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Background and aims. Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods. We evaluated in a prospective manner the tolerance

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Traditionally, occupational injury rates are measured as number of injuries per amount of work. In contrast, we propose that for certain purposes of economic policy, a more relevant measure could be obtained by considering them as production costs and comparing them with output. This was accomplished by replacing “hours worked” in the traditional formulae for estimating accident risk with “value a