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Assertive Community Treatment (ACT) is the most common ambulatory service delivery model for people with severe mental illness worldwide. Flexible ACT, a Dutch modification of ACT, provides comprehensive care for the entire population of people with severe mental illness (SMI). FACT combines the principles of individual case management with ACT services. Researchers found an association between mo
PIWI-interacting RNAs (piRNAs) are important for ensuring the integrity of the germline. 3'-terminal 2'-O-methylation is essential for piRNA maturation and to protect them from degradation. HENMT1 (HEN Methyltransferase 1) carries out the 2'-O-methylation, which is of key importance for piRNA stability and functionality. However, neither the structure nor the catalytic mechanism of mammalian HENMT
Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patterns of medication use in hyperlipidemia, hypertension and type 2 diabetes in up to 193,933 individuals (55% women) in the FinnGen study. In meta-anal
Aims: To investigate if addition of metformin to standard care (life-style advice) reduces the occurrence of cardiovascular events and death after myocardial infarction (MI) in patients with newly detected prediabetes. Methods: The Myocardial Infarction and new treatment with Metformin study (MIMET) is a large multicentre registry-based randomised clinical trial (R-RCT) within the SWEDEHEART regis
This study investigates the role of multi-stakeholder networks in disaster risk management (DRM) capacity development and how it aligns with the principles of the Sendai Framework for Disaster Risk Reduction. While the Framework emphasises collaboration, coordination, and partnerships among diverse stakeholders, there remains a gap in understanding how networks foster and sustain collaborative DRM
COVID-19 has affected the daily activities of people worldwide. Recommendations introduced to reduce the spread of the virus led to increased use of Information and Communication Technologies (ICT) to meet everyday needs. Such rapid digitalization had not been seen previously and not been possible to study before. Hence, this study aimed to identify and describe self-reported changes in usage of a
Human genetic variation in PPARGC1B has been associated with adiposity, but the genetic variants that affect PPARGC1B expression have not been experimentally determined. Here, guided by previous observational data, we used CRISPR/Cas9 to scarlessly edit the alleles of the candidate causal genetic variant rs10071329 in a human brown adipocyte cell line (hBAs). Switching the rs10071329 genotype from
'Drawing from contributions by scholars of entrepreneurship from North America, Western Europe and Asia, this edited book celebrates the vibrancy and interdisciplinarity of entrepreneurship research. It showcases the renewed importance of entrepreneurship studies in the social sciences. New Movements in Entrepreneurship is a tour de force in entrepreneurship studies that must not be missed. It's b
This paper studies family commitment among fast-track professionals and explores how continued childbearing and union stability vary among high-achieving men and women. The focus is on three particular fast-track professional groups (e.g., lawyers, medical doctors and Ph.D.s), that face quite different career structures and work environments that may affect family life. The determinants of having
Previous research has consistently found demographic responses to grain price fluctuations in preindustrial Europe, both at macro and micro level. Grain prices serve as a summary measure of the workings of the preindustrial economy, reflecting not only local harvest conditions but trade patterns and market integration. All over preindustrial Europe the manorial estate was an important institution
In the effort to separate pedestrian and bicycle traffic from motorised traffic the solution often is to let the pedestrians and bicyclists share space. However, combined pedestrian and bicycle paths lead to problems for both pedestrians and bicyclists; for pedestrians it is a security and safety problem and for bicyclists a mobility problem. Seniors and visually impaired pedestrians are especiall
The almost complete focus on the aggregate level in previous research on demographic, socioeconomic and cultural determinants of the fertility transition means that we to a large extent not only lack knowledge about the specific mechanisms of the decline, but also its socioeconomic patterns. In this paper we explore socioeconomic fertility differentials in an industrializing community of southern
The myriad of interpersonal relationships in tourism, between tourists, between tourists and locals, and between tourists and the service providers, are essential, generic components of the tourist experience. However, interpersonal relationships are emerging as a commercial value in the tourism industry as well, expressed for example in rural commercial home type of businesses, and in wellness-or
Varying degrees of collaboration and consultation in the area of child and family welfare in the public sector has grown rapidly since the 1980s, especially concerning children at risk. Collaboration is understood to provide a more holistic view of the individual's needs, lead to better care and treatment as well as increase knowledge in general. Collaboration in that sense constitute a flexible a
A producer-independent, problem-oriented, group-education programme with 2-day meetings on drug treatment in primary health care (PHC) was developed and evaluated. Initially, it was tested on a selected group of general practitioners (district physicians), using a non-exposed group as control. A comprehensive questionnaire was used to test changes in attitudes. There was a significant change in at
Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular and intracellular fluids. Water balance is maintained by multiple mechanisms that continuously match water losses through urine, the skin, the gastrointestinal tract and respiration with water gains achieved through drinking, eating and metabolic water
