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TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore gating is unknown. We studied purified human TRPA1 (hTRPA1) truncated proteins to gain insight into the temperature gating of hTRPA1. In patch-clamp bilayer recordings, ∆1-688 hTRPA1, without the N-terminal ankyrin repeat domain (N-ARD), wa

Sedan 2017 har elever erbjudits att välja elektroniska digitala instrument (EDI) som huvudinstrument på ett antal gymnasieskolor i Sverige. Studien syftar till att undersöka hur elever som har EDI som huvudinstrument på gymnasiet reflekterar kring det egna instrumentet, sin musikaliska identitet samt övning och utbildning i förhållande till EDI. Då forskning om EDI i skrivande stund befinner sig i

This study examines how firms acquired in leveraged buyouts (LBOs) by private equity (PE) firms manage financial stability during macroeconomic turbulence by using investment as proxy. In an LBO, the acquisition is typically financed with substantial debt, which is placed on the balance sheet of the target firm, resulting in high leverage. A staggered Difference-in-Differences design is employed u

Newspapers and media have always played a critical role in society and have come to shape the way we reflect and perceive news and societal issues. Journalists are conveyer of a message and act as a moderator to shape and set the agenda for the public opinion and the public discourse. This research paper examines the media portrayal of refugees from Ukraine and Syria through pictures. These confli

Complement component C3 is central to the complement system, a humoral effector mechanism of innate immune defense. When activated, C3 covalently binds to target particles, marking them for uptake and clearance by phagocytosis. We now show that C3 also exists within the cytosol where it interacts with ATG16L1, and is therefore involved in the intracellular clearance and recycling of material by ma

LSTM architectures (Hochreiter and Schmidhuber, 1997) have become standard to recognize named entities (NER) in text (Lample et al., 2016; Chiu and Nichols, 2016). Nonetheless, Zhang et al. (2015) recently proposed an approach based on fixed-size ordinally forgetting encoding (FOFE) to translate variable-length contexts into fixed-length features. This encoding method can be used with feed-forward

Resection of advanced rectal cancer might result in significant tissue loss, including pelvic floor and parts of the vaginal wall. Pelvic floor reconstruction using a musculocutaneous flap offers optimized healing abilities and the possibility of vaginal reconstruction. In Skåne University Hospital, two different flap techniques are used to reconstruct the perineum: the vertical rectus abdominis m

The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non-carriers under multiple physiological conditions with state-of-the-art stable isotope techniques. After an overnight fast, carriers had higher plasma β-hydroxyb

Involving older people through co-design has become increasingly attractive as an approach to develop technologies for them. However, less attention has been paid to the internal dynamics and localized socio-material arrangements that enact this method in practice. In this paper, we show how the outcomes that can be achieved with user involvement often pertain to learning, but their content can di

Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. Here, we describe diabetes heterogeneity, highlighting recent approaches that could facilitate management by integrating three d