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Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney disease (DKD) in Type 1 diabetes (T1D) with replication in Type 1 and 2 diabetes. Sequencing reproducibly s
Research shows that young people within ethnic minorities are subjected to police control more often than others, which seems to have a damaging effect on their trust in the police as well as on their wider sense of belonging. What is less often researched is how these young people deal with being over-policed. This article explores narratives of over-policing from those targeted by the police in Research shows that young people within ethnic minorities are subjected to police control more often than others, which seems to have a damaging effect on their trust in the police as well as on their wider sense of belonging. What is less often researched is how these young people deal with being over-policed. This article explores narratives of over-policing from those targeted by the police in
This paper discusses the medieval castle and town Sölvesborg in Blekinge. It was a typical motte and bailey castle consisting of a huge brick tower built on an artificial mound surrounded by an inner moat and a large outer bailey. The castle, which was partly excavated in the 1940’s, 1970’s and in the 2010’s, functioned as the royal Danish castle that controlled Blekinge in the Middle Ages. It has
Social visions to replace fossil fuels with renewable energy sources have motivated unprecedented growth in global renewable energy manufacturing. Previous literature shows that people committed to realizing such visions have difficulties reconciling with the negative social-ecological impacts of this mass production even if it presents a formidable challenge to a socially just and ecologically su
Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 re
Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-ge
Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the e
Preclinical and genetic studies suggest that impaired glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling worsens glycemic control. The relationship between GIPR signaling and the risk of cancers influenced by impaired glucose homeostasis is unclear. We examined the association of a variant in GIPR, rs1800437 (E354Q), shown to impair long-term GIPR signaling and lower circulatin
Humans, like other animals, have a tendency to preferentially learn and retain some associations more readily than others. In humans, preferential learning was originally demonstrated for certain evolutionary prepared stimuli, such as snakes and angry faces and later extended to human social out-groups based on race (Olsson et al., 2005). To address the generality of this social learning bias, we
Renovations of the housing rental stock have become a political concern since they have been claimed to drive gentrification and affect tenants’ everyday lives as well as long-term housing conditions. Furthermore, new actors have entered the market, partly as a result of high supply on the international capital markets creating a flow of capital into market segments. This has led to a critique of
Metabolic dysfunction-associated steatotic liver disease (MASLD) is often asymptomatic early on but can progress to irreversible conditions like cirrhosis. Due to limited access to human liver biopsies, systematic and integrative molecular resources remain scarce. In this study, we performed transcriptomic analyses on liver and metabolomic analyses on liver and plasma samples from morbidly obese i
The Nordic welfare model is known for universalism, egalitarianism, and public responsibility. Integral to this is the “media welfare state”, in which the media supports democratic participation and welfare ideals. Yet globalization, demographic shifts, and digitalization are challenging these foundations, prompting questions about the media’s evolving role. This article explores how Nordic newspa
The endothelin receptor antagonist atrasentan improved kidney outcomes in the SONAR trial for type 2 diabetes and chronic kidney disease (NCT01858532), though individual responses varied. To identify molecular biomarkers of atrasentan response and outcome, we conducted a nested case-control proteomics study (N = 180) within the SONAR trial population and identified urinary clusterin (uCLU) as the
The great tit Parus major is known for its wide range of innovative foraging behaviours, which have enabled adaptation to anthropogenic habitats such as gardens and city parks. Some of the behaviours are general and common whereas others are rare and seem to have been invented and used by single birds. Here we report on a male great tit that specialised in capturing large butterflies that were for
