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Discriminative prediction of A-To-I RNA editing events from DNA sequence

RNA editing is a post-transcriptional alteration of RNA sequences that, via insertions, deletions or base substitutions, can affect protein structure as well as RNA and protein expression. Recently, it has been suggested that RNA editing may be more frequent than previously thought. A great impediment, however, to a deeper understanding of this process is the paramount sequencing effort that needs

Horizontal Carrier Coordination through Cooperative Governance Structures

This paper examines how governance structures found in the trucking industry impact the coordination between a forwarder and its carriers, including three cases: no forwarder coordination (direct contracting with shippers), investor-owned coordination (price-only contract), and carrier-cooperative coordination (revenue-sharing contract). The carriers are engaged in a Cournot competition, where the

The Integrated Carbon Observation System (ICOS) : Standardised observations for science and societies

To understand, predict and mitigate climate change, it is crucial to have long-term and standardised measurements of greenhouse gas concentrations in the atmosphere and their fluxes between atmosphere, land and oceans. The Integrated Carbon Observation System, is a distributed European Research Infrastructure which provides high-precision and highly standardised observations from more than 170 sta

Online Representations of Older People Generated by Public Sector Organizations

This article investigates the generation of online representations of older people by institutions. Specifically, it discusses the ways in which public sector organizations generate online representations of older people from a production perspective. This article uses the following questions to frame its analysis: What do we know about online representations of older people generated by public se

Malmö POTS symptom score : Assessing symptom burden in postural orthostatic tachycardia syndrome

BackgroundPostural orthostatic tachycardia syndrome (POTS) is a common cardiovascular autonomic disorder characterized by excessive heart rate increase on standing and symptoms of orthostatic intolerance, posing significant limitations on functional capacity. No objective tool exists to classify symptom burden in POTS.MethodsWe conducted a case-control study in 62 POTS patients and 50 healthy cont

Emotional labour in digital diplomacy: perceptions and challenges for European diplomats

Social media are increasingly important tools in diplomacy. Diplomats are expected to use social media platforms such as Twitter, Facebook and Instagram to communicate with each other and with both domestic and international publics. This form of communication involves displaying positive emotions to generate attention in a competitive information environment. Emotions are essential to managing pe

Modelling of power flow and losses in a conductive Electric Road System

As the market share of electric vehicles increases, the need for a charging infrastructure increases correspondingly. Modern Electric Road Systems is a cost effective charging infrastructure that allows electric vehicles to charge while driving and consequently allowing for smaller batteries in EVs. To assess the potential of electric road system technology, a demonstrator of conductive electric r

The Apparent Organ-Specificity of Amyloidogenic ApoA-I Variants Is Linked to Tissue-Specific Extracellular Matrix Components

Apolipoprotein A-I (ApoA-I) amyloidosis is a rare protein misfolding disease where fibrils of the N-terminal domain of the protein accumulate in several organs, leading to their failure. Although ApoA-I amyloidosis is systemic, the different amyloidogenic variants show a preferential tissue accumulation that appears to correlate with the location of the mutation in the protein sequence and with th

Screening for breast and cervical cancer among OST patients : a qualitative study of barriers and suggested interventions to increase participation

PURPOSE: Women with current or previous drug use are at risk of poor breast and cervical cancer outcomes. While screening is known to decrease cancer mortality, screening participation is sparsely investigated among drug dependent women. The aim of this study was to explore experiences of breast and cervical cancer screening-including barriers and suggested interventions to promote increased parti

Second-hand clothing markets and a just circular economy? Exploring the role of business forms and profit

Second-hand consumption of clothing can support the transition to circular economies by prolonging the lifespan of products through reuse. Historically, not-for-profit businesses have been dominant actors in second-hand markets across Western Europe and North America. However, with the growing interest in second-hand consumption, for-profit firms have increasingly entered this market over the last

The Geras Solutions Cognitive Test for Assessing Cognitive Impairment: Normative Data from a Population-Based Cohort

BackgroundThere is a need for the development of accurate, accessible and efficient screening instruments, focused on early-stage detection of neurocognitive disorders. The Geras Solutions cognitive test (GSCT) has showed potential as a digital screening tool for cognitive impairment but normative data are needed.ObjectiveThe aim of this study was to obtain normative data for the GSCT in cognitive

Citizen science initiatives increase pollinator activity in private gardens and green spaces

Wild insect pollinators are essential to cultivated and natural ecosystems globally. Today, many pollinator species are declining. One reason is a general lack of flowering habitats at landscape scales. However, urban areas, including private gardens, may provide flowers, and constitute beneficial habitats for pollinators. Here, we evaluate the ecological outcomes of a citizen science campaign run

How CSR Practitioners reformulate their calling through social-symbolic work practices over time

Calling has gained importance in the career and organization scholarship as a key concept to better explain the meaningfulness of work from a humanistic perspective. On the contrary, much debate remains about the ways a calling–and the meaningfulness intertwined with it–can transform over time. To respond to this problem in the literature, we investigate the calling of corporate social responsibil

Identifying Potential Indicators of Neighbourhood Solar Access in Urban Planning

Solar access describes the capacity of urban spaces to receive sunlight and daylight. Rapid urbanization and unbridled densification pose a threat to sustainable solar access, reducing the penetration of sunlight and daylight into cities. To effectively assess solar access at such an early design stage, at the urban planning level, it is critical that evaluation metrics are simple and reliable. Th

Plasma prostasin : a novel risk marker for incidence of diabetes and cancer mortality

Aims/hypothesis: Diabetes is associated with an increased risk of cancer. Prostasin is an epithelial sodium channel stimulator that has been associated with suppression of tumours, glucose metabolism and hyperglycaemia-associated tumour pathology. However, the association between prostasin, diabetes and cancer mortality has not been well investigated in humans. We aim to investigate the associatio