Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG with

A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in human pancreatic islets. A group of coexpressed genes (module), enriched for interleukin-1-related genes, was associated with T2D and reduced insulin secretio

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated wi

A three-phase hollow fiber liquid phase microextraction (HF-LPME) method was evaluated for the extraction and preconcentration of naproxen and diclofenac using a polypropylene membrane followed by analysis using HPLC or LC/MS. In this technique, the drugs were extracted into di-n-hexyl ether immobilized in the wall pores of a porous hollow fiber from 50mL of sludge slurry sample as a donor phase w

Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 interventio

Purpose of this paper The purpose of this paper is to propose a framework for describing and analyzing misalignments in supply chain management, which relate to changes in supply chain structures, processes, and management components. Design/methodology/approach Based on the systems approach, a single-case study with embedded design including several embedded cases from the same supply chain was

Though there is a very large literature examining whether energy use Granger causes economic output or vice versa this literature is fairly inconclusive. Almost all existing studies use relatively short time series or panels with a relatively small time dimension. Additionally, many recent papers continue to use what seem to be misspecified models. We apply Granger causality and cointegration tech

Problem: Problem som uppstår vid tillämpningen av internationella standarder, såsom EU taxonomin, är av vikt för standardsättare att förstå då ett mer utvecklat forskningsområde förbättrar förutsättningarna för nya internationella standarder att uppnå sitt syfte. Syfte: Syftet med flerfallsstudien är att bidra med ett nytt perspektiv till forskningsområdet implementering av internationella standaProblem: Problems that arise with the application of international standards, such as the EU taxonomy, are important for standard-setters to understand as a more developed research field will improve the qualifications for new international standards to attain their purpose. Purpose: The purpose of this multiple case is to contribute with another perspective within the research field implementing

Studien syftar till att undersöka medarbetares uppfattningar om intern kriskommunikation. I fallstudien studeras den svenska Försvarsmakten under de två första månaderna av kriget i Ukraina. Då tidigare forskning främst har fokuserat på det externa perspektivet av Försvarsmaktens kommunikation, avser denna studie att fylla det identifierade gapet gällande det interna perspektivet inom forskningsfä

Vi lever nu i en värld där naturresurserna används för att producera och konsumera mer än naturen kan hinna med. I slutändan så tar allting slut även det som idag kan se oändligt ut, dessutom så skadar överdrivit resursanvändningen även andra levande organismer och naturresurser. Byggsektorn i vår tid ansvarar för en stor del av resursanvändningen och även en stor andel av avfall generad i SverigWe live now in a world where natural resources are produced and consumed more than nature can keep up with. In the end everything ends, even that which seems infinite. In addition to that, the overuse of natural resources damages other living organisms and natural resources. The construction sector in our time is responsible for a large amount of the resource usage and also a large portion of the

This thesis explores the functions of memory, collective identity, and communication of those same categories to the reader by means of the poetic form in Hanna Rajs’ poetry collection Under månen (2020). Situated or framed within a discussion on Holocaust Literature, Rajs’ poetry is considered in the light of a general historical purview of Holocaust writing, and her specific place within an auth

Today, with many of the technological issues of integrated information management resolved (perhaps excluding the matter of interoperability), defining the content and status of BIM information deliveries remains both a practical and a theoretical problem. New BIM tools and new design processes and procedures have led to a certain confusion of what information is needed for particular BIM uses. Th

Background Primary Sjogren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with disease symptoms, and a primary role for the salivary gland parenchyma in disease development has been suggested. Specifically, dysfunction of exocrine pathways involving the muscarinic receptor 3 (CHRM3) has been indicated. Obje

Waste heat recovery systems for power generation are gaining interest among the marine transport sector as a solution to accomplish the upcoming more restrictive regulations on emissions, and to reduce the total fuel consumption. In this paper we evaluate how a waste heat recovery system based on a regenerative organic Rankine cycle (rORC) could improve the performance of a passenger vessel. The c