Search results

Enolase-1 (Eno1) plays a critical role in regulating glucose metabolism; however, its specific impact on pancreatic islet β-cells remains elusive. This study aimed to provide a preliminary exploration of Eno1 function in pancreatic islet β-cells. The findings revealed that the expression of ENO1 mRNA in type 2 diabetes donors was significantly increased and positively correlated with HbA1C and neg

Several authors have described how the formalization of recent decades has steered doctoral education towards structured curricula, more managerial control and new models for supervision. Largely absent from these accounts, however, is if and how doctoral education has been affected by the concurrent changes in research governance, in particular by the ‘projectification’ of research. For this studSeveral authors have described how the formalization of recent decades has steered doctoral education towards structured curricula, more managerial control and new models for supervision. Largely absent from these accounts, however, is if and how doctoral education has been affected by the concurrent changes in research governance, in particular by the ‘projectification’ of research. For this stud

Creating typologies of forest owners is a common approach for analyzing and understanding heterogeneity in responses to forest policies and management practice uptake. While many forest owner typologies have been developed, only a few quantitative methods dominate the field with little information on how methodological choice affects outcomes. In this study we compare five methods for quantitative

Load demand in residential houses is a significant contributor to peak load problems experienced by utilities. The knowledge about demand variation in households is fairly limited as well as the use of various tools to analyze the demand. Many utilities have recently installed interval (hourly) metering at their residential customers. The availability of hourly data is a significant progress, howe

Leachate constitutes the main potential long-term environmental risk of landfill emissions. The EU landfill directive 1999/3 I/EC requires minimum monitoring during the active landfill life and the after-care phase. Due to time and resource limitations, monitoring of leachate quality is a compromise between information density and applicability. Samples from passively collected leachate are suspec

Most energy behaviour studies on households focus on the questions how and why we use energy and what can be done to lower energy consumption. Very few studies raise the question of when energy is used or examine the underlying explanations to load patterns. Due to economic and technical problems with electricity peak load, it is important to gain knowledge about how the load patterns of household

The pathophysiologic mechanisms in type 1 diabetes (T1DM) involve loss of islet β-cell secretory function caused by selective killing of these cells primarily by aggressive autoimmune responses involving both cellular and humoral immune pathways. Inflammatory cells heavily infiltrate pancreatic islets leading to insulitis where CD8+ T lymphocytes are thought to be responsible for selective and spec

Information on soil mineralogy is essential for weathering rate calculations. Quantitative mineralogical analyses are expensive and time-consuming, and thus indirect methods of determining the mineralogical composition are important, for example estimating the composition based on the elemental content in till (total concentrations), or based on information about the underlying bedrock. The minera

Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired beta cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D and explored the mechanisms by which they would do this. Scandinavian subjects followed for up to

Previous time-use research suggests that it is highly relevant for an occupational therapist to estimate time use and occupational engagement in order to understand some of the determinants of wellbeing for people with schizophrenia. This article describes the development and the testing of the psychometric properties of an instrument, Profiles of Occupational Engagement in people with Schizophren