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Background Care of old people with multimorbidity living at home is often fragmented with lack of coordination and information exchange between health care professionals, the elderly and their relatives. This paper describes the protocol of a randomised, controlled study, which aims to compare the efficacy of caring for older people with multimorbidity and three or more hospital admissions in the
Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequ
Given difficult conditions in different regions of the world, it is no wonder that people embark on journeys to regions where they may feel secure, seek refuge, be able to acquire a livelihood, as well as carry on a type of living. At the same time, when migrants arrive in a new country that they have hitherto never been to, there is an expectation that they will integrate into the host country’s
Research on priority-setting for research, development, and innovation (RDI) often does not take into account the many challenges associated with translating priorities into RDI programs and projects. Such implementation challenges are typically handled by RDI program officers at funding agencies i.e. those officers that manage RDI programs and projects. To address this challenge, this paper utili
Relevant to, and drawing from, a range of disciplines, the chapters in this collection show the diversity, and applicability, of research in Bayesian argumentation. Together, they form a challenge to philosophers versed in both the use and criticism of Bayesian models who have largely overlooked their potential in argumentation. Selected from contributions to a multidisciplinary workshop on the to
The breaking with regime logics is one of the key leverage points to enable a socio-technical transition. Understanding how, and under what conditions, this may happen is thus an important task for transition studies. Recent research on socio-technical regimes has shown that they may be less geographically bound than previously assumed. Regimes may instead be replicated and reinforced globally thr
The exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some currenThe exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some curren
Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes
The severity of lung disease in cystic fibrosis (CF) may be related to the type of mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and to environmental and immunological factors. Since pulmonary disease is the main determinant of morbidity and mortality in CF, it is important to identify factors that can explain and predict this variation. The aim of this longitudi
