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In this study, the effect of pH (3–8), ionic strength (I, 0.01–1 M), protein particle concentration (C, 0.5%–2%), and dispersed phase volume fraction (Φ, 0.25–0.8) on the efficacy of hordein-based colloidal nanoparticles in the stabilization of Pickering structures was investigated. Colloidal particles were synthesized via anti-solvent method. Depending on pH and I, the average size and zeta-poten
We strive for a detailed understanding of the interactions between cells and nanostructures with respect to cell behavior, cell physiology and cell mechanics. This knowledge allows us to develop novel nanoscale devices with applications in biology and medicine, such as: - the development of nanowire devices that can interact with cells with minimal cell perturbation (e.g. for injection, nanobiopsy
https://www.nano.lu.se/research/life-science-nano/nanobio-interactions-and-applications - 2026-10-03
Inom fysiken används ofta hårda sfärer som modellsystem för att beskriva beteenden och strukturer hos grundläggande byggstenar såsom atomer och molekyler. Dessa sfärer kan ses som en samling biljardbollar och kan därav bara organiseras på ett begränsat antal sätt. Med den ökade förståelsen för många komplexa fysikaliska fenomen och den snabbt växande utvecklingen av nya material behövs modellsysteSoft and deformable ionic microgels such as poly(N-isopropylacrylamide-co-acrylic acid), PNIPAM-co-AA, microgels have shown to be a versatile alternative to the already well-established hard sphere model systems. Their tuneable interaction potential makes them well suited as model systems to study the phase behaviour found for particles interacting via a soft isotropic potential. This stems from t
High quality salmon smolts are essential for aquaculture, enhancement programs and wild populations. However, intensification of aquaculture smolt production and changes in natural habitats can cause sub-optimal environmental conditions, which may result in poor smolt quality. The salmon brain, as the integrator of environmental information, plays a focal role in relaying this information through
We investigated the water sorption properties of macroporous cryogels of gelatine (Gel) and dextran dialdehyde (DDA) prepared via cryogelation at 260 K and following the freeze drying processes. Water vapour sorption isotherms for aerogels were studied at 293 K by two inde-pendent methods: static-gravimetric and dynamic vapour sorption (DVS) over a water activity range of 0.11–1.0. Experimental da
The use of dental implants to treat tooth loss has increased rapidly over recent years. 'Smooth' implants showing high long-term success rates have successively been replaced by implants with rougher surfaces, designed to stimulate rapid osseointegration and promote tissue healing. If exposed in the oral cavity, rougher surfaces may promote bacterial adhesion leading to formation of microbial biof
Background: Peritonitis is the leading cause of morbidity for peritoneal dialysis (PD) patients, and microbial biofilms have previously been identified on catheters from infected patients. However, few studies of catheters from patients without clinical signs of infection have been undertaken. The aim of the present study was to investigate the extent to which bacteria are present on catheters fro
Whey protein powder functionality is expected to be closely linked to both structure and properties of the proteins. It is essential that whey protein powders are easily dispersed and dissolved in order to fulfil the specified nutrient content and the functionality in the final product. Poor rehydration can cause challenges on an industrial level as well as for the consumers. In this thesis, severWhey protein powder functionality is expected to be closely linked to both structure and properties of the proteins. It is essential that whey protein powders are easily dispersed and dissolved in order to fulfil the specified nutrient content and the functionality in the final product. Poor rehydration can cause challenges on an industrial level as well as for the consumers. In this thesis, sever
Background: It is well known that a severe cell injury after exposure to ionizing radiation is the induction of DNA double-strand breaks (DSBs). After exposure, an early response to DSBs is the phosphorylation of the histone H2AX molecule regions adjacent to the DSBs, referred to as γ-H2AX foci. The γ-H2AX assay after external exposure is a good tool for investigating the link between the absorbed
Communication between cells located in different parts of an organism is often mediated by membrane-enveloped nanoparticles, such as extracellular vesicles (EVs). EV binding and cell uptake mechanisms depend on the heterogeneous composition of the EV membrane. From a colloidal perspective, the EV membrane interacts with other biological interfaces via both specific and non-specific interactions, w
Processing of the recycling proteoglycan glypican-1 involves the release of its heparan sulfate chains by copper ion- and nitric oxide-catalyzed ascorbate-triggered autodegradation. The Alzheimer disease amyloid precursor protein (APP) and its paralogue, the amyloid precursor-like protein 2 (APLP2), contain copper ion-, zinc ion-, and heparan sulfate-binding domains. We have investigated the possi
Boronate-containing thin polyacrylamide gels (B-Gel), polymer brushes (B-Brush) and chemisorbed organosilane layers (B-COSL) were prepared on the surface of glass slides and studied as substrates for carbohydrate-mediated cell adhesion. B-COSL- and B-Brush-modified glass samples exhibited multiple submicron structures densely and irregularly distributed on the glass surface, as found by scanning e
BACKGROUND: Sabellarids, also known as honeycomb or sandcastle worms, when building their tubes, produce chemical signals (free fatty acids) that are responsible for larval settlement and the formation of three-dimensional aggregations. The larval palps and the dorsal hump (becoming the median organ in adults) are presumed to participate in such a substrate selection during settlement. Notably, th
Antibiotics commonly used against Pseudomonas aeruginosa biofilms are believed to elicit the production of reactive oxygen species (ROS) as part of their bactericidal mechanism. Depending on their concentration, ROS can either induce cell death by damaging proteins, lipids, and DNA or cause mutations that can lead to antibiotic resistance. Hence, antioxidant defenses, including catalase enzymes, a
In the past decades, events occurring at the nano-bio interface (i.e., where engineered nanoparticles (NPs) meet biological interfaces such as biomembranes) have been intensively investigated, to address the cytotoxicity of nanomaterials and boost their clinical translation. In this field, lamellar synthetic model membranes have been instrumental to disentangle non-specific interactions between NP
BACKGROUND: Caries and periodontitis are amongst the most prevalent diseases worldwide, leading to pain and loss of oral function for those affected. Prevention relies heavily on mechanical removal of dental plaque biofilms but for populations where this is not achievable, alternative plaque control methods are required. With concerns over undesirable side-effects and potential bacterial resistanc
Macroporous hydrogels (MHs), cryogels, are a new type of biomaterials for tissue engineering that can be produced from any natural or synthetic polymer that forms a gel. Synthetic MHs are rendered bioactive by surface or bulk modifications with extracellular matrix components. In this study, cell response to the architecture of protein ligands, bovine type-I collagen (CG) and human fibrinogen (Fg)
The ability of thermoresponsive, amine-functionalized microgel particles to take part in microgelmicrogel inter-cross-linking has previously been reported in the literature, in connection to applications such as for example the formation of stimuli-responsive colloidal gels and colloidosomes [1]. This thesis deals with the synthesis of such thermoresponsive, cross-linkable microgels and their subs
