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Coronary heart disease (CHD) is an archetypical multifactorial disorder that is influenced by genetic susceptibility as well as both modifiable and nonmodifiable risk factors, and their interactions. Advances during recent years in the field of multifactorial genetics, in particular genomewide association studies (GWASs) and their meta-analyses, have provided the statistical power to identify and

Background: The Patient-Reported Indices for Multiple Sclerosis (PRIMUS) comprises a suite of three scales for assessing symptoms, activity limitations, and quality of life in multiple sclerosis (MS). It was developed in the UK and has been shown to have excellent psychometric properties. This study describes the adaptation of eight language versions for Canadian English, Canadian French, French,

Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate islet hormone secretion in a paracrine and autocrine manner in rodents. Hitherto, no studies demonstrate a role for this amine in human islet function, nor is it known if 5-HT signaling is involved in the development of beta cell dysfunction in type 2 diabetes (T2D). To clarify this, we performed a complete transcriptional mapping

Genetics, epigenetics and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts. In adipose tissue from discordant twins, we found decreased expression of genes

Microdialysis was used to monitor local concentrations of energy metabolites in different organs, and to study the pharmacokinetics of morphine over the blood-brain barrier in intact and injured brain tissue in conditions treated in the Intensive Care Unit. After major abdominal or thoracoabdominal surgery, postoperative thoracic epidural analgesia resulted in higher glycerol concentrations in th

Whistle-blowing can serve as a powerful mechanism helping policy-makers and other stakeholders recognize ethical misconduct and other types of wrongdoing in autonomous public agencies. This mechanism is of particular importance in major public sector reforms, such as agency mergers, when it may be difficult to secure continuity in the quality of organizational processes. Yet, we know little of wha

As the saying goes, “a beloved child has many names”. So, too, is the case with the concept to be dealt with in this paper. Over the years various concepts have been used to denote education in a lifetime perspective, such as “education permanente”, recurrent education and lifelong learning. There are many who have disputed the correctness or appropriateness of one or the other concepts. Boudard (

The injury risk for bus passengers is low compared to car users. However, bus passengers also run the risk of sustaining injuries as vulnerable road users: as pedestrians or cyclists to and from the bus stop. Among vulnerable road users, seniors are a particularly important group. Hitherto, injury data have mainly been based on police-reported accidents. These accidents reveal bus occupant safety,

The aim of this study is to generate a quality-controlled sub-kilometer dataset of the fraction of absorbed photosynthetically active radiation (FAPAR) across Scandinavia from satellite. FAPAR is required for estimating the amount of PAR absorbed (APAR) by vegetation, which in turn allows for estimation of carbon uptake. In this study, FA-PAR was modeled from normalized difference vegetation index

This report discusses the role of the program coordinator in a faculty where the organisation of connected and integrated courses in bachelor programmes is a fairly new phenomenon. In the Faculties of Humanities and Theology at Lund University there has been a strong tradition to design an individual bachelor exam by combining independent courses. During the last ten years an increasing number of

Introduction: Heterogeneity in cognitive outcomes and response to treatment has been described in Alzheimer’s disease (AD). Using the method of mixed models, higher resolution can be obtained to identify potential predictors of long-term outcomes. Aims: To analyse the impact of the APOE genotype, non-steroidal anti-inflammatory drug (NSAID) therapy and cholinesterase inhibitor treatment (ChEI) on

Havsnivåhöjning till följd av klimatförändringar ökar risken för översvämningar vid kusten och nödvändiggör konstruktionen av skyddsvallar och andra kustskyddsåtgärder. Vegetation vid kusten kan vara en del i dessa skyddsåtgärder genom att reducera våghöjden på de inkommande vågorna. Detta examensarbete kvantifierar vågdämpningen från vegetation vid Bunkeflo strandängar (Malmö) med hjälp av en emp

People who desire more-than-one gender are still facing social exclusion as well as exclusion from LGBTQ communities. Moreover, specific bi+ spaces are rare and bisexuals are often not part of them. Where, then, do bisexuals belong? In order to answer this question, this thesis explores the everyday experiences of bi+ people using Relief Maps and in-depth interviews. I build on theories around emo