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The aim of this study was to evaluate the diagnostic potentials of four different biochemical markers, serum cobalamin, blood folate, plasma homocysteine and serum methylmalonic acid for diagnosis of cobalamin/folate deficiency in a psychogeriatric population. The second aim was to investigate the relationship between these markers and various clinical and functional parameters of the nervous syst
Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment modality presented here is immunotherapy, either alone or combined with in
Aim: The overall aim of this thesis was to generate further knowledge about prosthetic and orthotic services in developing countries. In particular, the thesis focused on patient mobility and satisfaction with prosthetic and orthotic devices, satisfaction with service delivery, and the views of staff regarding clinical practice and education. Methods: Questionnaires, including QUEST 2.0, were use
There is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. The indefinite expansion capacity of PSCs, combined with the possibility of creating these cells from patient-specific
Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children <4 years and adults >50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. In contrast to pediatric ALL, which has a favorable prognosis, adult ALL is associated with a much poorer outcome with less than 40% overall
The aims of this work were: 1) to estimate the number of follicles, ovarian volume and power Doppler vascular indices and their changes with age using three-dimensional (3D) transvaginal grey-scale and power Doppler ultrasound in asymptomatic women of fertile age either with natural menstrual cycles or using combined oral contraceptives, and 2) to determine whether tumour vascularity, assessed by
The topic of this thesis is model-based control of two combustion engine concepts, Homogeneous Charge Compression Ignition (HCCI) and Partially Premixed Combustion (PPC), using physics-based models. The studied combustion concepts hold promise of reducing the emission levels and fuel consumption of internal combustion engines. A cycle-to-cycle model of HCCI, including heat losses to the cylinder
Laser based optical diagnostic methods are routinely used in combustion research. Many of the more common approaches are based on illuminating a cross-section of the sample with a thin laser sheet. For example, by targeting an electronic transition in a molecule, its concentration within the plane illuminated by the laser sheet can be deduced. By probing the relative occurrence of an atom or molec
Sediment sequences from five lakes on the Skagi peninsula, northern Iceland, were subjected to mineral magnetic analysis, carbon analysis, pollen analysis, plant macrofossil analysis, diatom analysis, radiocarbon dating and tephra analysis in order to make detailed reconstructions of vegetation, climate and sea level during the Late Weichselian and Early Holocene. The main purpose was to investiga
The aim of this research was to clinically and experimentally evaluate the use of vacuum-assisted closure in poststernotomy mediastinitis after cardiac surgery. Vacuum-assisted closure (VAC) is a new wound-healing therapy based on the application of a local negative pressure to the wound. New techniques for treating poststernotomy mediastinitis are needed since conventional techniques have an unsa
The aim of this thesis was to study the morbidity and mortality of cardiovascular disease (CVD) in obese individuals, as measured by different obesity measurements, and to explore how the CVD risk related to obesity was modified by other biologic and socio-demographic circumstances. Data from two population-based cohort studies was used. The Malmö Preventive Project included 22 444 middle-aged me
The planning and design of street networks in cities influence driving behaviour and give rise to variations in driving patterns (i.e., speed and acceleration profiles) that affect exhaust emissions and fuel consumption. The primary objective of this study has been to use real-life driving patterns to investigate how the characteristics of street networks influence fuel consumption and vehicular e
Local anaesthetics provide excellent pain relief after central and peripheral nerve blocks. However, in many clinical situations there is an insufficient duration of action to allow effective treatment of long-term pain with single injection techniques. This problem became the focus of the present studies. The natives in South America used to chew the leaves from Erythroxylon Coca and were well aw
This dissertation comprises a corpus-based study of the form and function of sentential object complements in Modern Standard Arabic (MSA). The study is motivated by the scarcity of investigations into MSA syntax as opposed to the syntax of Classical Arabic. Complements to three classes of complement-taking predicates (CTPs) manipulation, cognition and utterance are considered. The major part
The overall aim of the thesis was to describe long-term development of functional outcomes in children with cerebral palsy undergoing selective dorsal rhizotomy (SDR) combined with physiotherapy and to evaluate measures used in follow-up. Five years after SDR muscle tone was reduced, passive range of motion (PROM) increased in hip, knee and foot, gross motor function measured by the Gross Motor F
Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, respectively. Variation in CAG repeat length had been associated with a number of andrological disorders, where
Abstract The epidermis is one of our primary interfaces towards the external milieu. Following injury, the physical barrier function of the skin is destroyed and the epidermis is left vulnerable to microbial invasion. Inducible innate immune response mechanisms exist to keep the wound site free from infection, thus allowing the wound to heal and the epidermis to re-establish its barrier function.
