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Resection of advanced rectal cancer might result in significant tissue loss, including pelvic floor and parts of the vaginal wall. Pelvic floor reconstruction using a musculocutaneous flap offers optimized healing abilities and the possibility of vaginal reconstruction. In Skåne University Hospital, two different flap techniques are used to reconstruct the perineum: the vertical rectus abdominis m

The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non-carriers under multiple physiological conditions with state-of-the-art stable isotope techniques. After an overnight fast, carriers had higher plasma β-hydroxyb

Involving older people through co-design has become increasingly attractive as an approach to develop technologies for them. However, less attention has been paid to the internal dynamics and localized socio-material arrangements that enact this method in practice. In this paper, we show how the outcomes that can be achieved with user involvement often pertain to learning, but their content can di

Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. Here, we describe diabetes heterogeneity, highlighting recent approaches that could facilitate management by integrating three d

This paper analyzes incomes and income inequality in Stockholm from 1870 to 1970. The paper builds on a new dataset of 38,022 randomly sampled Stockholm residents 1870–1950, with information on income, occupation, age, gender, and household composition. This is complemented by the Census of 1930 and a Statistics Sweden sample for 1960 and 1970. Incomes were very unequally distributed between 1870

We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic re

The division between rural and urban values and practices is a classic theme in disciplines such as European ethnology. During the last decades, the urban/rural divide seem to be renegotiated. Traditional, small scale agriculture and food production encapsulates values on display at many dinner tables of the upper middle urban class. This has lead to new business opportunities for rural actors, of

Cells have an incredible ability to physically interact with neighboring cells and their environment. They can detect and respond to mechanical forces by converting mechanical stimuli into biochemical signals in a process known as mechanotransduction. This is a key process for the adaption of vascular smooth muscle and endothelial cells to altered flow and pressure conditions. Mechanical stimuli,

Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of which react with type-II collagen (COL2) in articular cartilage. We previously described a subset of COL2 antibodies targeting the F4 epitope (ERGLKGHRGFT) that could be regulatory. Here, using phage display, we developed recombinant antibodies against this epitope and examined the underlying mechanism of acti

Significant progress has been made in elucidating genetic risk factors influencing Type 1 diabetes (T1D); however, features other than genetic variants that initiate and/or accelerate islet autoimmunity that lead to the development of clinical T1D remain largely unknown. We hypothesized that genetic and environmental risk factors can both contribute to T1D through dynamic alterations of molecular

Although very few people appear to travel to the Nordic region in contexts that might accurately be described as ‘climate-related,' some Nordic states have developed bespoke legal provisions, and all have ‘exceptional grounds’ categories that may be applied when people seek to enter or remain in the context of climate change or disaster. This chapter provides a brief overview of legal provisions r

Research on inclusive place branding has primarily focused on residents, while tourists are yet to be addressed, except in representation studies. Inclusion is, however, more than a matter of representation. It must also consider the needs of the tourists. This study explores people with foreign backgrounds' anticipated constraints to domestic tourism. This article advances knowledge of inclusive

The activities of cluster initiatives operating as systemic intermediaries and supporting networking activities have been discussed in prior studies. We integrate insights from the cluster theory and the literature on sustainability transitions to study the activities of clusters acting as systemic intermediaries in the different phases of the development of a forest-based bioeconomy, namely (1) p

Intra-islet crosstalk has become a focus area to fully understand the regulation of insulin secretion and impaired β-cell function in type 2 diabetes (T2D). Here, we put forward evidence for insulin-like growth factor binding protein 7 (IGFBP7) as a potential protein involved in autocrine and paracrine β-cell regulation. We showed presence of IGFBP7 in granules of both human α- and β-cells and mea