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Acrylate contact allergy has been frequently reported since the 1970s, with hundreds of articles published in dermatology journals so far. The purpose of this thesis was to investigate the frequency of contact allergy to acrylates / methacrylates in patients with exposure to industrial, dental and nail uses of these substances. We also aimed to investigate the clinical and chemical aspects of pa
The overall aim of this thesis was to contribute to the development of new instruments for use in work rehabilitation contexts and to investigate whether clients’ perceptions of their work environment changed while participating in a work rehabilitation programme, as well as how they perceived the programme. The work rehabilitation in focus was the Redesigning Daily Occupations (ReDO) programme. T
Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).
Retinal ischaemia resulting from e.g. diabetes, vein thrombosis or arterial occlusion, is one of the major causes of visual impairment and blindness. Although new methods of treatment are being developed, there is still a need for more effective pharmacological forms of treatment. The aim of this work was to develop an appropriate animal model of retinal ischaemia in which the intracellular signal
Diets high in fibre have previously been associated with decreased risk of breast cancer in the Malmö Diet and Cancer cohort. Several potent compounds may exist in high-fibre diets that might protect against breast cancer, for example lignans. Plant lignans are converted to enterolactone by the gut microflora and are similar in structure to estrogens. Enterolactone may interact with the estrogen r
Neurotensin is released from the gut after fat intake and has a role in appetite regulations. Proneurotensin is a stable fragment of the neurotensin precursor hormone and fasting plasma proneurotensin levels have shown to be significantly associated with the development of cardiovascular disease in middle aged participants of the Malmö Diet and Cancer Study. Here, we aimed at replicating the initi
The aim was to evaluate first trimester nuchal translucency (NT) measurement for detection and risk assessment of fetal malformations and fetal loss. 39 572 pregnant women were randomised to either a routine ultrasound scan at 12-14 weeks including NT measurement or to a routine scan at 18-20 weeks. Prenatal diagnosis of major congenital heart malformations was compared between the two groups. In
Adipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. Protein kinase B (PKB) and phosphodiesterase 3B (PDE3B) are both phosphorylated and acti
The object of this study was to try to comprehend, how the rehabilitaion of individuals towards employment and beeing able to earn their own living, could be facilitated through co-operative actions from the concerned local authorities. This comprehension was founded on the narratives from individuals, about their needs and qualifications. In order to reach this object, I interviewed participants
I svensk rättsteori beskrivs en otydlighet i den rättsdogmatiska metoden när det kommer till valet av tolkningsmetod och enhetlig argumentationsteknik. Syftet med denna uppsats är att undersöka hur detta problem får sin lösning i praktiken. Detta görs genom en kvalitativ empirisk undersökning av 43 skadeståndsrättsliga mål från Högsta domstolen från 2013 till 2017. Undersökningen fokuserar på meto
Syftet med uppsatsen är att med en textsociologisk analys undersöka vilka tidskrifter och tidningar som finns i Carlskrona Läsesällskap (1794-1863), Åbo Läsesällskap (1798-1823) och Lunds Akademiska Läsesällskap (1812-1831), samt att undersöka orsakerna till läsesällskapens försvinnande. Inledningsvis beskrivs vad som är karaktäristiskt med den här typen av läsesällskap. För att nå målet med studi
This thesis, drawing from several empirical investigations, reaches the conclusion that there seems to be a positive correlation between the level of democracy and the level of state capacity in Latin American countries. This correlation is explained by a hypothesis derived from Rational Choice theory. With some important caveats, this conclusion is then applied to the discussion about democracy a
Populärvetenskaplig sammanattning: Syftet med detta arbete är att dels försöka finna dygnsvariationer i koncentrationen av fina aerosoler, dels att försöka förklara vad dessa kan bero på i den mån det är möjligt. Syftet inkluderar även att undersöka aerosolernas långväga transporter för att härigenom ta reda på varifrån partiklarna kommer ur ett regionalt perspektiv. För att lösa uppgiften utnyttj
