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Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D contribute to these phenotypes. We identify VPS39 as an important regulator of myoblast differentiation and muscle glucose uptake, and VPS39 is downregulated in myoblasts and myotubes from indi
Material decomposition in computed tomography is a method for differentiation and quantification of materials in a sample and it utilizes the energy dependence of the linear attenuation coefficient. In this study, a post-image reconstruction material decomposition method is constructed for a low-energy micro-CT setup using a photon counting x-ray detector. The low photon energy range (4–11 keV) al
Syfte: Cancerforskning och relaterade innovationsprocesser saknar ofta en viktig komponent; patientdeltagande. Vi nyanalyserar tre studier (a-c) för att undersöka hur teorin Nuets förnöjsamhet kan användas för att förbättra patientens deltagande och psykosociala hälsa.Metod: Vi återanalyserade data från den klassiska grundade teoristudien om Nuets förnöjsamhet, baserad på fyra års observation och Purpose: Cancer research and connected innovation processes often lack a major component; patient participation. We revisit three studies (a-c) in order to explore how Momentary contentment theory may be used to improve patient participation and psychosocial health.Method: We revisited data from the initial (a) classic grounded theory study on Momentary contentment, based on four years of observat
Background: Gastric bypass (GBP) is a surgical method with good evidence of sustainable weight loss, reduced obesity-related comorbidities, and improved health-related quality of life (HRQoL). However, long-term data post-GBP is scarce on HRQoL related to other factors than weight loss, such as impact of socio-economic, age, and gender. Aim: To investigate long-term HRQoL in GBP patients. Methods:
Many call for a broad approach to valuation of nature’s contribution to people, one that provides a contextualized understanding of what may be experienced as a value in different cultures, groups and settings. In the present paper we address contributions of nature to psychological well-being as realized through restorative processes during encounters with wildlife. Although restorative benefits
Current freight transport is highly dependent on fossil fuels and there is a need for a transition to alternative fuels and technologies. Biogas is a type of biofuel that has the potential to reduce climate emissions from freight transport, while providing additional benefits such as recycling of nutrients and increased energy security. This paper uses theories on the diffusion of green technologi
I denna studie görs en uppdaterad analys av den länsvisa tillgången på skogsbaserade rest- och biprodukter i form av grenar och toppas (grot) vid föryngringsavverkningar, bark från sågverk och massabruk, sågspån (och kutterspån) från sågverk samt lignin från svartlut i sulfatmassabruk som råvara för framtida produktion av biodrivmedel/bioflygbränsle. Analysen inkluderar också beräkningar av teoretThis study includes an updated analysis of the regional potential of forest-based residues and by-products in form of logging residues after final felling’s, bark in sawmills and pulp mills, sawdust in sawmills, and lignin from black liquor in pulp mills, as feedstocks for future production of biofuels and biojet fuels. The analysis also include calculations of theoretical transportation distances
The focus on cancer rehabilitation has increased, but breast cancer patients still report unmet rehabilitation needs. Since many women today will live long beyond their diagnosis, there are multiple challenges for the healthcare system in supporting these women in their new life situation. A more individualized approach is seen as necessary to optimize the rehabilitation for survivors. Pathographi
Are there indications for the neoliberal hegemony in economy and society to come to an end? Are people already imagining a future within environmental limits and beyond the growth imperative? Theoretically, building upon Marx and Bourdieu, we reconstruct the ideological impact that capitalism, in general, and neoliberalism, in particular, has on the ways we think, feel and make sense of our enviro
Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis profoundly attenuates atherosclerosis. As CD40L exerts multiple functions depending on the cell-cell interactions involved, we sought to investigate the function of the most relevant CD40L-expressing cell types in atheroscleros
Current sustainability assessment (SA) tools to help deal with contaminated groundwater sites are inherently subjective and hardly applied. One reason may be lack of proper tools for addressing contaminant spread which are basically objective. To fill this gap, there is a need for contaminant transport models that provide site managers with needed room for applying their judgments and consideratio
Reduced glucose metabolism and formation of polyglucosan bodies (PGB) are, beside amyloid beta plaques and neurofibrillary tangles, well-known pathological findings associated with Alzheimer's disease (AD). Since both glucose availability and PGB are regulated by enzymatic degradation of glycogen, we hypothesize that dysfunctional glycogen degradation is a critical event in AD progression. We ther
Aim: MicroRNAs play an important role in the maintenance of cellular functions by fine-tuning gene expression levels. The aim of the current study was to identify genetically caused changes in microRNA expression which associate with islet dysfunction in diabetic mice. Methods: To identify novel microRNAs involved in islet dysfunction, transcriptome and miRNome analyses were performed in islets of
