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BACKGROUND: Increased aortic stiffness (arteriosclerosis) is associated with early vascular aging independent of age and sex. The underlying mechanisms of early vascular aging remain largely unexplored in the general population. We aimed to investigate the plasma metabolomic profile in aortic stiffness (vascular aging) and associated risk of incident cardiovascular disease and mortality.METHODS AN

Background: The body mass index (BMI) is prone to misclassification of obesity due to age-related height loss and resulting measurement errors. Knee-height based BMI (KH-BMI) has not been previously studied in relation to mortality risk in older adults. Aim: To evaluate the age- and sex-specific mortality risk relationship using classic BMI and knee height predicted BMI (KH-BMI) overweight and obe

Background ST-elevation myocardial infarction (STEMI) occurs as a result of rupture of an atherosclerotic plaque in the coronary arteries. Limited data exist regarding the impact of culprit coronary vessel on hard clinical event rates. This study investigated the impact of culprit vessel on outcomes after primary percutaneous coronary intervention (PCI) of STEMI.Methods A total of 29 832 previousl

Essentials Knowledge of genetic regulators of plasma factor VII activating protease (FSAP) levels is limited. We performed a genome-wide analysis of variants influencing FSAP activity in Scandinavian cohorts. We replicated an association for Marburg-1 and identified an association for a HABP2 stop variant. We identified a novel locus near ADCY2 as a potential additional regulator of FSAP activity.

Krita-paleogen-gränsen har länge varit central i diskussioner mellan forskare runt om i världen, då den markerar/sammanfaller med utdöendet av 75% av jordens arter till följd av ett enormt asteriodnedslag på Chicxulúbhalvön i Mexiko. Gränsintervallet är vida utbrett i sedimentära lagerföljder som bildades under denna tid, och kan identifieras genom sina unika kemiska egenskaper och karakteristiskaThe Cretaceous-Paleogene boundary has long been a center of discussion amongst scientists as it marks the extinction of 75% of all species on Earth. This mass extinction event was probably caused by an enormous asteroid impact event in what is now Mexico. The boundary interval is easily identified in the sedimentary geological record because of its unique chemical properties as well as its charact

Förekomsten av juridiskt oskolade som ett inslag i den dömande verksamheten, är ett fenomen som existerar världen över. I Sverige har institutionen med s.k. nämndemän länge varit en del av rättssystemet. Dess rötter härstammar från det medeltida samhället, men systemet har under åren modifierats flertalet gånger och inflytandet på rättskipningen har varierat. Det huvudsakliga syftet och dess vikti

Den här uppsatsen behandlar det upphovsrättsliga skyddet för musikaliska verk. Uppsatsen syftar till att utreda digitaliseringens påverkan av det upphovsrättsliga skyddet för musikaliska verk samt att utreda var gränsen går upphovsrättsligt mellan inspiration och plagiat i förhållande till musikaliska verk. Artister och musiker inspireras ständigt av varandra men det är inte självklart var gränsenThis essay deals with the copyright protection of musical works. The essay aims to investigate the influence of digitalization on the copyright protection of musical works and to investigate the legal boundary between inspiration and plagiarism in relation to musical works. Artists and musicians are constantly inspired by each other, but it is not obvious where the legal boundary goes between insp

I Sverige finns ett grundlagsstadgat skydd mot påtvingade kroppsliga ingrepp som omfattar i princip alla ingrepp som görs i hälso- och sjukvård. Det innebär att all hälso- och sjukvård måste ges med patientens samtycke eller med stöd i tvångslagstiftning. I dagsläget finns ingen möjlighet att ge vård till en patient som saknar kapacitet att lämna ett giltigt samtycke om inte tvångslagstiftningen ä

Objective: The primary aim was to relate Toxoplasma gondii seropositivity and serointensity to scores on the self-rated Suicide Assessment Scale (SUAS-S). Another aim was to reevaluate the previously reported positive association between T gondii serointensity and a history of nonfatal suicidal self-directed violence. Method: This cross-sectional, observational study compared T gondii serointensit

AIMS/HYPOTHESIS: Voltage-gated calcium channels of the L-type have been shown to be essential for rodent pancreatic beta cell function, but data about their presence and regulation in humans are incomplete. We therefore sought to elucidate which L-type channel isoform is functionally important and its association with inherited diabetes-related phenotypes. METHODS: Beta cells of human islets from

The global company operates from a number of locations worldwide, which entails geographical distances and logistical implications for product and parts transported, as well as the choice of product variety because of numerable worldwide consumer preferences. In these companies, packaging becomes a frequently used object to complement product features and achieve an effective and efficient means o

Background: To offer minimized risk-adapted adjuvant treatment on a community and nationwide basis for patients with clinical stage 1 (CS1) nonseminomatous germ-cell testicular cancer (NSGCT). The aim was to reduce the risk of relapse and thereby reducing the need of later salvage chemotherapy while maintaining a high cure rate. Patients and methods: From July 1995 to January 1998, a total of 232