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The etiology of type 1 diabetes foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of type 1 diabetes. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) and ZnT8 transporter (ZnT8A) allowed children to be followed from birth until the appearance of a first islet auto

Background Population-based studies have indicated an increase in bone turnover in hyperthyroidism with a subsequent decrease in bone mineral density and an increased risk of fractures, especially in postmenopausal women. However, heterogeneity between studies prevents a definitive conclusion. Graves' disease (GD) is an autoimmune disease, and it is the most common cause of hyperthyroidism. The ai

Background Intravesical recurrence (IVR) after surgery for upper tract urothelial carcinoma (UTUC) is a clinical problem. We investigated if preoperative invasive diagnostic modalities (IDM) such as antegrade/retrograde uretero-pyelography and/or selective urine cytology/barbotage, and URS with or without concomitant biopsy are associated with IVR after radical surgery for UTUC. Risk of death from

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat,

Focusing on the case of disability, this book examines what happens when previously marginalised individuals obtain the legal recognition of their equal citizenship rights but cannot fully enjoy these rights because of structural inequality.Bringing together disability and citizenship studies, it explores an original conceptualisation of disability as a distinct social division and approaches citi

In post-industrial society, creativity has become a universal remedy for a range of societal challenges. Policymakers increasingly design policies where the notion of creativity is central. This chapter takes a closer look at how policymakers seek to facilitate creative work, and why policy related to creative work assumes the form it does. The chapter draws empirically from a longitudinal study o

På 1960- och 70-talet var det vanligt att svenska damtidningar hade särskilda avdelningar för hemsömnad av kläder. I en tid då konfektion var dyrt hade sy själv-sidorna en viktig funktion i konkurrensen om de kvinnliga läsarna. Tonåringar läste tidningarna i jakt på modeller att kopiera för att kunna klä sig enligt det senaste modet. Trots betydelsen av sådana specialavdelningar har de endast fåttIn the 1960s and 1970s, many women’s magazines had special sections for home dressmaking. At a time when ready-to-wear clothing was expensive, the sew-it-yourself pages had an important function to win over competition among female readers. Teenagers read the magazines in search of clothing designs to copy in order to dress according to the latest fashion. Despite the importance of such special se

How to include knowledge and actors from local and regional levels like small-scale fishers and their communities in overarching governance frameworks? This is a pertinent question for ongoing Blue Economy processes, as highlighted e.g., in the Manifesto from the 2021 MARE conference. In an ongoing “from research to practice” project, we investigate how to include local and regional perspectives a

Neutrophils are our most numerous and deadly white blood cells and without them we would succumb quickly to infections by pathogens. The main mechanism that the neutrophils employ for our protection is phagocytosis, where they eat and enclose their target inside a membrane-bound organelle, the phagosome. Neutrophil phagosomes are highly dynamic entities, and a large amount of antimicrobial substan

Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. The 5-year survival rate for patients with limited disease is around 20% while it is