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Until recently, the study of nutrient patterns was hampered at an international level by a lack of standardization of both dietary methods and nutrient databases. We aimed to describe the diversity of nutrient patterns in the European Prospective Investigation into Cancer and Nutrition (EPIC) study at population level as a starting point for future nutrient pattern analyses and their associations
Genome wide association studies (GWAS) identify susceptibility loci for complex traits, but do not identify particular genes of interest. Integration of functional and network information may help in overcoming this limitation and identifying new susceptibility loci. Using GWAS and comorbidity data, we present a network-based approach to predict candidate genes for lipid and lipoprotein traits. We
Background-eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). Methods and Results-In a genome-wide association analysis of 2078 CAD cases and 2953 control subjects, we identified 950 single-nucl
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and unknown environmental triggers. In most countries, only 10-15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. Autoantibodies against insulin, GAD65, IA-2 or the ZnT
BACKGROUND: CYP2J2 is responsible for the production of 5,6 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature. Carriers of a common polymorphism, the CYP2J2-50G>T, rs890293, have reduced expression of CYP2J2 mRNA level in the heart putatively through the interference with
Objective Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 autoantibodies in patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well as its relation with the insulin (INS) or the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms. Subjects and
Gendered differences concerning intellectual and physical religious expressions in medieval Europe have previously been discussed by several medievalists. It has been suggested that medieval male piety was expressed primarily in practical and intellectual terms within canonical rituals and in verbalized form in prayers and mass. Female piety, on the other hand, is thought to have been expressed in
Something has happened in the field of Service Studies. With the introduction of what has been called Service Dominant Logic a large proportion of the established theories related to service as a phenomenon has been challenged. From previously having been defined as something different from the tangible things we buy (goods); i.e. a residual, service defined out of what service is not, the new lin
Insulin replacement therapy is considered the only effective and feasible treatment for type 1 diabetes mellitus (T1DM) as only insulin is capable of reversing the metabolic disturbances and restoring a near - normal quality of life in patients with T1DM. Despite rigorous measures and major advances in health care provided for patients with T1DM, increased morbidity and mortality are still common
Existing installations and energy systems in most commercial buildings could be used in a more efficient way to provide savings – both in terms of energy and load demand. The key for effective operation is a thorough and detailed analysis of energy use patterns that creates essential baseline for energy savings and the development of demand response (DR) strategies. The knowledge of energy deman
1.Among small animals dispersal parameters are mainly obtained by traditional methods using population studies of marked individuals. Dispersal studies may underestimate the rate and distance of dispersal, and be biased because of aggregated habitat patches and a small study area. The probability of observing long distance dispersal events decreases with distance travelled by the organisms. In thi
Scania, the dangerous peninsula. History, identity and ideology 1865 to 2000 This dissertation deals with the organized written history of Scania 1865 to 2000 and the intersection of history, identity and ideology. Under what circumstances were the history produced and circulated? What was its significance for identity and ideology alike? The theoretical and analytical inspiration is drawn from P
STUDY OBJECTIVE: To assess whether in an urban population stage at breast cancer diagnosis is related to area of living and to what extent intra-urban differences in breast cancer mortality are related to incidence respectively stage at diagnosis. DESIGN: National registries were used to identify cases. Mortality in 17 residential areas was studied in relation to incidence and stage distribution u
Although it is generally anticipated that innovation as such leads to regional prosperity (Asheim et al. 2011) there is lack of empirical evidence that confirms the direct linkage between the innovation capabilities of regions and welfare increase. It is suggested that entrepreneurship can be seen as a missing link that helps to transfer innovations into business outcomes (Braun et al. 2012). The
Society has a responsibility to aid its citizens in case of emergency. This calls for planning and preparations. However, societal emergency response activities are not always fully effective. This might be due to suboptimal emergency planning and preparations, with some planned response actions not working as intended. For example, it is possible that some actions show to be ‘over-planned’ with t
