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Overall health relies on features of skeletal muscle that generally decline with age, partly due to mechanisms associated with mitochondrial redox imbalance and bioenergetic dysfunction. Previously, aged mice genetically devoid of the mitochondrial NAD(P)+ transhydrogenase (NNT, encoded by the nicotinamide nucleotide transhydrogenase gene), an enzyme involved in mitochondrial NADPH supply, were sh
Purpose: As social infrastructures, public libraries are increasingly recognised as providing more than access to books and information; librarians’ work is importantly centred around practices of care. However, the ways in which they provide care is poorly researched, let alone conceptualised. This paper explores how this important part of librarians’ daily work is practiced through the lens of i
Purpose: S. aureus bacteremia (SAB) is a common and severe infection with high mortality and morbidity. The clinical relevance of the finding of concurrent S. aureus bacteriuria (SABU) is debated. The goal of this study was to analyze whether a concurrent SABU is associated with complicated SAB, infective endocarditis (IE) and mortality. Methods: We conducted a retrospective cohort study, reviewin
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programs are being increasingly emphasized. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb+) child
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programmes are being increasingly emphasised. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb+) chi
Chronic obstructive pulmonary disease (COPD) is commonly caused from smoking cigarettes that induce biological stress responses. Previously we found disorganized endoplasmic reticulum (ER) in fibroblasts from COPD with different responses to chemical stressors compared to healthy subjects. Here, we aimed to investigate differences in stress-related gene expressions within lung cells from COPD and
Background The COVID-19 pandemic has presented many countries with significant health system and economic challenges. The role of civil-military cooperation in a health crisis of the magnitude presented by COVID-19 remains virtually unexplored. This review aims to detect and identify typologies, if any, of associations between security or military systems and the national response measures during
The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor for FOL-005 and the more stable analogue FOL-026. X-ray diffraction and microscale thermophoresis analysis revealed that FOL-026 shares binding si
Sverige har i över 25 år kritiserats internationellt av bl.a. CPT för den frekventa användningen av restriktioner vid häktning. Forskning har visat att restriktioner vid häktning kan leda till att den misstänktes psykiska hälsa försämras. I förlängningen kan detta negativt påverka dennes möjligheter till att försvara sig. I augusti 2016 publicerades SOU 2016:52 som bland annat behandlar förslag om
3:12-reglerna är beteckningen på de särskilda regler som gäller för beskattningen av fåmansföretag. För att omfattas av reglerna krävs det att företaget är ett fåmansföretag enligt någon av de tre definitionerna samt att delägarens andel är kvalificerad. Genom ett gränsbelopp avgörs hur stor del av en utdelning som kan beskattas som kapitalinkomst. Ett utrymme som löneunderlagsregeln kan utöka. FrThe 3:12-rules is the name of the special rules that regulates the taxation of closely held corporations. In order for the rules to apply, a corporation must fit one of the three definitions and the partner’s share must be qualified. The dividend allowance determines the amount that may be taxed as capital income. It is possible to expand this amount by including a wage based dividend allowance. T
Den gränsöverskridande handeln spelar en central roll för EU-samarbetet, men offentliga upphandlingar är fortfarande en i huvudsak nationell angelägenhet. I en alltmer globaliserad värld kommer dock gränsöverskridande upphandlingar att spela en allt större roll. Likaledes kan gränsöverskridande samarbeten mellan upphandlande myndigheter komma att öka, för att kunna dra nytta av den inre marknadensCross-border trade is of special significance to the European cooperation, but public procurement is still mainly a national concern. Cross-border joint public procurement will play an even larger part in a more global world. Such collaboration between contracting authorities may also increase, in order to derive maximum benefit from the potential of the internal market in terms of economies of sc
Vid prövning av huruvida grov kvinnofridskränkning föreligger är det idag möjligt för domstolar att använda tidigare lagakraftvunna domar för att nya gärningar ska uppfylla rekvisitet upprepad kränkning. Domstolarna använder sig däremot inte av tidigare lagakraftvunna domar för att rekvisitet brottsliga gärningar ska vara uppfyllt. Syftet med denna uppsats är att utreda om det strider mot principeGross violation of a woman’s integrity is a crime that consists of multiple criminal acts. During the trial of gross violation of a woman’s integrity is it possible for the court to use legally binding judgements to fulfil the requisite repeated violation. The court does not use legally binding judgements to fulfil the requisite criminal acts. The purpose of this essay is to examine if the use of
Frågan om de psykiskt sjuka brottslingarnas straffrättsliga ställning har debatterats flitigt de senaste hundra åren. De frågor som särskilt stått i fokus har varit tillräknelighetens roll för det straffrättsliga ansvaret, samt hur påföljdssystemet för psykiskt sjuka brottslingar borde se ut. I denna rättshistoriska uppsats har syftet varit att undersöka på vilket sätt synen på psykiskt sjuka broThe question of the mentally ill offenders’ status in the justice system has been intensely debated over the last hundred years. The issues which have been most discussed have been the importance of the defendants’ accountability, as well as how the punishment system for mentally ill offenders should be constructed. The purpose of his legal history essay has been to examine how the view of the me
Gång- och cykelvägar (gc-vägar) har blivit en allt hetare fråga i dagens moderna och mer miljö- och hälsomedvetna samhälle. Det planeras för fler gc-vägar mellan orter, men det råder osäkerhet kring hur rätten till dem ska säkras och flera alternativa lösningar har tillämpats. Vidare finns det oklarheter gällande vem som ska vara ansvarig för anläggande och drift av gc-vägarna. Det här examensarbeCombined walkways and bicycle paths has become an intriguing topic in today’s modern society with more focus on both health and the environment. There are plans for more combined walkways and bicycle paths between villages, but there is an uncertainty regarding how to secure the right to them. In addition legal custom regarding land access is scarce. When land is requisitioned for combined walkw
