Filetype
Tissue immunity and responses to injury depend on the coordinated action and communication among physiological systems. Here, we show that, upon injury, adaptive responses to the microbiota directly promote sensory neuron regeneration. At homeostasis, tissue-resident commensal-specific T cells colocalize with sensory nerve fibers within the dermis, express a transcriptional program associated with
Objective: To investigate cellular immune responses to the herpes zoster (HZ) subunit (HZ/su) vaccine in patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKis). Methods: RA patients treated with JAKi (n=46) at the Department of Rheumatology, Skåne University Hospital, Sweden, and healthy controls (n=37) received two doses of the HZ/su vaccine. Blood samples were colle
During the epidemic neuropathy occurred in Cuba from 1992 to 1993, viral isolations antigenically connected with Coxsackie viruses were obtained from the cerebrospinal fluid of patients. Virological, epidemiological, toxicologic, nutritional, immunological and histopathological investigations were made. Though the disease was related to toxic and nutritional factors, it has been impossible to iden
The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is able to promote the generation of tolerogenic mature dendritic cells (mDCs) with an impaired ability to activate autoreactive T cells. These cells could represent a reliable tool for the promotion or restoration of Ag-specific tolerance through vaccination strategies, for example in type 1 diabetes patients. Howe
Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross
Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes and what they sense remain poorly defined. Here we demonstrate that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems. T
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life immune development, and the gut microbiota can impact host physiology in various ways, such as through the production of metabolites. However, few breastmilk-dependent microbial metabolites mediating host–microbiota interactions are currently known. Here, we demonstrate that breastmilk-promoted Bifidobacter
The intestinal lamina propria contains a diverse network of fibroblasts that provide key support functions to cells within their local environment. Despite this, our understanding of the diversity, location and ontogeny of fibroblasts within and along the length of the intestine remains incomplete. Here we show that the small and large intestinal lamina propria contain similar fibroblast subsets t
High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generall
Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To address this unmet need, novel pharmacological targets must be identified for clinical inter
Objective: To develop a standardized sonographic evaluation and reporting system for Cesarean scar pregnancy (CSP) in the first trimester, for use by both general gynecology and expert clinics. Methods: A modified Delphi procedure was carried out, in which 28 international experts in obstetric and gynecological ultrasonography were invited to participate. Extensive experience in the use of ultraso
Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Met
Purpose: To examine [18F]RO948 retention in FTD, sampling the underlying protein pathology heterogeneity. Methods: A total of 61 individuals with FTD (n = 35), matched cases of AD (n = 13) and Aβ-negative cognitively unimpaired individuals (n = 13) underwent [18F]RO948PET and MRI. FTD included 21 behavioral variant FTD (bvFTD) cases, 11 symptomatic C9orf72 mutation carriers, one patient with non-g
The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a nove
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder involving scarring of pulmonary tissue and a subsequent decrease in respiratory capacity, ultimately resulting in death. Tartrate resistant acid phosphatase 5 (ACP5) plays a role in IPF but the exact mechanisms are yet to be elucidated. In this study, we have utilized various perturbations of the bleomycin mouse model of IPF includ
Bioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses great challenges. While implanted rigid and substrate-bound electrodes often result in inflammation and scarring in vivo, they outperform the in situ-formed, more biocompatible electrodes by providing superior control over electrode geometry. For example, one of the most researched met
B lymphopoiesis is orchestrated by lineage-specific transcription factors. In B cell progenitors, lineage commitment is mediated by Pax5, which is commonly mutated in B cell acute lymphoblastic leukemia. Despite its essential role in immunity, the mechanisms regulating Pax5 function remain largely unknown. Here, we found that the NAD+-dependent enzyme SIRT7 coordinates B cell development through d
Slutrapport LUDICH Layout 21 Jan LL Projektrapport 1 LUDICH: Lund University Digital Interactive Concert Hall Tematiskt samverkansinitiativ Slutrapport Datum 2025-12-31 Konstnärliga fakulteten, kansli Jesper Larsson, Expert och projektledare Postadress Box 117, 221 00 Lund Besöksadress Arkeologen, Sandgatan 1, Lund Telefon 046-222 00 00 E-post projektkontoret@rektor.lu.se Webbadress https://www.lu
https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2026-04/Slutrapport%20LUDICH.pdf - 2026-07-25
1.0 Østdanmark til Sverige DA ØSTDANMARK BLEV SYDSVERIGE DA ØSTDANMARK BLEV SYDSVERIGE Otte studier i dansk-svenske relationer i 1600-tallet Redigeret af Karl-Erik Frandsen & Jens Chr.V. Johansen Skippershoved Skånsk Senmedeltid och Renässans Skriftserie utgiven av Vetenskaps-Societeten i Lund nr. 19 DA ØSTDANMARK BLEV SYDSVERIGE © Forfatterne og Skippershoved 2003 Redaktion: Karl-Erik Frandsen &
https://www.cors.lu.se/sites/cors.lu.se/files/ostdanmarkboken.pdf - 2026-07-25
Stress, Over-consumption and Climate Change Can humans manage climate change if social norms would include the significance of attachment, altruism, long term global thinking and local action? by Annika Tibblin symbolica.tibblin@gmail.com MASTER OF SUSTAINABLE AND ENVIRONMENTAL SCIENCE May 2008 A Thesis Submitted to Lund University in partial fulfilment of the requirements for the degree Lund Univ
https://www.lumes.lu.se/sites/lumes.lu.se/files/annika_tibblin.pdf - 2026-07-25
