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BACKGROUND: Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. The aims of the study were to determine age and gender specific nor
The article presents an analytical model for evaluation of ion angular distribution functions (IADFs) at a radio frequency (rf)-biased surface in a high-density plasma reactor. The model couples a unified rf sheath model to an assumed ion velocity distribution function-based formulation for determining the IADF under any general rf-bias condition. Under direct-current (dc) bias conditions the IADF
Background. Goodpasture's disease (GP) is a rare but severe disease characterized by anti-glomerular basement membrane antibodies, rapidly progressive glomerulonephritis and lung haemorrhage. The autoantibodies are restricted to a narrow epitope region on the NC1 domain of the alpha3 chain of type IV collagen. GP is strongly associated with major histocompatibility complex (MHC) allele HLA DRB1-15
We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, overweight and obese individuals.We investigated the association of genetic scores with euglycaemic-hyperinsulinaemic clamp- and OGTT-based measures of insulin resistance and secreti
Popular Abstract in Swedish Astma och hösnuva (allergisk rinit) är två närbesläktade sjukdomar som båda har sin grund i en långdragen, kronisk inflammation i luftvägsslemhinnan. Vid både astma och hösnuva har slemhinnan en benägenhet att reagera kraftigare än normalt på retningar (s.k. hyperreaktivitet). Inflammationen och hyperreaktiviteten regleras av hundratals olika signalsubstanser (mediatoreMucosal inflammation and airway hyperreactivity are regulated by hundreds of different mediators. The recent discovery of gaseous mediators, produced and active within the airways, opens new possibilities for identification of therapeutic targets and ways to monitor airway inflammation. This thesis is focused on two such mediators, nitric oxide (NO) and carbon monoxide (CO) along with their role i
Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone. Based on results obtained from in vitro experiments, the protein was shown to bind osteoblasts via the integrin receptor alpha(v)beta(3). Due to OSAD's capacity to bind hydroxyapatite crystals, a role for the protein in the mineralization process has also been suggested. To test these hypotheses in an
Objectives: It has been well established that male erectile dysfunction is frequently associated with vascular diseases. The normal function of cavernous arteries is considered a prerequisite to maintain sufficient blood flow to the trabecular spaces in order to enable penile erection. Contractility of cavernous arteries is regulated by the peripheral autonomic nervous system and endogenous factor
Background: Large-scale data on type-specific HPV prevalences and disease burden are needed to monitor the impact of HPV vaccination and to plan for HPV-based cervical screening. Methods: 33 043 women (aged 25-65) were screened for HPV by a Hybrid Capture 2 (HC2) in a population-based programme. HPV-positive women (n = 2574) were triaged by cytology and HPV genotyped using PCR-Luminex. Type-specif
Aims: This work was carried out to investigate whether considering cartilage depth in vivo dGEMRIC would provide additional information on the molecular content and changes in normal and diseased cartilage. Methods: Study I was a longitudinal study on 23 healthy volunteers; Study II was a case-control study on 9 sedentary individuals and 8 elite runners. Study III was a longitudinal study on 30 p
Time-dependent distribution of extracellular proteins (albumin, fibrinogen, fibronectin, collagen-I and IgG) in the interface zone between implant and soft tissue has been investigated utilizing a recently developed method. Commercially pure (c.p.) titanium and polytetrafluoroethylene (PTFE) implants were inserted in the abdominal wall of rats for 1, 6 and 12 weeks followed by a mild fixation, cry
Background: Obesity and associated metabolic conditions impact adipocyte functionality with potential consequences for breast cancer risk and prognosis, but contributing mechanisms remain to be understood. The adipokine receptor adenylyl cyclase-associated protein-1 (CAP1) has been implicated in the progression of breast cancer, but results are conflicting and the underlying molecular mechanisms a
Prostatic acid phosphatase (PAP), prostate‐specific antigen (PSA), and β‐microseminoprotein (β‐MSP) were regularly localized immunohistochemically to the epithelium of the acini and that of the ducts in the nodules of 24 cases of benign prostatic hyperplasia. The immunohistochemical distribution of these three prostatic‐secreted proteins was also examined, with monoclonal antisera against PAP and
Study region: The NekooAbad Irrigation District in central Iran faces challenges due to inefficient surface water distribution. 82 million m3 of groundwater is extracted annually from 15,000 tube-wells, leading to decreased groundwater levels and increased energy consumption of 234 million kWh per year. Study focus: This study explores implementing automation in surface water distribution to reduc
The rat urinary bladder responded to infravesical obstruction by an increased weight. The weight began to increase after 3 days of obstruction. After 10 days the weight gain had become significant, but increased further with time. At 90 days the bladders weighed 12 times the initial weight. Lactate dehydrogenase (LDH) activity per unit bladder weight increased with the duration of the obstruction.
Popular Abstract in Swedish Geografisk fördelning av inomartsvariation i vittspridda Euroasiska skogsväxter Torbjörn Tyler Sammanfattning av författaren's doktorsavhandling Inledning Arter's utbredningar bestäm's inte bara av omvärldsfaktorer som klimat och jordmån utan även av de möjligheter det givit's dem att sprida sig. För att sprida sig över stora geografiska områden kräv's tid och i en väMany woodland plant species have huge distribution areas covering large parts of the Eurasian continent including areas that were glaciated during the last glacial period. In the present thesis, the geographic distribution of variation within such species is investigated and discussed in relation to glacial survival and post-glacial migration, dispersal ability, breeding system and levels of gene-
BACKGROUND: Ion channel transient receptor potential A1 (TRPA1) and cannabinoid (CB) receptors are involved in mechanoafferent signaling from the bladder and the urethra. OBJECTIVE: To characterize TRPA1-, CB1-, and CB2-receptor activities in the human prostate. DESIGN, SETTING, AND PARTICIPANTS: Prostate specimens were obtained from 12 patients undergoing radical prostatectomy. We studied express
Mechanisms involved in the islet adaptation to insulin resistance were examined in mice of the C57BL/6J strain challenged with a high-fat (58%) diet for 8 weeks. Basal hyperglycemia commenced after 1 week, whereas hyperinsulinemia evolved after 8 weeks. Glucose elimination after an intravenous glucose challenge (1 g/kg) was significantly delayed after 1, 4, and 8 weeks on the high-fat diet compare
AimDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.MethodsAntiDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an
Här studeras konceptet ’zero waste’, ungefär ’inget avfall’, applicerat på livsmedelsindustrin, och hur den miljömässiga påverkan skiljer sig mellan ett förpackningslöst scenario som kan ses i en nischad, dansk livsmedelsbutik, och ett konventionellt scenario, där två typiska produkter i vanliga matbutiker används som referenser. I den danska butiken säljs havregryn i gravitationsmatare (gravity dThis study investigates the zero-waste concept applied to the food industry, and how the environmental impact differs between a package-free scenario found at a specialised Danish retail-store and a conventional scenario, using two reference products typically found in normal retail stores in Sweden. In the Danish store, the oats are sold in gravity dispensers, and the rapeseed oil is sold in glas
