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Defining the role of common variation in the genomic and biological architecture of adult human height.

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants

Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet β cells?

Type 1 diabetes is a serious chronic disease in which the pancreatic islet beta cells are destroyed by autoimmunity specifically directed to intracellular autoantigens. Still undefined environmental factors are likely to initiate the disease process. One of the autoantigens is glutamic acid decarboxylase (GAD65) and attempts are made to induce immunological tolerance against this autoantigen. Alum

Climatic Thermal Stresses in the Vätösund Box-Girder Concrete Bridge

A Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity

Rare-variant association studies in common, complex diseases are customarily conducted under an additive risk model in both single-variant and burden testing. Here, we describe a method to improve detection of rare recessive variants in complex diseases termed RAFT (recessive-allele-frequency-based test). We found that RAFT outperforms existing approaches when the variant influences disease risk i

Professionalism and Organizational Performance in the Wake of New Managerialism

With New Public Management came the idea that public organizations should be led by professional managers, rather than by professionals. This has been referred to as new managerialism. This article explores how new managerialism may affect professional autonomy in a public organization that enjoys a high – and constitutionally protected – degree of organizational autonomy. A framework distinguishi

Tracking parental attitudes on vaccination across European countries: The Vaccine Safety, Attitudes, Training and Communication Project (VACSATC)

Utformning av talade utrymningsmeddelanden - erfarenheter från en enkätundersökning och oannonserade utrymningsförsök

Carrot psyllid (Trioza apicalis) winter habitats - insights in shelter plant preference and migratory capacity

The carrot psyllid (Trioza apicalis) is a serious pest in carrot-growing areas in northern and parts of central Europe. The psyllids overwinter as adults on conifers and during summer feed and lay eggs on carrot plants (Daucus carota ssp. sativus), thereby destroying the crop. To investigate the migratory capabilities and preferences for different shelter plant species of the carrot psyllid, we ma

Mellan frisk och sjuk : En studie av psykiatrisk öppenvård

Riktlinjer för handläggning av patienter med pankreascancer

Patient reactions to cancelled or postponed heart operations.

Placental histology and fetal blood flow in intrauterine growth retardation

Children looked after and their right to participation in accordance with the UN Convention on the Rights of the Child, article 12

Fathers and their children's health: a telephone interview study

Contributions of Oi, Oe and Oa horizons to dissolved organic matter in forest floor leachates

Participation in the prescription process of mobility devices - experiences among older patients

Patients above sixty years of age with Hodgkin's lymphoma treated with a new strategy

Taking automatic control into wood ash recycling

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Patients' experiences of consultations for nonspecific chronic orofacial pain: A phenomenological study

Aims: To use a qualitative research study to analyze the experiences of patients with nonspecific chronic orofacial pain with respect to consultations for their pain condition. Methods: Fourteen patients (11 women and 3 men; age range, 21 to 77 years) were strategically selected through a purposive sampling of the chronic orofacial pain patients referred to the Orofacial Pain Unit at the Faculty o