Filetype
Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to
In this thesis, different optical methods utilising visible light for characterization of tissue have been developed and evaluated. The feasibility of many of these methods has been demonstrated in the laboratory or in animal experiments. However, the goal is naturally to develop methods useful in the clinic, and thus the emphasis in this thesis has been put on in vivo examinations. Raman spectro
Thumbelina is one of Hans Christian Andersen´s most well-known tales, found worldwide in a wealth of translations and many illustrative versions, featuring not only in printed forms but also as children´s theatre, animated films and – in the bicentenary year of 2005 – also as a ballet with scenography and costume by Her Majesty Margrethe II, Queen of Denmark. In Odense, Andersen´s native city, the
Children with severe diseases can be provided nutritional support through a gastrostomy if needed. At the Department of Paediatric Surgery in Lund we have used the Video Assisted Gastrostomy (VAG) procedure since 1994 when establishing gastrostomies. In this thesis, children with different diseases, who all had undergone the VAG procedure, were studied in five different clinical studies. Postopera
The adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. Rifabutin is a broad spectrum antibiotic with known ocular adverse effects (corneal opacities, uveitis and vascular ret
Anaerobic digestion of organic matter results in the production of biogas, which can be used to replace fossil fuels. There is potential for increased biogas production at wastewater treatment plants by digesting urban organic waste either separately or together with the sludge. Biogas production could also be increased by sludge pre-treatment. The objective of this work was to evaluate the poten
The idea of phosphorus removal at wastewater treatment plants is to transfer dissolved phosphorus into a solid phase. Together with the rest of the produced sludge it is then removed from the water, resulting in a decreased concentration of phosphorus in the effluent and the prevention of the eutrophication in the recipient. Phosphorus can either be stored biologically, with enhanced biological p
The overall aim of this prospective observational study with a salutogenic approach was to investigate bone mineral density (BMD) and BMD changes in the heel bone, in a group of healthy women, in relation to physiological factors and lifestyle behaviours over a two-year period as well as investigating the women’s view of their lifestyle behaviours. Data were collected in 1999 (T1) and 2001 (T2). H
This thesis addresses identification and intervention of language and communication problems in children. The issue of identification is addressed in study I by investigating communicative ability in 18-month-old children, and in study II by exploring the prevalence of language and communication problems in children with complex problems, such as attention deficit hyperactivity disorder (ADHD). Th
Allocation, control, and management of natural resources are issues that absorb researchers within both the social and natural sciences. This study deals with such research questions as well as with one of the most fundamental issues in Economic History – namely institutional change. The plot is set around continuity and change of property rights institutions governing water resources. The setting
The theory and practice of international relations are replete with dilemmas related to the distribution of responsibility for human rights protection. Institutionalized notions of public and private empower and shape knowledge of what the spheres of responsibility signify for different kinds of actors. This study examines how the public-private distinction is manifested in controversy concerning
Clinical cytology is a rapid method to detect malignancy in effusions of the serous cavities, but the morphological characteristics of the cells do not always allow diagnosis and a specific marker for malignant cells would improve the diagnostic performance. Telomerase adds telomere repeats to the chromosome ends. It is the most promising universal indicator of malignancy and the project focuses o
Hip fracture is the most serious and resource consuming consequence of osteoporosis. All patients need operation and hospital treatment which gives a great health economic impact. The two main types of hip fracture are cervical (femoral neck, intracapsular) and trochanteric (extra capsular). For the displaced cervical fractures the blood circulation to the femoral head is more or less damaged whic
Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest surface to the outside environment; it performs diverse and complex roles in an ever changing external
