photonic sensors can monitor and remotely identify flying insects based on their backscattered signal in terms of oscillations-, polarization-, and spectral content. The backscattered light from insects is predominantly oscillatory and der

BACKGROUND: Research involving multimorbid older patients is gaining momentum. However, little is known about how to plan a randomised controlled trial (RCT) involving this group of patients. An evidence-based approach to the challenges of a recruitment process could guide researchers and help prevent underpowered trials.AIM: To define the number of multimorbid older patients that need to be ident

BACKGROUND: Antibody-based constructs for molecular imaging and therapeutic delivery provide promising opportunities for the diagnosis and treatment of atherosclerosis.OBJECTIVES: The authors aimed to generate and characterize immunoglobulin (Ig)G monoclonal autoantibodies in atherosclerosis for targeting of novel molecular determinants.METHODS: The authors created hybridomas from an unimmunized l

Thyroid function has a widespread effect on the cardiometabolic system. However, the causal association between either subclinical hyper-or hypothyroidism and the thyroid hormones with blood pressure (BP) and cardiovascular diseases (CVD) is not clear. We aim to investigate this in a two-sample Mendelian randomization (MR) study. Single nucleotide polymorphisms (SNPs) associated with thyroid-stimu

Purpose/Background: Appendectomy is the standard treatment of acute appendicitis (AA) but conservative treatment has gained success. The need for follow-up after conservatively treated AA is unclear. Hypothesis/Aim: This study evaluates follow-up, recurrence and appendiceal malignancy in conservatively treated AA. Methods/Interventions: This retrospective study included patients with conservativel

Migration includes re-starting and re-building a life course. It begins with re-imagination of the journey and the kind of life that is going to take shape in the receiving society. One steps in a migratory journey with knowledge of the past experiences of dealing with risks through, among others, developing an understanding about one’s body. With migration, bodies get displaced, emplaced, replace

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with limited treatment options, illustrating an urgent need to identify new drugable targets in PDACs.OBJECTIVE: Using the similarities between tumor development and normal embryonic development, which is accompanied by rapid cell expansion, we aimed to identify and characterize embryonic signaling pathways that

Preventing and mitigating damage to the surroundings arising from process safety incidents is an important aspect of process safety. Risk-informed or risk-based decision-making are cornerstones in most countries’ regulatory regimes for land-use planning. However, the design and implementation of the regulations vary significantly - from countries that have chosen a highly standardized set of rules

Lake–atmosphere carbon exchanges can be significantly affected by photochemical dissolved organic matter (DOM) mineralization. However, our understanding of how increasing allochthonous organic carbon input affects the photoreactivity of DOM per unit of absorbed incoming light is incomplete. Here, we measured the absorption of ultraviolet (UV) light and subsequent photochemical DOM decay in 148 la

The Varena Iron Ore deposit in the SW East European Craton is a significant ore body that occurs within metamorphosed and hydrothermally reworked Paleoproterozoic dolostones. We have performed microstructural investigations supplemented with mineral chemistry and geochronological investigations (LA-ICP-MS) to obtain age constraints on the ore-forming event(s) and improve the understanding of the c

Background: Obesity is a major public health concern associated with various health problems, including respiratory impairment. Bioelectrical impedance (BIA) is used in health screening to assess body fat. However, there is no consensus in healthcare on how body fat should be assessed in relation to lung function. In this study, we aimed to investigate how BIA in relation to waist circumference co

Dietary patterns that include an excess of foods rich in saturated fat are associated with brain dysfunction. Although microgliosis has been proposed to play a key role in the development of brain dysfunction in diet-induced obesity (DIO), neuroinflammation with cytokine over-expression is not always observed. Thus, mechanisms by which microglia contribute to brain impairment in DIO are uncertain.