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Diabetes mellitus invariably involves impaired regulation of insulin secretion from pancreatic β cells, as a result of unfavourable environmental influences in combination with aberrant expression of risk genes at either the transcriptional or the translational level. A recent report in Nature Metabolism explores a novel role of mRNA methylation in β-cell function and suggests that its downregulat

Partial wh-movement does not exist in the modern Scandinavian languages. It is however found in Old West Scandinavian texts, but not in Old East Scandinavian texts. In this article it is argued that there is a correspondence between attested partial wh-movement and the possibility of deleting the complementizer corresponding to English that. Although complementizer deletion is possible in all mode

Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.

The intensification of agriculture during the second half of the twentieth century, has caused sever declines of farmland biodiversity, where loss of semi-natural habitats is one of the major drivers. To halt further loss of habitat and biodiversity, agri-environmental schemes (AES) are used to compensate farmers to use methods less harmful to the environment. In this thesis, I have investigated t

Popular Abstract in English Plants harvest sunlight to fix air carbon dioxide into a form which is the fundamental source of energy for other organisms such as animals. The domestication of crop plants and traditional breeding practices has resulted in increased yield and nutritional value of crops. This comes at a cost of loss in genetic variability that is required by living organisms to adapt tPotato is one of the major food crops and its yield is severely affected by late blight disease caused by Phytophthora infestans. P. infestans has the ability to manipulate plant defence signalling by secreting effector molecules causing so called effector triggered susceptibility. Some plants can recognize these effectors via resistance proteins that reactivate plant defence and lead to effector

Treatment with IgG against the malondialdehyde (MDA)-modified apolipoprotein B-100 epitope p45 reduces atherosclerosis in experimental models. This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease.

Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large studies. We asked whether expanding an established 27-variant GRS (GRS27) to a 50-variant GRS (GRS50) improved CHD prediction and whether GRSs are independent of self-reported family history of CHD.

Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW.

The conflicts concerning the preservation or destruction of the deserted church of Mårup in Denmark is followed from the the moment in 1928, when the church became redundant, untill 2004. The protection of the church is in conflict with the protection of the eroding cliff, the church as a symbol in conflict with the church as a source material, and the local people in conflict with central authori