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CD4+ T cells subsets have a wide range of important helper and regulatory functions in the immune system. Several studies have specifically suggested that circulating effector CD4+ T cells may play a direct role in control of HIV replication through cytolytic activity or autocrine β-chemokine production. However, it remains unclear whether effector CD4+ T cells expressing cytolytic molecules and β

Introduction: Synovial fibroblasts (S-Fib) are recognized as key drivers of joint inflammation in adult arthritis. Moreover, data are limited on the processes driving monocyte activation in oligoarticular juvenile idiopathic arthritis (oJIA). Therefore, we aimed to explore if S-Fib from patients with oJIA induce monocyte activation. Methods: S-Fib were isolated from the synovial fluid (SF) of n =

There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and

To investigate the frequency of isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) mutations in pediatric acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), we sequenced these genes in diagnostic samples from 515 patients (227 AMLs and 288 ALLs). Somatic IDH1/IDH2 mutations were rare in ALL (N=1), but were more common in AML, occurring in 3.5% (IDH1 N=3 and IDH2 N=5), with the frequency h

The epithelial cell adhesion molecule gene (EPCAM, previously known as TACSTD1 or TROP1) encodes a membrane-bound protein that is localized to the basolateral membrane of epithelial cells and is overexpressed in some tumors. Biallelic mutations in EPCAM cause congenital tufting enteropathy (CTE), which is a rare chronic diarrheal disorder presenting in infancy. Monoallelic deletions of the 3′ end

Porcine sapovirus is an enteric calicivirus in domestic pigs that belongs to the family Caliciviridae. Some porcine sapoviruses are genetically related to human caliciviruses, which has raised public health concerns over animal reservoirs and the potential cross-species transmission of sapoviruses. We report on the incidence, genetic diversity, and molecular epidemiology of sapoviruses detected in

BACKGROUND: Human B lymphocytes can produce leukotriene B4 but the biological function of the 5-lipoxygenase (5-LO) pathway in B cells is unclear. In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma.RESULTS: Based on RT-PCR and western blot/immun

Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis profoundly attenuates atherosclerosis. As CD40L exerts multiple functions depending on the cell-cell interactions involved, we sought to investigate the function of the most relevant CD40L-expressing cell types in atheroscleros

BACKGROUND: Antibody-based constructs for molecular imaging and therapeutic delivery provide promising opportunities for the diagnosis and treatment of atherosclerosis.OBJECTIVES: The authors aimed to generate and characterize immunoglobulin (Ig)G monoclonal autoantibodies in atherosclerosis for targeting of novel molecular determinants.METHODS: The authors created hybridomas from an unimmunized l

The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addi

Introduction: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods:We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of p

OBJECTIVE: This systematic scoping review aimed to map the literature on the use of various nudging strategies to influence prescriber behavior toward reducing opioid prescriptions across diverse healthcare settings.METHODS: A systematic database search was conducted using seven electronic databases. Only articles published in English were included. A total of 2234 articles were identified, 35 of

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated thrombocytopenia and variable phenotype as some patients suffer no bleeding whilst others have bleeding from mild to severe, which may be fatal. This variability probably reflects the disease's complex pathophysiology; a dysregulated hyperreactive immune effector cell response involving the entire adaptive immune s

Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7083 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ Documenting Determinants of the Divorce Transition. Micro-Level Evidence from Sweden 1905–1967 MARTIN BERGVALL, MARIA STANFORS LUND PAPERS IN ECONOMIC DEMOGRAPHY 2022:3 Documenting Determinants of the Divorce Transition. M

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-01/LPED%202022%203.pdf - 2026-07-25

Thesis Stephen.PDF Lund’s University Master’s Programme in Environmental Science P.O. Box 170, S-22100, Lund, Sweden TEL:+46-(0)46-222-04-70 Can FORECAST be used to predict the Sustainability of Norway Spruce Stands in Southern Sweden? Master’s Thesis Submitted January 31, 2001 Supervisor: Patrik Wallman Doctoral Student, Chemical Engineering II P.O. Box 124; SE-221 00 Lund, Sweden Tel: +46 (0)46

https://www.lumes.lu.se/sites/lumes.lu.se/files/burke_stephen.pdf - 2026-07-25

Microsoft Word - Thesis, 2011-06-01 (statiska referenser).docx                               Scouting  for  Sustainable  Development   A  study  of  some  young  people’s  environmental  views  within  the   Scout  Movement               By:     Lovisa  Lönegren   lovisen@hotmail.com         Supervised  by:   Lena  Christensen   lena.christensen@lucsus.lu.se       Lund  University  Center  for  Su

https://www.lumes.lu.se/sites/lumes.lu.se/files/lonegren_lovisa_thesis_2011.pdf - 2026-07-25

Lund University Lund University Master's Programme in Environmental Science (LUMES) Master Thesis December 1998 Environmental Behaviour and Behaviour Change A study of Agenda 21 in twelve municipalities Author: Malin Månsson Kulgränden 3 C:42 22649 LUND Phone: +46-46 12 8857 e-mail: env97mmn@student2.1u:.se Abstract The aim of the thesis is to study and analyse how municipalities in Sweden work to

https://www.lumes.lu.se/sites/lumes.lu.se/files/mansson_malin.pdf - 2026-07-25

Achieving a sustainable waste disposal system on municipal solid wastes by analysing and comparing major waste treatment ways LUMES – Lund University International Master’s Programme in Environmental Studies and Sustainability Science Controlling Municipal Solid Waste (MSW) Over-generation with a “Waste Disposal Fee” Based on an Efficient Stakeholder Partnership --a case study in the old city of N

https://www.lumes.lu.se/sites/lumes.lu.se/files/keer_chen.pdf - 2026-07-25

0 From water profiteers to distribution caretakers by Lucas Le Provost lucasleprovost@gmail.com for the degree of MASTER OF SCIENCE June 2010 A thesis submitted in partial fulfillment of the requirements of Lund University International Master’s Programme in Environmental Studies and Sustainability Science Thesis Supervisors Maryam Nastar PhD Student, LUCID Research School maryam.nastar@lucsus.lu.

https://www.lumes.lu.se/sites/lumes.lu.se/files/leprovost_lucas_thesis_2010.pdf - 2026-07-25

Microsoft Word - freight transport and the environment-final.doc Lund University International Master’s Programme in Environmental Science Freight Transport and the Environment. Environmental Impact of Increased Transportation due to Product Price Differences Master’s Thesis Prepared by Evelin Urbel Address: Kuldnoka 15-113, 10619 Tallinn Estonia Telephone: +372 656 44 23 Mobile: +372 56 478 858 E

https://www.lumes.lu.se/sites/lumes.lu.se/files/urbel_evelin.pdf - 2026-07-25