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BACKGROUND: Recent reports have shown that, although rare, findings of mucosal ulcers and perforations of the nasal septum in some cases may be associated with the use of topical nasal glucocorticosteroids (GCS). It can been speculated that, a reduction in septal mucosal blood flow causing ischemia may eventually induce septal perforations. AIM: To evaluate whether a single dose of a potent nasal
Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. SIV use CCR5 and rarely CXCR4 but may use other coreceptors as alternatives. We have studied vi
Some components of the below-ground carbon (C) cycle in terrestrial ecosystems are still poorly understood. A better understanding will be necessary to predict adequately the impacts of global change factors on C cycling and storage, especially in high-latitude ecosystems, where much of the C is stored below-ground. In this work some of the mechanisms of the below-ground C cycle in subarctic ecosy
Neuroblastoma is a childhood tumour derived from cells of the sympathetic nervous system, which are arrested at low differentiation stages. Low differentiation stage and high tumour stage correlate to poor outcome. In earlier studies we have found that hypoxia induces dedifferentiation of neuroblastoma cells, which implies that hypoxia evokes a more aggressive phenotype. Here we employ microarray
Infrared (IR) dryers are widely used in the paper industry, mainly in the production of coated paper grades. The thesis deals with various aspects of heat transfer and energy use in infrared heaters and dryers as employed in the paper industry. Both gas-fired and electric IR dryers are considered and compared. The thesis also provides an introduction to infrared heaters and infrared drying, includ
S. pneumoniae is a major cause of common diseases such as acute otitis media and pneumonia, as well as more serious illnesses like septicemia and meningitis. The increasing level of resistance in pneumococci threatens to change the tradition of treating common respiratory infections with narrow-spectrum penicillin. In the city of Malmö the proportion of penicillin nonsusceptible S. Pneumoniae (PNS
The aim of the current thesis was to investigate glial responses to electroconvulsive seizures (ECS), an animal model of the fast-acting antidepressant treatment electroconvulsive therapy (ECT). Depression, a common and devastating disorder, has in recent years been associated with volumetric changes in prefrontal cortex, hippocampus and amygdala, brain regions known to be implicated in emotional
Chronic skin ulcers are a major health problem and an increasing burden on health care providers. These ulcers have various underlying causes, such as venous or arterial insufficiency, diabetes, or vasculitis. Non-healing venous leg ulcers represent a condition characterized by excessive inflammation and presence of bacteria. The overall aim of this thesis has been to explore the pathogenesis of t
Atoms and molecules absorb and emit light at certain, welldefined wavelengths, and this forms the basis of spectroscopy. The wavelengths are given by the discrete energy levels of the atoms/molecules. When illuminated by light of a suitable wavelength, the light will be absorbed, making it possible to deduce information on the presence and concentration of various elements and compounds. When ato
The aim of this work was to get a more detailed basis for planning of local public transport. With more knowledge of how segments of travellers assess different parts of a journey, bus routes can be planned to fit either all passengers or selected groups better. It will also be possible to evaluate perceived travel utility separately for each category of passengers. Stated Preference questionnaire
