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Re-evaluation of HER2 status in 606 breast cancers—gene protein assay on tissue microarrays versus routine pathological assessment

Human epidermal growth factor receptor 2 (HER2) status in breast cancer is routinely determined through immunohistochemistry (IHC) and/or in situ hybridisation (ISH) performed on whole tissue sections (WS). The purpose was to evaluate whether a gene protein assay (GPA) combining IHC with ISH, performed on breast cancer tissue microarray (TMA), is suitable for large-scale retrospective HER2 status

Time to pregnancy and pregnancy outcome.

Objective: To investigate whether the outcome of a pregnancy is related to the time required to achieve that pregnancy (TTP). Design: The distribution of the TTP for pregnancies ending in multiple birth, early (before week 12) and late (weeks 12-28) miscarriage, stillbirth, and extrauterine pregnancy was compared to that of pregnancies ending in singleton birth. Furthermore, the distribution of th

First Record Of Soft-Shelled Turtles (Cryptodira, Trionychidae) From The Late Cretaceous Of Europe

Fossil soft-shelled turtles (Trionychidae) have so far been recognized in all continents except Antarctica, based largely on remains preserving their diagnostic sculptured shell bones. The origin of the group is generally assumed to be in the Early Cretaceous of Asia, whereas they first appear in North America and Europe during the Late Cretaceous and Paleocene, respectively. Here we describe the

Risk of glaucoma in ocular hypertension with and without pseudoexfoliation.

Purpose: To compare glaucoma conversion rates in patients with ocular hypertension (OH) with and without pseudoexfoliation. Design: Cohort study, based on 32 918 screening participants. Participants and Controls: Ninety-eight patients with OH and pseudoexfoliation and 98 matched controls. Main Outcome Measure: Perimetric glaucoma conversion. Methods: A population-based glaucoma screening of elderl

On variation in Faroese verb placement

In this paper, we present and discuss results from an investigation of verb placement in modern Faroese in which we collected data from speakers from a number of different dialect areas in the Faroe Islands. Altogether we interviewed 54 informants (age 15 – 67, 29 women and 25 men). Therefore, our study not only investigates the geographical variation claimed to be present in Faroese with respect

When is a patient with heart failure adequately informed? A study of patients' knowledge of and attitudes toward medical information

OBJECTIVE: The primary aim was to explore patients' knowledge of heart failure and their attitudes toward medical information (prognostic information in particular) and to assess different patient-related factors that might hamper the improvement of patients' knowledge. Moreover, taking the data obtained into account, we analyzed ethical aspects of information disclosure to patients with heart fai

Named Entity Recognition for Short Text Messages

This paper describes a named entity recognition (NER) system for short text messages (SMS) running on a mobile platform. Most NER systems deal with text that is structured, formal, well written, with a good grammatical structure, and few spelling errors. SMS text messages lack these qualities and have instead a short-handed and mixed language studded with emoticons, which makes NER a challenge on

Long-term changes in vegetation and soil chemistry in a calcareous and sandy semi-natural grassland

Calcicole plant species are vulnerable to acidification and fertilization, caused by deposition and changes in land use, since they are adapted to nutrient-poor calcareous conditions. In this study we used vegetation data (vascular plants, bryophytes and lichens) from 1964 and 1985 and stored soil samples from 1966 to investigate long-term soil chemistry and vegetation changes in a semi-natural, s